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QRFPR pyroglutamylated RFamide peptide receptor [ Homo sapiens (human) ]

Gene ID: 84109, updated on 11-Apr-2024

Summary

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Official Symbol
QRFPRprovided by HGNC
Official Full Name
pyroglutamylated RFamide peptide receptorprovided by HGNC
Primary source
HGNC:HGNC:15565
See related
Ensembl:ENSG00000186867 MIM:606925; AllianceGenome:HGNC:15565
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AQ27; GPR103; SP9155
Summary
Enables G protein-coupled receptor activity. Involved in G protein-coupled receptor signaling pathway. Predicted to be located in non-motile cilium. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
all
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Genomic context

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See QRFPR in Genome Data Viewer
Location:
4q27
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (121328642..121381018, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (124632974..124685273, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (122249797..122302173, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene neuron derived neurotrophic factor Neighboring gene NDNF antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 6302 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21863 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21864 Neighboring gene TNFAIP3 interacting protein 3 Neighboring gene RNA, U6 small nuclear 948, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:122159169-122159668 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21865 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:122301959-122302743 Neighboring gene KIAA1191 pseudogene 1 Neighboring gene uncharacterized LOC107986309 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:122332093-122332620 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:122339441-122339942 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:122339943-122340442 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15658 Neighboring gene TUBB4B pseudogene 5 Neighboring gene uncharacterized LOC107986310

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The variations in human orphan G protein-coupled receptor QRFPR affect PI3K-AKT-mTOR signaling. Li H, et al. J Clin Lab Anal, 2021 Jul. PMID 34018631, Free PMC Article
  2. Two naturally occurring mutations of human GPR103 define distinct G protein selection bias. Ma Q, et al. Biochim Biophys Acta Mol Cell Res, 2021 Jun. PMID 33872671
  3. N-glycosylation of the human neuropeptide QRFP receptor (QRFPR) is essential for ligand binding and receptor activation. Wang W, et al. J Neurochem, 2021 Jul. PMID 33655503
  4. Whole-exome sequencing in multiplex preeclampsia families identifies novel candidate susceptibility genes. Melton PE, et al. J Hypertens, 2019 May. PMID 30633125
  5. Involvement of the glutamine RF‑amide peptide and its cognate receptor GPR103 in prostate cancer. Kawan MA, et al. Oncol Rep, 2019 Feb. PMID 30483810, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The variations in human orphan G protein-coupled receptor QRFPR affect PI3K-AKT-mTOR signaling.
    Title: The variations in human orphan G protein-coupled receptor QRFPR affect PI3K-AKT-mTOR signaling.
  2. N-glycosylation of the human neuropeptide QRFP receptor (QRFPR) is essential for ligand binding and receptor activation.
    Title: N-glycosylation of the human neuropeptide QRFP receptor (QRFPR) is essential for ligand binding and receptor activation.
  3. Two naturally occurring mutations of human GPR103 define distinct G protein selection bias.
    Title: Two naturally occurring mutations of human GPR103 define distinct G protein selection bias.
  4. The expression of both QRFP and GPR103 at the gene and protein level was higher in human prostate cancer tissue samples compared to control and benign prostatic hyperplasia samples.
    Title: Involvement of the glutamine RF‑amide peptide and its cognate receptor GPR103 in prostate cancer.
  5. The study represents the first to use WES in multiplex families for preeclampsia and identifies two novel genes (QRFPR and C1orf35) not previously associated with preeclampsia and find nominal association of rs34270076 with protein levels.
    Title: Whole-exome sequencing in multiplex preeclampsia families identifies novel candidate susceptibility genes.
  6. Effects of systematic N-terminus deletions and benzoylations of endogenous RF-amide peptides on NPFF1R, NPFF2R, GPR10, GPR54 and GPR103.
    Title: Effects of systematic N-terminus deletions and benzoylations of endogenous RF-amide peptides on NPFF1R, NPFF2R, GPR10, GPR54 and GPR103.
  7. Results suggest that GPR103b and QRFP work in an autocrine/paracrine manner to regulate adipogenesis.
    Title: GPR103b functions in the peripheral regulation of adipogenesis.
  8. characterization and tissue distribution of SP9155 (GPR103) ligand
    Title: Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155.
  9. QRFP and GPR103A/B may regulate diverse neuroendocrine and behavioral functions and implicate this neuropeptide system in metabolic syndrome
    Title: A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC149217

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables neuropeptide Y receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IC
Inferred by Curator
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
pyroglutamylated RF-amide peptide receptor
Names
G-protein coupled receptor 103
QRFP receptor
orexigenic neuropeptide QRFP receptor
peptide P518 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198179.3 → NP_937822.2  pyroglutamylated RF-amide peptide receptor

    See identical proteins and their annotated locations for NP_937822.2

    Status: VALIDATED

    Source sequence(s)
    AB109629, AC093867, BG169612, DA461055
    Consensus CDS
    CCDS3719.1
    UniProtKB/Swiss-Prot
    Q96P65
    UniProtKB/TrEMBL
    G4XH69
    Related
    ENSP00000377948.2, ENST00000394427.3
    Conserved Domains (1) summary
    pfam00001
    Location:62 → 332
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    121328642..121381018 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008693.3 → XP_016864182.1  pyroglutamylated RF-amide peptide receptor isoform X1

    UniProtKB/TrEMBL
    F2Z3L3
    Related
    ENSP00000423369.1, ENST00000507331.5
    Conserved Domains (2) summary
    cd14964
    Location:48 → 72
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:46 → 187
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    124632974..124685273 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350983.1 → XP_054206958.1  pyroglutamylated RF-amide peptide receptor isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96P65.2 GenPept UniProtKB/Swiss-Prot:Q96P65

Gene LinkOut

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