U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TNRC18 trinucleotide repeat containing 18 [ Homo sapiens (human) ]

Gene ID: 84629, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
TNRC18provided by HGNC
Official Full Name
trinucleotide repeat containing 18provided by HGNC
Primary source
HGNC:HGNC:11962
See related
Ensembl:ENSG00000182095 AllianceGenome:HGNC:11962
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAGL79; TNRC18A
Summary
Predicted to enable chromatin binding activity. Located in cytosol; mitochondrion; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney (RPKM 6.4), colon (RPKM 6.2) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See TNRC18 in Genome Data Viewer
Location:
7p22.1
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (5306811..5423834, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (5424509..5541506, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (5346442..5463465, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene MPRA-validated peak6354 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17908 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17909 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17910 Neighboring gene RNA, U6 small nuclear 215, pseudogene Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:5257932-5259131 Neighboring gene WD repeat domain, phosphoinositide interacting 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5262434-5263183 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25574 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17911 Neighboring gene Sharpr-MPRA regulatory region 13937 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25575 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17912 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5323448-5324013 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5324014-5324580 Neighboring gene Sharpr-MPRA regulatory region 9837 Neighboring gene Sharpr-MPRA regulatory region 3727 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17913 Neighboring gene solute carrier family 29 member 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5350589-5351090 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5351091-5351590 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5362189-5362722 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5362723-5363256 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5387551-5388392 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5390077-5390917 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5395754-5396256 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5421456-5422020 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5422021-5422584 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25576 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5441055-5441556 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5443987-5444488 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5447921-5448510 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5447331-5447920 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5458249-5458998 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17914 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5467243-5467992 Neighboring gene long intergenic non-protein coding RNA 2983 Neighboring gene long intergenic non-protein coding RNA 3073 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5485342-5486174 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5491262-5491967 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5495336-5495836 Neighboring gene F-box and leucine rich repeat protein 18 Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Disruption of PCDH10 and TNRC18 Genes due to a Balanced Translocation. Zamariolli M, et al. Cytogenet Genome Res, 2020. PMID 32535594
  2. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. Denis NJ, et al. Proteomics, 2007 Mar. PMID 17370265
  3. cDNAs with long CAG trinucleotide repeats from human brain. Margolis RL, et al. Hum Genet, 1997 Jul. PMID 9225980
  4. Common variants in left/right asymmetry genes and pathways are associated with relative hand skill. Brandler WM, et al. PLoS Genet, 2013. PMID 24068947, Free PMC Article
  5. Family with sequence similarity 60A (FAM60A) protein is a cell cycle-fluctuating regulator of the SIN3-HDAC1 histone deacetylase complex. Muñoz IM, et al. J Biol Chem, 2012 Sep 21. PMID 22865885, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Disruption of PCDH10 and TNRC18 Genes due to a Balanced Translocation.
    Title: Disruption of PCDH10 and TNRC18 Genes due to a Balanced Translocation.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common variants in left/right asymmetry genes and pathways are associated with relative hand skill.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • KIAA1856

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
  
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

Go to the top of the page Help
Preferred Names
trinucleotide repeat-containing gene 18 protein
Names
long CAG trinucleotide repeat-containing gene 79 protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034123.1 RefSeqGene

    Range
    4713..121736
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001080495.3 → NP_001073964.2  trinucleotide repeat-containing gene 18 protein

    See identical proteins and their annotated locations for NP_001073964.2

    Status: VALIDATED

    Source sequence(s)
    AB058759, AC092171, AC093376, AC093620, AI738451, BC029940, BC131808, BX396597, CN295035, CR993399, DN990416, DR159642, U80753
    Consensus CDS
    CCDS47534.1
    UniProtKB/Swiss-Prot
    A8MX41, O15417, Q96JH1, Q96K91
    UniProtKB/TrEMBL
    H9KVB4
    Related
    ENSP00000395538.1, ENST00000430969.6
    Conserved Domains (3) summary
    PHA03247
    Location:2291 → 2531
    PHA03247; large tegument protein UL36; Provisional
    cd04714
    Location:2816 → 2960
    BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
    cd20469
    Location:2220 → 2286
    Tudor_TNRC18; Tudor domain found in trinucleotide repeat-containing gene 18 protein (TNRC18) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    5306811..5423834 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012737.3 → XP_016868226.1  trinucleotide repeat-containing gene 18 protein isoform X9

    UniProtKB/TrEMBL
    H9KVB4

  2. XM_047420983.1 → XP_047276939.1  trinucleotide repeat-containing gene 18 protein isoform X9

  3. XM_017012728.3 → XP_016868217.1  trinucleotide repeat-containing gene 18 protein isoform X1

    UniProtKB/TrEMBL
    H9KVB4

  4. XM_047420978.1 → XP_047276934.1  trinucleotide repeat-containing gene 18 protein isoform X1

  5. XM_047420977.1 → XP_047276933.1  trinucleotide repeat-containing gene 18 protein isoform X1

  6. XM_017012736.2 → XP_016868225.1  trinucleotide repeat-containing gene 18 protein isoform X9

    UniProtKB/TrEMBL
    H9KVB4

  7. XM_047420976.1 → XP_047276932.1  trinucleotide repeat-containing gene 18 protein isoform X1

  8. XM_017012732.2 → XP_016868221.1  trinucleotide repeat-containing gene 18 protein isoform X6

    UniProtKB/TrEMBL
    H9KVB4

  9. XM_047420980.1 → XP_047276936.1  trinucleotide repeat-containing gene 18 protein isoform X4

  10. XM_017012730.2 → XP_016868219.1  trinucleotide repeat-containing gene 18 protein isoform X2

    UniProtKB/TrEMBL
    H9KVB4

  11. XM_047420981.1 → XP_047276937.1  trinucleotide repeat-containing gene 18 protein isoform X8

  12. XM_017012731.2 → XP_016868220.1  trinucleotide repeat-containing gene 18 protein isoform X5

    UniProtKB/TrEMBL
    H9KVB4

  13. XM_047420979.1 → XP_047276935.1  trinucleotide repeat-containing gene 18 protein isoform X3

    UniProtKB/Swiss-Prot
    A8MX41, O15417, Q96JH1, Q96K91
    Conserved Domains (3) summary
    PHA03247
    Location:2291 → 2531
    PHA03247; large tegument protein UL36; Provisional
    cd04714
    Location:2816 → 2960
    BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
    cd20469
    Location:2220 → 2286
    Tudor_TNRC18; Tudor domain found in trinucleotide repeat-containing gene 18 protein (TNRC18) and similar proteins

  14. XM_017012734.3 → XP_016868223.1  trinucleotide repeat-containing gene 18 protein isoform X7

    UniProtKB/TrEMBL
    H9KVB4

  15. XM_017012739.3 → XP_016868228.1  trinucleotide repeat-containing gene 18 protein isoform X10

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    5424509..5541506 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054359257.1 → XP_054215232.1  trinucleotide repeat-containing gene 18 protein isoform X9

  2. XM_054359258.1 → XP_054215233.1  trinucleotide repeat-containing gene 18 protein isoform X9

  3. XM_054359248.1 → XP_054215223.1  trinucleotide repeat-containing gene 18 protein isoform X1

  4. XM_054359253.1 → XP_054215228.1  trinucleotide repeat-containing gene 18 protein isoform X6

  5. XM_054359252.1 → XP_054215227.1  trinucleotide repeat-containing gene 18 protein isoform X5

  6. XM_054359255.1 → XP_054215230.1  trinucleotide repeat-containing gene 18 protein isoform X8

  7. XM_054359250.1 → XP_054215225.1  trinucleotide repeat-containing gene 18 protein isoform X2

  8. XM_054359251.1 → XP_054215226.1  trinucleotide repeat-containing gene 18 protein isoform X4

  9. XM_054359249.1 → XP_054215224.1  trinucleotide repeat-containing gene 18 protein isoform X1

  10. XM_054359256.1 → XP_054215231.1  trinucleotide repeat-containing gene 18 protein isoform X9

  11. XM_054359254.1 → XP_054215229.1  trinucleotide repeat-containing gene 18 protein isoform X7

  12. XM_054359259.1 → XP_054215234.1  trinucleotide repeat-containing gene 18 protein isoform X10

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001013722.1: Suppressed sequence

    Description
    NM_001013722.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15417.3 GenPept UniProtKB/Swiss-Prot:O15417

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous