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Cox4i2 cytochrome c oxidase subunit 4I2 [ Mus musculus (house mouse) ]

Gene ID: 84682, updated on 5-Mar-2024

Summary

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Official Symbol
Cox4i2provided by MGI
Official Full Name
cytochrome c oxidase subunit 4I2provided by MGI
Primary source
MGI:MGI:2135755
See related
Ensembl:ENSMUSG00000009876 AllianceGenome:MGI:2135755
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cox4b; CoxIV-2
Summary
Predicted to enable cytochrome-c oxidase activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Located in mitochondrial membrane. Is expressed in several structures, including alimentary system; cardiovascular system; hindlimb musculature; nervous system; and sensory organ. Orthologous to human COX4I2 (cytochrome c oxidase subunit 4I2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 10.6), limb E14.5 (RPKM 2.1) and 8 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 H1; 2 75.41 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (152596093..152606957)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (152753916..152765039)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene inhibitor of DNA binding 1, HLH protein Neighboring gene high mobility group box 1-like pseudogene Neighboring gene predicted gene, 32057 Neighboring gene STARR-seq mESC enhancer starr_06077 Neighboring gene BCL2-like 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:152614671-152614780 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:152615325-152615529 Neighboring gene STARR-seq mESC enhancer starr_06078 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:152620177-152620625 Neighboring gene STARR-seq mESC enhancer starr_06080 Neighboring gene predicted gene, 32211 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:152642094-152642203 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:152642211-152642412 Neighboring gene STARR-seq mESC enhancer starr_06082 Neighboring gene STARR-positive B cell enhancer mm9_chr2:152651505-152651806 Neighboring gene STARR-positive B cell enhancer mm9_chr2:152656963-152657264 Neighboring gene STARR-positive B cell enhancer ABC_E514 Neighboring gene TPX2, microtubule-associated Neighboring gene microRNA 5622

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mitochondrial Complex IV Subunit 4 Isoform 2 Is Essential for Acute Pulmonary Oxygen Sensing. Sommer N, et al. Circ Res, 2017 Aug 4. PMID 28620066, Free PMC Article
  2. Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology. Hüttemann M, et al. FASEB J, 2012 Sep. PMID 22730437, Free PMC Article
  3. Cytochrome c oxidase subunit IV is essential for assembly and respiratory function of the enzyme complex. Li Y, et al. J Bioenerg Biomembr, 2006 Dec. PMID 17091399, Free PMC Article
  4. Effect of hypoxia on the transcription pattern of subunit isoforms and the kinetics of cytochrome c oxidase in cortical astrocytes and cerebellar neurons. Horvat S, et al. J Neurochem, 2006 Nov. PMID 16981895
  5. Cox4i2, Ifit2, and Prdm11 Mutant Mice: Effective Selection of Genes Predisposing to an Altered Airway Inflammatory Response from a Large Compendium of Mutant Mouse Lines. Horsch M, et al. PLoS One, 2015. PMID 26263558, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Acute O2 sensing through HIF2alpha-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors.
    Title: Acute O(2) sensing through HIF2α-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors.
  2. Cox4i2 is essential for acute but not chronic pulmonary oxygen sensing by triggering mitochondrial hyperpolarization.
    Title: Mitochondrial Complex IV Subunit 4 Isoform 2 Is Essential for Acute Pulmonary Oxygen Sensing.
  3. Data (including data from cells of transgenic mouse embryos) suggest Hif1a (hypoxia inducible factor 1 alpha subunit) up-regulates transcription of heart/muscle isoform Cox7a1 under hypoxia; hypoxic induction of isoform Cox4i2 is HIF1a-independent.
    Title: Hypoxia Inducible Factors Modulate Mitochondrial Oxygen Consumption and Transcriptional Regulation of Nuclear-Encoded Electron Transport Chain Genes.
  4. propose a model in which reduced tissue ATP levels explain protection from airway hyperresponsiveness, i.e., absence of COX4i2 leads to reduced lung COX activity and ATP levels, which results in impaired airway constriction
    Title: Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology.
  5. the presence of the COX isoform IV-2 suppresses the sensitivity of COX to its allosteric regulator ATP and overrules the regulation of COX by the cellular energy level
    Title: Effect of hypoxia on the transcription pattern of subunit isoforms and the kinetics of cytochrome c oxidase in cortical astrocytes and cerebellar neurons.
  6. Under conditions of reduced oxygen availability, hypoxia-inducible factor 1 reciprocally regulates COX4 subunit expression by activating transcription of the genes encoding COX4-2 and LON, a mitochondrial protease that is required for COX4-1 degradation.
    Title: HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells.
  7. Cytochrome c oxidase subunit IV is essential for assembly and respiratory function of the enzyme complex.
    Title: Cytochrome c oxidase subunit IV is essential for assembly and respiratory function of the enzyme complex.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytochrome-c oxidase activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables cytochrome-c oxidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial electron transport, cytochrome c to oxygen ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mitochondrial respiratory chain complex IV IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial respiratory chain complex IV ISA
Inferred from Sequence Alignment
more info
 PubMed 
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
cytochrome c oxidase subunit 4 isoform 2, mitochondrial
Names
cytochrome c oxidase, subunit IVb
NP_444321.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053091.2 → NP_444321.1  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform 2 precursor

    See identical proteins and their annotated locations for NP_444321.1

    Status: VALIDATED

    Source sequence(s)
    AL731857
    Consensus CDS
    CCDS16898.1
    UniProtKB/Swiss-Prot
    Q91W29
    Related
    ENSMUSP00000010020.6, ENSMUST00000010020.12
    Conserved Domains (1) summary
    pfam02936
    Location:38 → 171
    COX4; Cytochrome c oxidase subunit IV

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    152596093..152606957
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91W29.1 GenPept UniProtKB/Swiss-Prot:Q91W29

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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