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Tnfrsf25 tumor necrosis factor receptor superfamily, member 25 [ Mus musculus (house mouse) ]

Gene ID: 85030, updated on 21-Apr-2024

Summary

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Official Symbol
Tnfrsf25provided by MGI
Official Full Name
tumor necrosis factor receptor superfamily, member 25provided by MGI
Primary source
MGI:MGI:1934667
See related
Ensembl:ENSMUSG00000024793 AllianceGenome:MGI:1934667
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DR3; TR3; Wsl; DDR3; LARD; APO-3; TRAMP; WSL-1; WSL-LR; Tnfrsf12
Summary
Predicted to be active in plasma membrane. Orthologous to human TNFRSF25 (TNF receptor superfamily member 25). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in mammary gland adult (RPKM 5.7), spleen adult (RPKM 5.0) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 E2; 4 82.89 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (152199985..152204568)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (152115528..152120119)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene nucleolar protein 9 Neighboring gene pleckstrin homology domain containing, family G (with RhoGef domain) member 5 Neighboring gene STARR-seq mESC enhancer starr_12195 Neighboring gene espin Neighboring gene espin-like pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10294 Neighboring gene STARR-positive B cell enhancer ABC_E4735 Neighboring gene predicted gene 13077

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The cytokine receptor DR3 identifies and promotes the activation of thymic NKT17 cells. Luo S, et al. Cell Mol Life Sci, 2023 Feb 27. PMID 36847849, Free PMC Article
  2. Death Receptor 3 Signaling Controls the Balance between Regulatory and Effector Lymphocytes in SAMP1/YitFc Mice with Crohn's Disease-Like Ileitis. Li Z, et al. Front Immunol, 2018. PMID 29545797, Free PMC Article
  3. Death Receptor 3 regulates distinct pathological attributes of acute versus chronic murine allergic lung inflammation. Singh RK, et al. Cell Immunol, 2017 Oct. PMID 28942944, Free PMC Article
  4. Death receptor 3 mediates TNFSF15- and TNFα-induced endothelial cell apoptosis. Xu LX, et al. Int J Biochem Cell Biol, 2014 Oct. PMID 25161149
  5. Tregs expanded in vivo by TNFRSF25 agonists promote cardiac allograft survival. Wolf D, et al. Transplantation, 2012 Sep 27. PMID 22902792

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of a novel role for TL1A/DR3 deficiency in acute respiratory distress syndrome that exacerbates alveolar epithelial disruption.
    Title: Identification of a novel role for TL1A/DR3 deficiency in acute respiratory distress syndrome that exacerbates alveolar epithelial disruption.
  2. The cytokine receptor DR3 identifies and promotes the activation of thymic NKT17 cells.
    Title: The cytokine receptor DR3 identifies and promotes the activation of thymic NKT17 cells.
  3. Host versus cell-dependent effects of beta-arrestin 1 expression in prostate tumorigenesis.
    Title: Host versus cell-dependent effects of β-arrestin 1 expression in prostate tumorigenesis.
  4. Direct signaling of TL1A-DR3 on fibroblasts induces intestinal fibrosis in vivo.
    Title: Direct signaling of TL1A-DR3 on fibroblasts induces intestinal fibrosis in vivo.
  5. The Role of TNFR2 and DR3 in the In Vivo Expansion of Tregs in T Cell Depleting Transplantation Regimens.
    Title: The Role of TNFR2 and DR3 in the In Vivo Expansion of Tregs in T Cell Depleting Transplantation Regimens.
  6. DR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitus.
    Title: DR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitus.
  7. Activation of the DR3-TL1A Axis in Donor Mice Leads to Regulatory T Cell Expansion and Activation With Reduction in Graft-Versus-Host Disease.
    Title: Activation of the DR3-TL1A Axis in Donor Mice Leads to Regulatory T Cell Expansion and Activation With Reduction in Graft-Versus-Host Disease.
  8. In contrast to pre-menopausal females, post-menopausal serum levels of TL1A are not significantly elevated and that DR3 expression is not induced on CD14+ monocytes. Murine ovariectomy (OVX) model of estrogen-deficiency revealed that early post-OVX expression of DR3 on CD4+ T cells is significantly elevated suggesting that DR3 and TL1A could play a potentially indirect role in early post-menopausal bone loss.
    Title: Oestrogen-deficiency induces bone loss by modulating CD14(+) monocyte and CD4(+) T cell DR3 expression and serum TL1A levels.
  9. this study shows that DR3 signaling modulates a multicellular network, encompassing Tregs, T effectors, and innate lymphoid cells, governing disease development and progression in SAMP mice with Crohn's disease-like ileitis
    Title: Death Receptor 3 Signaling Controls the Balance between Regulatory and Effector Lymphocytes in SAMP1/YitFc Mice with Crohn's Disease-Like Ileitis.
  10. in vivo targeting of the TNF superfamily receptor TNFRSF25 using the TL1A-Ig fusion protein, along with IL-2, resulted in transient but massive Treg expansion in donor mice; transplantation of Treg-expanded donor cells facilitated transplant tolerance without GVHD, with complete sparing of graft-versus-malignancy.
    Title: Marked in Vivo Donor Regulatory T Cell Expansion via Interleukin-2 and TL1A-Ig Stimulation Ameliorates Graft-versus-Host Disease but Preserves Graft-versus-Leukemia in Recipients after Hematopoietic Stem Cell Transplantation.
Submit: New GeneRIF Correction See all GeneRIFs (37)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
tumor necrosis factor receptor superfamily member 25
Names
tumor necrosis factor receptor superfamily, member 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291010.2 → NP_001277939.1  tumor necrosis factor receptor superfamily member 25 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001277939.1

    Status: VALIDATED

    Source sequence(s)
    AL772240
    Consensus CDS
    CCDS71527.1
    UniProtKB/TrEMBL
    B1AWN9, Q99MM1
    Related
    ENSMUSP00000025706.4, ENSMUST00000025706.10
    Conserved Domains (2) summary
    cd13420
    Location:37 → 150
    TNFRSF25; tumor necrosis factor receptor superfamily member 25 (TNFRSF25), also known as death receptor 3 (DR3)
    cl14633
    Location:328 → 404
    DD; Death Domain Superfamily of protein-protein interaction domains

  2. NM_033042.5 → NP_149031.2  tumor necrosis factor receptor superfamily member 25 isoform 2 precursor

    See identical proteins and their annotated locations for NP_149031.2

    Status: VALIDATED

    Source sequence(s)
    AL772240
    Consensus CDS
    CCDS38983.1
    UniProtKB/TrEMBL
    Q8VD70, Q99MM1
    Related
    ENSMUSP00000047823.8, ENSMUST00000035275.8
    Conserved Domains (2) summary
    cd13420
    Location:50 → 163
    TNFRSF25; tumor necrosis factor receptor superfamily member 25 (TNFRSF25), also known as death receptor 3 (DR3)
    cl14633
    Location:304 → 380
    DD; Death Domain Superfamily of protein-protein interaction domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    152199985..152204568
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539318.2 → XP_006539381.1  tumor necrosis factor receptor superfamily member 25 isoform X1

    UniProtKB/TrEMBL
    Q99MM1
    Conserved Domains (2) summary
    cd13420
    Location:50 → 163
    TNFRSF25; tumor necrosis factor receptor superfamily member 25 (TNFRSF25), also known as death receptor 3 (DR3)
    cl14633
    Location:341 → 417
    DD; Death Domain Superfamily of protein-protein interaction domains

  2. XM_030253942.1 → XP_030109802.1  tumor necrosis factor receptor superfamily member 25 isoform X4

    Conserved Domains (1) summary
    cl14633
    Location:157 → 233
    DD; Death Domain Superfamily of protein-protein interaction domains

  3. XM_011250362.1 → XP_011248664.1  tumor necrosis factor receptor superfamily member 25 isoform X3

    Conserved Domains (1) summary
    cl14633
    Location:177 → 253
    DD; Death Domain Superfamily of protein-protein interaction domains

  4. XM_006539319.2 → XP_006539382.1  tumor necrosis factor receptor superfamily member 25 isoform X2

    UniProtKB/TrEMBL
    Q99MM1
    Conserved Domains (2) summary
    cd13420
    Location:66 → 157
    TNFRSF25; tumor necrosis factor receptor superfamily member 25 (TNFRSF25), also known as death receptor 3 (DR3)
    cl14633
    Location:335 → 411
    DD; Death Domain Superfamily of protein-protein interaction domains

RNA

  1. XR_004942012.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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