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APC2 anaphase-promoting complex/cyclosome 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 815008, updated on 15-Oct-2023

Summary

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Gene symbol
APC2
Gene description
anaphase-promoting complex/cyclosome 2
Primary source
Araport:AT2G04660
Locus tag
AT2G04660
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
anaphase-promoting complex/cyclosome 2; F28I8.30; F28I8_30
Summary
a highly conserved ubiquitin-protein ligase involved in cell cycle regulation
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Genomic context

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Location:
chromosome: 2
Exon count:
16
Sequence:
Chromosome: 2; NC_003071.7 (1624630..1629259)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene RNA polymerase Rpb6 Neighboring gene ADP-glucose pyrophosphorylase family protein Neighboring gene pseudo Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genomic evolution and complexity of the Anaphase-promoting Complex (APC) in land plants. Lima Mde F, et al. BMC Plant Biol, 2010 Nov 18. PMID 21087491, Free PMC Article
  2. Specialization of CDC27 function in the Arabidopsis thaliana anaphase-promoting complex (APC/C). Pérez-Pérez JM, et al. Plant J, 2008 Jan. PMID 17944809
  3. The Arabidopsis anaphase-promoting complex or cyclosome: molecular and genetic characterization of the APC2 subunit. Capron A, et al. Plant Cell, 2003 Oct. PMID 14508008, Free PMC Article
  4. Protein degradation in signaling. Callis J, et al. Curr Opin Plant Biol, 2000 Oct. PMID 11019805
  5. Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana. Van Leene J, et al. Mol Syst Biol, 2010 Aug 10. PMID 20706207, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_126495.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in megagametogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ubiquitin ligase complex TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
anaphase-promoting complex/cyclosome 2
NP_178543.2
  • anaphase-promoting complex/cyclosome 2 (APC2); FUNCTIONS IN: ubiquitin-protein ligase activity, ubiquitin protein ligase binding; INVOLVED IN: ubiquitin-dependent protein catabolic process; LOCATED IN: ubiquitin ligase complex; EXPRESSED IN: 12 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Cullin homology (InterPro:IPR016158), Anaphase promoting complex subunit 2 (InterPro:IPR014786), Cullin, N-terminal (InterPro:IPR001373); BEST Arabidopsis thaliana protein match is: cullin4 (TAIR:AT5G46210.1); Has 1400 Blast hits to 1393 proteins in 217 species: Archae - 0; Bacteria - 0; Metazoa - 534; Fungi - 454; Plants - 255; Viruses - 0; Other Eukaryotes - 157 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    1624630..1629259
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_126495.3 → NP_178543.2  anaphase-promoting complex/cyclosome 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_178543.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8GX39, Q8H1U5, Q9SJ93
    UniProtKB/TrEMBL
    A0A178VYA9, A0A5S9WX64, A0A7G2E7I0
    Conserved Domains (2) summary
    pfam00888
    Location:557 → 735
    Cullin; Cullin family
    pfam08672
    Location:804 → 863
    ANAPC2; Anaphase promoting complex (APC) subunit 2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8H1U5.1

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