ATG3 autophagy 3 (APG3) [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: ATG3
Gene description: autophagy 3 (APG3)
Primary source: Araport:AT5G61500
Locus tag: AT5G61500
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATATG3; K11J9.1; K11J9_1
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Genomic context

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Location:: chromosome: 5

Exon count:: 10

Sequence:: Chromosome: 5; NC_003076.8 (24733785..24736876, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

After screening mutagenized lon2-2 seedlings for restored indole-3-butyric acid responsiveness, stabilization and processing of peroxisomal proteins, levels of several ATG proteins, and levels of the selective autophagy receptor NBR1/At4g24690, which accumulates when autophagy is impaired, were evaluated. The study recovered 21 alleles disrupting 6 ATG genes: ATG2, ATG3, ATG5, ATG7, ATG16, and ATG18a.
Title: A facile forward-genetic screen for Arabidopsis autophagy mutants reveals twenty-one loss-of-function mutations disrupting six ATG genes.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001345476.1

Supported by ESTs:

NM_125543.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables Atg8-family ligase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: autophagy 3 (APG3)

NP_568934.1

ATG3; CONTAINS InterPro DOMAIN/s: Autophagy-related protein 3 (InterPro:IPR007135), Autophagy-related protein 3, C-terminal (InterPro:IPR019461), Autophagy-related protein 3, N-terminal (InterPro:IPR007134); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

24733785..24736876 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_125543.5 → NP_568934.1 autophagy 3 (APG3) [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_568934.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0WWQ1, Q8L982, Q8S930, Q9FKG9

UniProtKB/TrEMBL

A0A178UM04, A0A5S9YG16, A0A654GD50

Conserved Domains (2) summary

pfam03986
Location:7 → 138

Autophagy_N; Autophagocytosis associated protein (Atg3), N-terminal domain

pfam03987
Location:37 → 302

Autophagy_act_C; Autophagocytosis associated protein, active-site domain
NM_001345476.1 → NP_001331033.1 autophagy 3 (APG3) [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8BCL3