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ABCB1 ATP binding cassette subfamily B1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 818265, updated on 7-Sep-2023

Summary

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Gene symbol
ABCB1
Gene description
ATP binding cassette subfamily B1
Primary source
Araport:AT2G36910
Locus tag
AT2G36910
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS THALIANA P GLYCOPROTEIN1; ATP binding cassette subfamily B1; ATP-binding cassette B1; ATPGP1; P-GLYCOPROTEIN 1; PGP1; T1J8.9; T1J8_9
Summary
Belongs to the family of ATP-binding cassette (ABC) transporters. Also known as AtMDR1.Possibly regulates auxin-dependent responses by influencing basipetal auxin transport in the root. Exerts nonredundantly overlapping functions with the ABC transporter encoded by AT3G28860. PGP1 mediates cellular efflux of IAA and interacts with PIN genes that may confer an accelerated vectoral component to PGP-mediated transport. The non-polar localization of PGP1 at root and shoot apices, where IAA gradient-driven transport is impaired, may be required to confer directionality to auxin transport in those tissues.
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Genomic context

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Location:
chromosome: 2
Exon count:
10
Sequence:
Chromosome: 2; NC_003071.7 (15501726..15507501)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene D-tagatose-1,6-bisphosphate aldolase subunit Neighboring gene membrin 11 Neighboring gene B3 domain protein Neighboring gene zinc finger (C2H2 type) family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A twist in the ABC: regulation of ABC transporter trafficking and transport by FK506-binding proteins. Geisler M, et al. FEBS Lett, 2020 Dec. PMID 33125703
  2. Characterization of a dwarf mutant allele of Arabidopsis MDR-like ABC transporter AtPGP1 gene. Ye L, et al. Biochem Biophys Res Commun, 2013 Nov 29. PMID 24211579
  3. The ABC of auxin transport: the role of p-glycoproteins in plant development. Geisler M, et al. FEBS Lett, 2006 Feb 13. PMID 16359667
  4. Cellular efflux of auxin catalyzed by the Arabidopsis MDR/PGP transporter AtPGP1. Geisler M, et al. Plant J, 2005 Oct. PMID 16212599
  5. Involvement of an ABC transporter in a developmental pathway regulating hypocotyl cell elongation in the light. Sidler M, et al. Plant Cell, 1998 Oct. PMID 9761790, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ABCB1 plays a major role during anther development, while ABCB19 has a synergistic role.
    Title: ABCB1 and ABCB19 auxin transporters have synergistic effects on early and late Arabidopsis anther development.
  2. TWD1 controls lateral ABCB1-mediated export into the apoplast, which is required for auxin-mediated cell elongation.
    Title: Expression of TWISTED DWARF1 lacking its in-plane membrane anchor leads to increased cell elongation and hypermorphic growth.
  3. These results suggest a direct involvement of AtPGP1 in auxin transport processes controlling plant growth
    Title: Characterization of a dwarf mutant allele of Arabidopsis MDR-like ABC transporter AtPGP1 gene.
  4. TWD1 promotes lateral ABCB-mediated auxin efflux via protein-protein interaction at the plasma membrane, minimizing reflux from the root apoplast into the cytoplasm.
    Title: Arabidopsis TWISTED DWARF1 functionally interacts with auxin exporter ABCB1 on the root plasma membrane.
  5. Evidence was provided that AGC protein kinase phosphorylation has a dual, counter-active impact on ABCB1 activity that is coordinated by TWD1-PID interaction.
    Title: Regulation of ABCB1/PGP1-catalysed auxin transport by linker phosphorylation.
  6. Data show that root hair cell-specific overexpression of auxin efflux transporter PGP1 decreased root hair elongation.
    Title: P-glycoprotein4 displays auxin efflux transporter-like action in Arabidopsis root hair cells and tobacco cells.
  7. The localization, activity, substrate specificity and inhibitor sensitivity of AtPGP1 are reported.
    Title: Cellular efflux of auxin catalyzed by the Arabidopsis MDR/PGP transporter AtPGP1.
  8. The functional characterization of two closely related ABC (ATP-binding cassette) transporter genes, AtMDR1 and AtPGP1, in light and auxin responses.
    Title: Two homologous ATP-binding cassette transporter proteins, AtMDR1 and AtPGP1, regulate Arabidopsis photomorphogenesis and root development by mediating polar auxin transport.
  9. Immunophilin-like TWISTED DWARF1 modulates auxin efflux activities of Arabidopsis P-glycoprotein
    Title: Immunophilin-like TWISTED DWARF1 modulates auxin efflux activities of Arabidopsis P-glycoproteins.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_129247.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables auxin efflux transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables auxin influx transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within anthocyanin accumulation in tissues in response to UV light IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within auxin export across the plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within auxin polar transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within auxin polar transport TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within photomorphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive gravitropism IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of cell size IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to auxin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to blue light IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to nematode HEP PubMed 
acts_upstream_of_or_within response to red or far red light IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within stamen development IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in plasma membrane HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasmodesma HDA PubMed 

General protein information

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Preferred Names
ATP binding cassette subfamily B1
NP_181228.1
  • ATP binding cassette subfamily B1 (ABCB1); FUNCTIONS IN: ATPase activity, coupled to transmembrane movement of substances, calmodulin binding, auxin efflux transmembrane transporter activity; INVOLVED IN: in 10 processes; LOCATED IN: plasma membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), ABC transporter-like (InterPro:IPR003439), ABC transporter, transmembrane domain, type 1 (InterPro:IPR011527), ABC transporter integral membrane type 1 (InterPro:IPR017940), ABC transporter, transmembrane domain (InterPro:IPR001140), ABC transporter, conserved site (InterPro:IPR017871); BEST Arabidopsis thaliana protein match is: ATP binding cassette subfamily B19 (TAIR:AT3G28860.1); Has 825599 Blast hits to 386427 proteins in 4134 species: Archae - 14573; Bacteria - 644325; Metazoa - 17752; Fungi - 12077; Plants - 9020; Viruses - 35; Other Eukaryotes - 127817 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    15501726..15507501
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_129247.3 → NP_181228.1  ATP binding cassette subfamily B1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_181228.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8L6X6, Q9ZR72
    UniProtKB/TrEMBL
    A0A178VPM1
    Conserved Domains (3) summary
    cd03249
    Location:368 → 607
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    PTZ00265
    Location:43 → 1264
    PTZ00265; multidrug resistance protein (mdr1); Provisional
    pfam00664
    Location:49 → 319
    ABC_membrane; ABC transporter transmembrane region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ZR72.1

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