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MIR22HG MIR22 host gene [ Homo sapiens (human) ]

Gene ID: 84981, updated on 2-Apr-2024

Summary

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Official Symbol
MIR22HGprovided by HGNC
Official Full Name
MIR22 host geneprovided by HGNC
Primary source
HGNC:HGNC:28219
See related
Ensembl:ENSG00000186594 AllianceGenome:HGNC:28219
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C17orf91
Summary
Predicted to act upstream of or within response to wounding. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal (RPKM 35.5), bone marrow (RPKM 31.9) and 24 other tissues See more
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Genomic context

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See MIR22HG in Genome Data Viewer
Location:
17p13.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (1711504..1716272, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (1600429..1605201, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (1614798..1619566, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1554397-1554907 Neighboring gene pre-mRNA processing factor 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1593390-1593890 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1593891-1594391 Neighboring gene TLC domain containing 2 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1619651-1620292 Neighboring gene microRNA 22 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1627561-1628061 Neighboring gene WD repeat domain 81 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1638655-1639172 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1639173-1639688 Neighboring gene Sharpr-MPRA regulatory region 4635 Neighboring gene serpin family F member 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1655564-1656124

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. [Pan-cancer analysis of the expression pattern of long non-coding RNA MIR22HG]. Wang H, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2022 Apr 20. PMID 35527483, Free PMC Article
  2. LncRNA MIR22HG promotes osteoarthritis progression via regulating miR-9-3p/ADAMTS5 pathway. Long H, et al. Bioengineered, 2021 Dec. PMID 34187303, Free PMC Article
  3. Emerging impact of the long noncoding RNA MIR22HG on proliferation and apoptosis in multiple human cancers. Zhang L, et al. J Exp Clin Cancer Res, 2020 Dec 3. PMID 33267888, Free PMC Article
  4. MIR22HG regulates miR-486/PTEN axis in bladder cancer to promote cell proliferation. Tang Q, et al. Biosci Rep, 2020 Jun 26. PMID 32500915, Free PMC Article
  5. Long noncoding RNA MIR22HG is down-regulated in prostate cancer. Shen H, et al. Math Biosci Eng, 2019 Dec 17. PMID 32233607

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA MIR22HG/microRNA-9-3p/IGF1 in nonalcoholic steatohepatitis, the ceRNA network increases fibrosis by inhibiting autophagy and promoting pyroptosis.
    Title: LncRNA MIR22HG/microRNA-9-3p/IGF1 in nonalcoholic steatohepatitis, the ceRNA network increases fibrosis by inhibiting autophagy and promoting pyroptosis.
  2. Long non-coding RNA MIR22HG suppresses the chondrogenic differentiation of human adipose-derived stem cells by interacting with CTCF to upregulate CRLF1.
    Title: Long non-coding RNA MIR22HG suppresses the chondrogenic differentiation of human adipose-derived stem cells by interacting with CTCF to upregulate CRLF1.
  3. Long non-coding RNA MIR22HG inhibits the proliferation and migration, and promotes apoptosis by targeting microRNA-9-3p/ SOCS1 axis in small cell lung cancer cells.
    Title: Long non-coding RNA MIR22HG inhibits the proliferation and migration, and promotes apoptosis by targeting microRNA-9-3p/ SOCS1 axis in small cell lung cancer cells.
  4. Long non-coding RNA MIR22HG suppresses cell proliferation and promotes apoptosis in prostate cancer cells by sponging microRNA-9-3p.
    Title: Long non-coding RNA MIR22HG suppresses cell proliferation and promotes apoptosis in prostate cancer cells by sponging microRNA-9-3p.
  5. [Pan-cancer analysis of the expression pattern of long non-coding RNA MIR22HG].
    Title: [Pan-cancer analysis of the expression pattern of long non-coding RNA MIR22HG].
  6. Identification of circulating miR-22-3p and let-7a-5p as novel diagnostic biomarkers for rheumatoid arthritis.
    Title: Identification of circulating miR-22-3p and let-7a-5p as novel diagnostic biomarkers for rheumatoid arthritis.
  7. MIR22HG inhibits breast cancer progression by stabilizing LATS2 tumor suppressor.
    Title: MIR22HG inhibits breast cancer progression by stabilizing LATS2 tumor suppressor.
  8. LncRNA MIR22HG promotes osteoarthritis progression via regulating miR-9-3p/ADAMTS5 pathway.
    Title: LncRNA MIR22HG promotes osteoarthritis progression via regulating miR-9-3p/ADAMTS5 pathway.
  9. Overexpression of Long Non-Coding RNA MIR22HG Represses Proliferation and Enhances Apoptosis via miR-629-5p/TET3 Axis in Osteosarcoma Cells.
    Title: Overexpression of Long Non-Coding RNA MIR22HG Represses Proliferation and Enhances Apoptosis via miR-629-5p/TET3 Axis in Osteosarcoma Cells.
  10. Long noncoding RNA MIR22HG is down-regulated in prostate cancer.
    Title: Long noncoding RNA MIR22HG is down-regulated in prostate cancer.
Submit: New GeneRIF Correction See all GeneRIFs (25)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels.
EBI GWAS Catalog
Discovery and fine mapping of serum protein loci through transethnic meta-analysis.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • MIR22 host gene (non-protein coding)

Clone Names

  • MGC14376, MGC149751, DKFZp686O06159

Gene Ontology Provided by GOA

Component Evidence Code Pubs
part_of RISC complex IEA
Inferred from Electronic Annotation
more info
  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_028502.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC130343
    Related
    ENST00000574306.2

  2. NR_028503.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC130343
    Related
    ENST00000575626.6

  3. NR_028504.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC130343
    Related
    ENST00000334146.9

  4. NR_028505.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC130343
    Related
    ENST00000690262.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    1711504..1716272 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187611.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    141532..146300 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    1600429..1605201 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001001870.1: Suppressed sequence

    Description
    NM_001001870.1: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.

  2. NM_032895.2: Suppressed sequence

    Description
    NM_032895.2: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0VDD5.1 GenPept UniProtKB/Swiss-Prot:Q0VDD5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Miscellaneous