Kcnip2 Kv channel-interacting protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcnip2provided by MGI
Official Full Name: Kv channel-interacting protein 2provided by MGI
Primary source: MGI:MGI:2135916
See related: Ensembl:ENSMUSG00000025221 AllianceGenome:MGI:2135916
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: KChIP2
Summary: This gene encodes a member of the voltage-gated potassium channel-interacting protein (KCNIP) family. KCNIP family members are small calcium binding proteins that commonly exhibit unique variation at their N-termini, and which modulate A-type potassium channels. This gene is predominantly expressed in the adult heart, and to a lesser extent in the brain. Disruption of this gene is associated with susceptibility to cardiac arrhythmias and lack of transient outward potassium current in ventricular myocytes, and downregulated expression is associated with cardiac hypertrophy. The encoded protein has also been implicated as a repressor of immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]
Expression: Biased expression in heart adult (RPKM 60.6), cortex adult (RPKM 30.5) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C3; 19 38.75 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (45780785..45804948, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (45792346..45816422, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibitory Kcnip2 neurons of the spinal dorsal horn control behavioral sensitivity to environmental cold.
Title: Inhibitory Kcnip2 neurons of the spinal dorsal horn control behavioral sensitivity to environmental cold.
A Soluble Epoxide Hydrolase Inhibitor Upregulated KCNJ12 and KCNIP2 by Downregulating MicroRNA-29 in a Mouse Model of Myocardial Infarction.
Title: A Soluble Epoxide Hydrolase Inhibitor Upregulated KCNJ12 and KCNIP2 by Downregulating MicroRNA-29 in a Mouse Model of Myocardial Infarction.
These findings establish MG53 as a novel regulator of KChIP2 and Ito,f by modulating NF-kappaB activity and reveal its critical role in electrophysiological remodeling in cardiac hypertrophy.
Title: MG53, A Novel Regulator of KChIP2 and I(to,f), Plays a Critical Role in Electrophysiological Remodeling in Cardiac Hypertrophy.
we are investigating the effects of hyperoxia on atrial electrophysiology using whole-cell patch-clamp electrophysiology experiments along with assessment of Kv1.5, Kv4.2, and KChIP2 transcripts and protein profiles using real-time quantitative RT-PCR and Western blotting.
Title: Elevated potassium outward currents in hyperoxia treated atrial cardiomyocytes.
although there is a baseline presence of KChIP2 in the nucleus both in vivo and in vitro, KChIP2 does not directly regulate transcriptional activity. Moreover, the nuclear transport of KChIP2 is not dependent on Ca(2+). Thus, KChIP2 does not function as a conventional transcription factor in the heart.
Title: Potassium Channel Interacting Protein 2 (KChIP2) is not a transcriptional regulator of cardiac electrical remodeling.
KChIP2 expression does not appear to underlie the circadian rhythm in repolarization duration.
Title: Circadian rhythm in QT interval is preserved in mice deficient of potassium channel interacting protein 2.
the Kv4.2/KChIP2 interaction in cardiomyocytes is highly dynamic, with a clear KChIP2 gene dosage effect on Kv4 channel surface expression but not on inactivation gating.
Title: KChIP2 genotype dependence of transient outward current (Ito) properties in cardiomyocytes isolated from male and female mice.
The downregulation of repolarizing currents in heart failure is accentuated in KChIP2(-/-) mice.
Title: Loss of K+ currents in heart failure is accentuated in KChIP2 deficient mice.
Real-time RT-PCR and Western blotting revealed that Kv4.2 expression was downregulated in both BSO-treated groups, whereas KChIP2 expression was downregulated only in the H/M-Sod2(+/-)+BSO group (P<0.05).
Title: Cardiomyocyte-derived mitochondrial superoxide causes myocardial electrical remodeling by downregulating potassium channels and related molecules.
Development of heart failure is independent of K+ channel-interacting protein 2 expression.
Title: Development of heart failure is independent of K+ channel-interacting protein 2 expression.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI059157 (e-PCR)
- UniSTS:244513

MARC_12017-12018:1003953684:1 (e-PCR)
- UniSTS:267309

AI431055 (e-PCR)
- UniSTS:160846

NoName (e-PCR)
- UniSTS:237962

Kcnip2 (e-PCR), detects polymorphism
- UniSTS:547251

Kcnip2 (e-PCR), detects polymorphism
- UniSTS:478917

Kcnip2 (e-PCR), detects polymorphism
- UniSTS:478918

Kcnip2 (e-PCR), detects polymorphism
- UniSTS:478919

AI851528 (e-PCR)
- UniSTS:181245

AW050122 (e-PCR)
- UniSTS:181246

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to A-type (transient outward) potassium channel activity	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables potassium channel activity	IEA Inferred from Electronic Annotation more info
enables potassium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables potassium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in action potential	ISO Inferred from Sequence Orthology more info
involved_in clustering of voltage-gated potassium channels	ISO Inferred from Sequence Orthology more info
involved_in membrane repolarization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of potassium ion export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in potassium ion export across plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of heart contraction	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of potassium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Kv4.2-KChIP2 channel complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: Kv channel-interacting protein 2

Names: A-type potassium channel modulatory protein 2; potassium channel-interacting protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001276358.1 → NP_001263287.1 Kv channel-interacting protein 2 isoform d

See identical proteins and their annotated locations for NP_001263287.1

Status: REVIEWED

Description

Transcript Variant: This variant (d) uses an alternate 5' exon structure, lacks an in-frame segment in the coding region, and initiates translation at an alternate start codon, compared to variant a. The encoded isoform (d) has a distinct N-terminus and is shorter than isoform a.

Source sequence(s)

AY647241, BC056434

Consensus CDS

CCDS70955.1

UniProtKB/TrEMBL

Q3YAA4

Related

ENSMUSP00000084215.5, ENSMUST00000086993.11

Conserved Domains (1) summary

COG5126
Location:48 → 214

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
NM_001424873.1 → NP_001411802.1 Kv channel-interacting protein 2 isoform e

Status: REVIEWED

Source sequence(s)

AC149086

UniProtKB/TrEMBL

A0A5F8MPB0
NM_030716.3 → NP_109641.2 Kv channel-interacting protein 2 isoform b

See identical proteins and their annotated locations for NP_109641.2

Status: REVIEWED

Description

Transcript Variant: This variant (b) lacks an internal exon in the coding region but maintains the reading frame, compared to variant a. The encoded isoform (b) is shorter, compared to isoform a.

Source sequence(s)

BC056434, CX122626, DQ148497

Consensus CDS

CCDS50453.1

UniProtKB/TrEMBL

E9QNK8, Q3YAB2

Related

ENSMUSP00000078400.4, ENSMUST00000079431.10

Conserved Domains (1) summary

COG5126
Location:75 → 241

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
NM_145703.2 → NP_663749.1 Kv channel-interacting protein 2 isoform a

See identical proteins and their annotated locations for NP_663749.1

Status: REVIEWED

Description

Transcript Variant: This variant (a) represents the longest transcript and encodes the longest isoform (a, also known as KCHIP2L).

Source sequence(s)

BC056434, CX122626, DQ148496

Consensus CDS

CCDS38004.1

UniProtKB/Swiss-Prot

Q6DTJ2, Q8K1T8, Q8K1T9, Q8K1U0, Q8VHN4, Q8VHN5, Q8VHN6, Q9JJ68, Q9JJ69

UniProtKB/TrEMBL

Q3YAB3

Related

ENSMUSP00000125142.3, ENSMUST00000162528.9

Conserved Domains (1) summary

COG5126
Location:93 → 259

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
NM_145704.2 → NP_663750.1 Kv channel-interacting protein 2 isoform c

See identical proteins and their annotated locations for NP_663750.1

Status: REVIEWED

Description

Transcript Variant: This variant (c) lacks two consecutive internal exons in the coding region but maintains the reading frame, compared to variant a. The encoded isoform (c, also known as KCHIP2S) is shorter, compared to isoform a.

Source sequence(s)

BC056434, BC138496, CX122626

Consensus CDS

CCDS29868.1

UniProtKB/TrEMBL

E0CY54, E9QNK8, Q3YAB1

Related

ENSMUSP00000124482.3, ENSMUST00000161886.9

Conserved Domains (1) summary

COG5126
Location:43 → 209

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

45780785..45804948 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006527470.5 → XP_006527533.1 Kv channel-interacting protein 2 isoform X3

UniProtKB/Swiss-Prot

Q6DTJ2, Q8K1T8, Q8K1T9, Q8K1U0, Q8VHN4, Q8VHN5, Q8VHN6, Q9JJ68, Q9JJ69

Conserved Domains (1) summary

COG5126
Location:109 → 275

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
XM_017318315.3 → XP_017173804.1 Kv channel-interacting protein 2 isoform X1

UniProtKB/Swiss-Prot

Q6DTJ2, Q8K1T8, Q8K1T9, Q8K1U0, Q8VHN4, Q8VHN5, Q8VHN6, Q9JJ68, Q9JJ69

UniProtKB/TrEMBL

Q3YAB3

Conserved Domains (1) summary

COG5126
Location:93 → 259

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]