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Gpr63 G protein-coupled receptor 63 [ Mus musculus (house mouse) ]

Gene ID: 81006, updated on 21-Apr-2024

Summary

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Official Symbol
Gpr63provided by MGI
Official Full Name
G protein-coupled receptor 63provided by MGI
Primary source
MGI:MGI:2135884
See related
Ensembl:ENSMUSG00000040372 AllianceGenome:MGI:2135884
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Psp24-2; PSP24beta
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Is expressed in gut; male reproductive gland or organ; metanephros; nervous system; and thymus. Orthologous to human GPR63 (G protein-coupled receptor 63). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 4.1), CNS E18 (RPKM 1.2) and 14 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 A3; 4 10.53 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (24966054..25012726)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (24966054..25009238)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31379 Neighboring gene STARR-seq mESC enhancer starr_09783 Neighboring gene predicted gene, 46848 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 4 Neighboring gene RIKEN cDNA C230012O17 gene Neighboring gene four and a half LIM domains 5 Neighboring gene UFM1 specific ligase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Gpr63 is a modifier of microcephaly in Ttc21b mouse mutants. Snedeker J, et al. PLoS Genet, 2019 Nov. PMID 31730647, Free PMC Article
  2. Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45. Kawasawa Y, et al. Biochem Biophys Res Commun, 2000 Oct 5. PMID 11027574
  3. Atlas of gene expression in the developing kidney at microanatomic resolution. Brunskill EW, et al. Dev Cell, 2008 Nov. PMID 19000842, Free PMC Article
  4. Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Ghai R, et al. Proc Natl Acad Sci U S A, 2013 Feb 19. PMID 23382219, Free PMC Article
  5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
probable G-protein coupled receptor 63
Names
G protein-coupled receptor PSP24-2
PSP24-beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379626.1 → NP_001366555.1  probable G-protein coupled receptor 63

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AL772199, AL772223
    UniProtKB/Swiss-Prot
    Q8BZ93, Q9EQQ3
    Conserved Domains (1) summary
    cd15404
    Location:88 → 388
    7tmA_GPR63; G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001379627.1 → NP_001366556.1  probable G-protein coupled receptor 63

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AL772199, AL772223
    UniProtKB/Swiss-Prot
    Q8BZ93, Q9EQQ3
    Conserved Domains (1) summary
    cd15404
    Location:88 → 388
    7tmA_GPR63; G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. NM_030733.4 → NP_109658.2  probable G-protein coupled receptor 63

    See identical proteins and their annotated locations for NP_109658.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 all encode the same protein.
    Source sequence(s)
    AL772199, AL772223
    Consensus CDS
    CCDS18008.1
    UniProtKB/Swiss-Prot
    Q8BZ93, Q9EQQ3
    Related
    ENSMUSP00000039312.2, ENSMUST00000038920.2
    Conserved Domains (1) summary
    cd15404
    Location:88 → 388
    7tmA_GPR63; G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    24966054..25012726
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538383.5 → XP_006538446.1  probable G-protein coupled receptor 63 isoform X1

    See identical proteins and their annotated locations for XP_006538446.1

    UniProtKB/Swiss-Prot
    Q8BZ93, Q9EQQ3
    Conserved Domains (1) summary
    cd15404
    Location:88 → 388
    7tmA_GPR63; G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EQQ3.2 GenPept UniProtKB/Swiss-Prot:Q9EQQ3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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