ABCC1 multidrug resistance-associated protein 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: ABCC1
Gene description: multidrug resistance-associated protein 1
Primary source: Araport:AT1G30400
Locus tag: AT1G30400
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: Arabidopsis thaliana ATP-binding cassette C1; ARABIDOPSIS THALIANA MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1; ATABCC1; ATMRP1; ATP-binding cassette C1; EST1; GLUTATHIONE S-CONJUGATE TRANSPORTING ATPASE; MRP1; multidrug resistance-associated protein 1; T4K22.12; T4K22_12
Summary: glutathione S-conjugate transporting ATPase (AtMRP1) mRNA. An ABCC-type arsenite-phytochelatin transporter. The expression of this gene is upregulated by herbicide safeners such as benoxacor and fenclorim.
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Genomic context

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Location:: chromosome: 1

Exon count:: 28

Sequence:: Chromosome: 1; NC_003070.9 (10727317..10738092)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transport of acylated anthocyanins by the Arabidopsis ATP-binding cassette transporters AtABCC1, AtABCC2, and AtABCC14.
Title: Transport of acylated anthocyanins by the Arabidopsis ATP-binding cassette transporters AtABCC1, AtABCC2, and AtABCC14.
Data indicate that phosphorylation of serine Ser846 is required for the arsenic (As) resistance function of ATP-Binding Cassette (ABC) transporter ABCC1 (AtABCC1).
Title: Identification of amino acid residues important for the arsenic resistance function of Arabidopsis ABCC1.
MRP1 is important for vacuolar accumulation of antifolates as well as tolerance against arsenic, both of which involved phosphorylation in the serine triads at the C terminal nucleotide binding domain of MRP1.
Title: Arabidopsis thaliana MRP1 (AtABCC1) nucleotide binding domain contributes to arsenic stress tolerance with serine triad phosphorylation.
AtABCC1 and AtABCC2 are important vacuolar transporters that confer tolerance to cadmium and mercury, in addition to their role in arsenic detoxification.
Title: The phytochelatin transporters AtABCC1 and AtABCC2 mediate tolerance to cadmium and mercury.
Data show that the ABC transporters AtABCC1 (At1g30400) and AtABCC2 (AT2G34660) exhibit abscisic acid glucosyl ester (ABA-GE) transport activity in vitro.
Title: Vacuolar transport of abscisic acid glucosyl ester is mediated by ATP-binding cassette and proton-antiport mechanisms in Arabidopsis.
AtABCC1 and AtABCC2 are the long-sought and major vacuolar phytochelatin transporters
Title: Arsenic tolerance in Arabidopsis is mediated by two ABCC-type phytochelatin transporters.
atmrp1 knock-out mutants are more sensitive than wild-type plants to growth retardation by nanomolar concentrations of MTX, and this is associated with impaired vacuolar antifolate sequestration.
Title: Plant Vacuolar ATP-binding Cassette Transporters That Translocate Folates and Antifolates in Vitro and Contribute to Antifolate Tolerance in Vivo.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001036039.2

Supported by ESTs:

NM_102777.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables (+)-abscisic acid D-glucopyranosyl ester transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables ABC-type phytochelatin transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables ABC-type transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables ABC-type xenobiotic transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type xenobiotic transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled arsenite transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables ATPase-coupled transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within (+)-abscisic acid D-glucopyranosyl ester transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within arsenite transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to arsenic-containing substance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within xenobiotic transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within xenobiotic transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info
located_in plant-type vacuole	HDA more info	PubMed
located_in plasmodesma	HDA more info	PubMed
located_in vacuolar membrane	HDA more info	PubMed
located_in vacuole	HDA more info	PubMed

General protein information

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Preferred Names: multidrug resistance-associated protein 1

NP_001031116.1

ARABIDOPSIS THALIANA MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1 (ATMRP1); FUNCTIONS IN: xenobiotic-transporting ATPase activity, ATPase activity, coupled to transmembrane movement of substances; INVOLVED IN: response to cyclopentenone; LOCATED IN: vacuolar membrane, plasma membrane, vacuole, plant-type vacuole; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), ABC transporter-like (InterPro:IPR003439), ABC transporter, transmembrane domain, type 1 (InterPro:IPR011527), ABC transporter integral membrane type 1 (InterPro:IPR017940), ABC transporter, transmembrane domain (InterPro:IPR001140), ABC transporter, conserved site (InterPro:IPR017871); BEST Arabidopsis thaliana protein match is: multidrug resistance-associated protein 2 (TAIR:AT2G34660.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NP_174329.1

multidrug resistance-associated protein 1 (MRP1); FUNCTIONS IN: xenobiotic-transporting ATPase activity, ATPase activity, coupled to transmembrane movement of substances; INVOLVED IN: response to cyclopentenone; LOCATED IN: vacuolar membrane, plasma membrane, vacuole, plant-type vacuole; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), ABC transporter-like (InterPro:IPR003439), ABC transporter, transmembrane domain, type 1 (InterPro:IPR011527), ABC transporter integral membrane type 1 (InterPro:IPR017940), ABC transporter, transmembrane domain (InterPro:IPR001140), ABC transporter, conserved site (InterPro:IPR017871); BEST Arabidopsis thaliana protein match is: multidrug resistance-associated protein 2 (TAIR:AT2G34660.2); Has 677063 Blast hits to 355607 proteins in 3971 species: Archae - 12123; Bacteria - 549360; Metazoa - 12555; Fungi - 7909; Plants - 6149; Viruses - 21; Other Eukaryotes - 88946 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

10727317..10738092

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_102777.3 → NP_174329.1 multidrug resistance-associated protein 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_174329.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O24635, Q8RX76, Q9C8G9, Q9SAQ1

UniProtKB/TrEMBL

A0A178WBV0, A0A5S9WDU0, A0A7G2DWV7

Conserved Domains (1) summary

PLN03130
Location:1 → 1622

PLN03130; ABC transporter C family member; Provisional
NM_001036039.2 → NP_001031116.1 multidrug resistance-associated protein 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001031116.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O24635, Q8RX76, Q9C8G9, Q9SAQ1

UniProtKB/TrEMBL

A0A178WBV0, A0A5S9WDU0, A0A7G2DWV7

Conserved Domains (1) summary

PLN03130
Location:1 → 1622

PLN03130; ABC transporter C family member; Provisional