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Aldh6a1 aldehyde dehydrogenase 6 family, member A1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81708, updated on 5-Mar-2024

Summary

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Official Symbol
Aldh6a1provided by RGD
Official Full Name
aldehyde dehydrogenase 6 family, member A1provided by RGD
Primary source
RGD:621556
See related
Ensembl:ENSRNOG00000011419 AllianceGenome:RGD:621556
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mmsdh
Summary
Enables malonate-semialdehyde dehydrogenase (acetylating) activity; methylmalonate-semialdehyde dehydrogenase (acylating) activity; and thiolester hydrolase activity. Involved in beta-alanine catabolic process; thymine catabolic process; and valine catabolic process. Predicted to be located in nucleoplasm. Predicted to be active in mitochondrion. Orthologous to human ALDH6A1 (aldehyde dehydrogenase 6 family member A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 2899.5), Liver (RPKM 1598.1) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Aldh6a1 in Genome Data Viewer
Location:
6q31
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (109809092..109829725, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (104077975..104098636, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (108146552..108167185, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene coenzyme Q6 monooxygenase Neighboring gene ectonucleoside triphosphate diphosphohydrolase 5 Neighboring gene ring finger protein 113A2 Neighboring gene basal body orientation factor 1 Neighboring gene lin-52 DREAM MuvB core complex component Neighboring gene visual system homeobox 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Epididymosome-mediated acquisition of MMSDH, an androgen-dependent and developmentally regulated epididymal sperm protein. Suryawanshi AR, et al. J Androl, 2012 Sep-Oct. PMID 22207704
  2. Purification and characterization of methylmalonate-semialdehyde dehydrogenase from rat liver. Identity to malonate-semialdehyde dehydrogenase. Goodwin GW, et al. J Biol Chem, 1989 Sep 5. PMID 2768248
  3. The effect of ligand binding on the proteolytic pattern of methylmalonate semialdehyde dehydrogenase. Kedishvili NY, et al. Arch Biochem Biophys, 1991 Oct. PMID 1898092
  4. Coenzyme A- and NADH-dependent esterase activity of methylmalonate semialdehyde dehydrogenase. Popov KM, et al. Biochim Biophys Acta, 1992 Feb 13. PMID 1540637
  5. Mutations in ALDH6A1 encoding methylmalonate semialdehyde dehydrogenase are associated with dysmyelination and transient methylmalonic aciduria. Marcadier JL, et al. Orphanet J Rare Dis, 2013 Jul 9. PMID 23835272, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Suggest that MMSDH protein is present in the entire epididymis; its expression is regulated by androgen and the developmental status of the epididymis.
    Title: Epididymosome-mediated acquisition of MMSDH, an androgen-dependent and developmentally regulated epididymal sperm protein.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables malonate-semialdehyde dehydrogenase (acetylating) activity IEA
Inferred from Electronic Annotation
more info
  
enables methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity IEA
Inferred from Electronic Annotation
more info
  
enables methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity ISO
Inferred from Sequence Orthology
more info
  
enables methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables thiolester hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in beta-alanine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in brown fat cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within brown fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in thymine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in thymine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in thymine catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in thymine catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in thymine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in valine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in valine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in valine catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in valine catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in valine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial
Names
aldehyde dehydrogenase family 6 member A1
aldehyde dehydrogenase family 6, subfamily A1
malonate-semialdehyde dehydrogenase
methylmalonate semialdehyde dehydrogenase
methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
NP_112319.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031057.2 → NP_112319.2  methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial precursor

    See identical proteins and their annotated locations for NP_112319.2

    Status: VALIDATED

    Source sequence(s)
    AA819519, CB760062, CK474421, CK476335, CV797088, DN948946, M93401
    UniProtKB/Swiss-Prot
    Q02253
    UniProtKB/TrEMBL
    A6JDW8, G3V7J0
    Related
    ENSRNOP00000015545.3, ENSRNOT00000015545.5
    Conserved Domains (1) summary
    cd07085
    Location:40 → 516
    ALDH_F6_MMSDH; Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    109809092..109829725 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02253.1 GenPept UniProtKB/Swiss-Prot:Q02253

Gene LinkOut

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