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CROCCP2 CROCC pseudogene 2 [ Homo sapiens (human) ]

Gene ID: 84809, updated on 10-Oct-2023

Summary

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Official Symbol
CROCCP2provided by HGNC
Official Full Name
CROCC pseudogene 2provided by HGNC
Primary source
HGNC:HGNC:28170
See related
AllianceGenome:HGNC:28170
Gene type
pseudo
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CROCCL1
Summary
Predicted to be involved in centrosome cycle. Predicted to be located in ciliary rootlet. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen (RPKM 16.1), duodenum (RPKM 15.2) and 25 other tissues See more
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Genomic context

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Location:
1p36.13
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (16632279..16646683, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (16585910..16598560)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (16944751..16957401, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:16890771-16891648 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:16892527-16893404 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr1:16893405-16894282 Neighboring gene NBPF member 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:16902769-16903269 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:16916551-16917050 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:16918378-16918567 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:16929815-16930315 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:16933765-16934266 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:16934267-16934766 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:16939903-16940860 Neighboring gene rootletin-like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:16945048-16945716 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:16945717-16946384 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:16946385-16947053 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:16950326-16950836 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 334 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:16963058-16963558 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:16964533-16965424 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr1:16970879-16971669 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:16971670-16972459 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:16973171-16973790 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:16974411-16975030 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:16975031-16975648 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:16976311-16976811 Neighboring gene macrophage stimulating 1 pseudogene 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:16983417-16984225 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:16992232-16993198 Neighboring gene FAM231A/C-like protein LOC102723383 Neighboring gene RNA, U1 small nuclear 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. CROCCP2 acts as a human-specific modifier of cilia dynamics and mTOR signaling to promote expansion of cortical progenitors. Van Heurck R, et al. Neuron, 2023 Jan 4. PMID 36334595, Free PMC Article
  2. Lineage-specific gene duplication and loss in human and great ape evolution. Fortna A, et al. PLoS Biol, 2004 Jul. PMID 15252450, Free PMC Article
  3. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article
  4. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CROCCP2 acts as a human-specific modifier of cilia dynamics and mTOR signaling to promote expansion of cortical progenitors.
    Title: CROCCP2 acts as a human-specific modifier of cilia dynamics and mTOR signaling to promote expansion of cortical progenitors.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • ciliary rootlet coiled-coil, rootletin pseudogene 2
  • ciliary rootlet coiled-coil, rootletin-like 1

Clone Names

  • MGC12760

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_026752.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA584096, BC006312, BC010508, BC047736

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    16632279..16646683 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_008485581.1 RNA Sequence

  2. XR_008485578.1 RNA Sequence

  3. XR_008485577.1 RNA Sequence

  4. XR_008485576.1 RNA Sequence

  5. XR_008485579.1 RNA Sequence

  6. XR_008485580.1 RNA Sequence

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791756.1 Reference GRCh38.p14 PATCHES

    Range
    993816..1006467
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    16585910..16598560
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_032723.2: Suppressed sequence

    Description
    NM_032723.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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