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Naaladl1 N-acetylated alpha-linked acidic dipeptidase-like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 83568, updated on 13-Apr-2024

Summary

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Official Symbol
Naaladl1provided by RGD
Official Full Name
N-acetylated alpha-linked acidic dipeptidase-like 1provided by RGD
Primary source
RGD:620987
See related
Ensembl:ENSRNOG00000021000 AllianceGenome:RGD:620987
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
I100; Naaladasel
Summary
Predicted to enable exopeptidase activity; metal ion binding activity; and protein homodimerization activity. Predicted to be involved in peptide catabolic process. Located in apical plasma membrane. Is integral component of membrane. Orthologous to human NAALADL1 (N-acetylated alpha-linked acidic dipeptidase like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 13.5), Adrenal (RPKM 10.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q43
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (212829917..212843474)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (203400632..203414195)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (221470675..221484222)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 262 Neighboring gene zinc finger protein-like 1 Neighboring gene cell division cycle associated 5 Neighboring gene uncharacterized LOC120097396 Neighboring gene SAC3 domain containing 1 Neighboring gene sorting nexin 15 Neighboring gene uncharacterized LOC134483958 Neighboring gene ADP-ribosylation factor like GTPase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structural and biochemical characterization of a novel aminopeptidase from human intestine. Tykvart J, et al. J Biol Chem, 2015 May 1. PMID 25752612, Free PMC Article
  2. Cloning and characterization of a novel peptidase from rat and human ileum. Shneider BL, et al. J Biol Chem, 1997 Dec 5. PMID 9388249
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables aminopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables aminopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables carboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in peptide catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in peptide catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in peptide catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
aminopeptidase NAALADL1
Names
100 kDa ileum brush border membrane protein
N-acetylated alpha-linked acidic dipeptidase-like (ileal peptidase I100)
N-acetylated-alpha-linked acidic dipeptidase-like protein
NAALADase L
ileal dipeptidylpeptidase
ileal peptidase I100
NP_113947.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031759.2 → NP_113947.1  aminopeptidase NAALADL1

    See identical proteins and their annotated locations for NP_113947.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    O54697
    UniProtKB/TrEMBL
    A6HZD9, A6HZE0
    Related
    ENSRNOP00000051719.3, ENSRNOT00000054835.4
    Conserved Domains (4) summary
    cd02121
    Location:119 → 331
    PA_GCPII_like; Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to the peptidase ...
    cd08022
    Location:353 → 592
    M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
    pfam04253
    Location:621 → 740
    TFR_dimer; Transferrin receptor-like dimerization domain
    cl14876
    Location:53 → 126
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    212829917..212843474
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O54697.1 GenPept UniProtKB/Swiss-Prot:O54697

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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