Kremen1 kringle containing transmembrane protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kremen1provided by MGI
Official Full Name: kringle containing transmembrane protein 1provided by MGI
Primary source: MGI:MGI:1933988
See related: Ensembl:ENSMUSG00000020393 AllianceGenome:MGI:1933988
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Krm1; Kremen
Summary: Involved in several processes, including negative regulation of axon regeneration; negative regulation of canonical Wnt signaling pathway; and negative regulation of ossification. Located in neuronal cell body. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb ectoderm; and sensory organ. Human ortholog(s) of this gene implicated in ectodermal dysplasia 13. Orthologous to human KREMEN1 (kringle containing transmembrane protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in thymus adult (RPKM 53.1), heart adult (RPKM 22.2) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A1; 11 3.36 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (5141551..5212220, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (5191551..5261713, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kremen1 is expressed in prosensory cells during cochlear developme
Title: Kremen1 regulates mechanosensory hair cell development in the mammalian cochlea and the zebrafish lateral line.
Dickkopf1 receptor Kremen1 is a bona fide dependence receptor, triggering cell death unless bound to its ligand.
Title: Kremen1 and Dickkopf1 control cell survival in a Wnt-independent manner.
Kremen1 has a pro-apoptotic activity that is decreased upon Dkk1 binding
Title: Kremen1 and Dickkopf1 control cell survival in a Wnt-independent manner.
Dkk1 and Kremen1 play roles in blastocyst activation and uterine receptivity during the window of implantation.
Title: Roles of Dickkopf-1 and its receptor Kremen1 during embryonic implantation in mice.
Kremen may not be essential for Dkk1-mediated Wnt antagonism and Kremen may only play a role when cells express a high level of LRP5/6
Title: Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism.
This study provides the first genetic evidence for a functional interaction of Kremen proteins with Dkk1 as negative regulators of Wnt/beta-catenin signaling.
Title: Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density.
Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling
Title: Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

Ins1 (e-PCR), detects polymorphism
- UniSTS:507948

Kremen1 (e-PCR), detects polymorphism
- UniSTS:507012

AV002070 (e-PCR)
- UniSTS:180145

NoName (e-PCR)
- UniSTS:236506

Kremen1 (e-PCR), detects polymorphism
- UniSTS:496614

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in limb development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of ossification	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: kremen protein 1

Names: dickkopf receptor; kringle domain-containing transmembrane protein 1; kringle-coding gene marking the eye and the nose; kringle-containing protein marking the eye and the nose

NP_115772.2

EC 2.3.2.27

XP_006514975.1

EC 2.3.2.27

XP_006514976.1

EC 2.3.2.27

XP_036013001.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032396.3 → NP_115772.2 kremen protein 1 precursor

See identical proteins and their annotated locations for NP_115772.2

Status: VALIDATED

Source sequence(s)

BC049771, BC082546

Consensus CDS

CCDS24399.1

UniProtKB/Swiss-Prot

Q640Q6, Q99N43

Related

ENSMUSP00000020662.9, ENSMUST00000020662.15

Conserved Domains (3) summary

cd00041
Location:214 → 320

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00108
Location:31 → 114

KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

pfam01822
Location:119 → 200

WSC; WSC domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

5141551..5212220 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036157108.1 → XP_036013001.1 kremen protein 1 isoform X2

Conserved Domains (2) summary

cd00041
Location:99 → 205

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

pfam01822
Location:5 → 85

WSC; WSC domain
XM_006514912.4 → XP_006514975.1 kremen protein 1 isoform X1

Conserved Domains (3) summary

cd00041
Location:214 → 320

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00108
Location:31 → 114

KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

pfam01822
Location:119 → 200

WSC; WSC domain
XM_006514913.4 → XP_006514976.1 kremen protein 1 isoform X3

Conserved Domains (2) summary

cd00108
Location:31 → 114

KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

pfam01822
Location:119 → 200

WSC; WSC domain