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Zfp202 zinc finger protein 202 [ Mus musculus (house mouse) ]

Gene ID: 80902, updated on 5-Mar-2024

Summary

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Official Symbol
Zfp202provided by MGI
Official Full Name
zinc finger protein 202provided by MGI
Primary source
MGI:MGI:1933401
See related
Ensembl:ENSMUSG00000025602 AllianceGenome:MGI:1933401
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf202; C130037E22Rik
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in chromosome; nuclear body; and nucleolus. Is expressed in allantois; foregut diverticulum; genitourinary system; and neural fold. Orthologous to human ZNF202 (zinc finger protein 202). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 1.6), CNS E14 (RPKM 1.6) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A5.1; 9 21.42 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (40103612..40124900)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (40192316..40213604)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene Fcf1 pseudogene Neighboring gene olfactory receptor family 6 subfamily X member 1 Neighboring gene STARR-seq mESC enhancer starr_23849 Neighboring gene STARR-seq mESC enhancer starr_23851 Neighboring gene sodium channel, voltage-gated, type III, beta Neighboring gene GRAM domain containing 1B Neighboring gene RIKEN cDNA 1700110K17 gene Neighboring gene STARR-seq mESC enhancer starr_23853

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Znf202 affects high density lipoprotein cholesterol levels and promotes hepatosteatosis in hyperlipidemic mice. Vrins CL, et al. PLoS One, 2013. PMID 23469003, Free PMC Article
  2. SOX17 directly activates Zfp202 transcription during in vitro endoderm differentiation. Patterson ES, et al. Physiol Genomics, 2008 Aug 15. PMID 18523156
  3. Identification of SCAN dimerization domains in four gene families. Honer C, et al. Biochim Biophys Acta, 2001 Feb 16. PMID 11342224
  4. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein 202
Names
zinc finger 202

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359464.1 → NP_001346393.1  zinc finger protein 202 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC135353, AC136021
    Consensus CDS
    CCDS90536.1
    UniProtKB/TrEMBL
    E9Q2D3
    Related
    ENSMUSP00000132131.2, ENSMUST00000168832.2
    Conserved Domains (2) summary
    smart00431
    Location:43 → 153
    SCAN; leucine rich region
    cl02581
    Location:237 → 277
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  2. NM_030713.2 → NP_109638.2  zinc finger protein 202 isoform 1

    See identical proteins and their annotated locations for NP_109638.2

    Status: VALIDATED

    Source sequence(s)
    AC135353, AC136021, BC049772
    Consensus CDS
    CCDS23079.1
    UniProtKB/TrEMBL
    Q8C879
    Related
    ENSMUSP00000026693.8, ENSMUST00000026693.14
    Conserved Domains (4) summary
    smart00431
    Location:43 → 153
    SCAN; leucine rich region
    smart00349
    Location:237 → 297
    KRAB; krueppel associated box
    COG5048
    Location:332 → 624
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:393 → 413
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. NR_153114.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC135353, AC136021
    Related
    ENSMUST00000168691.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    40103612..40124900
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242629.4 → XP_011240931.1  zinc finger protein 202 isoform X1

    See identical proteins and their annotated locations for XP_011240931.1

    UniProtKB/TrEMBL
    Q8C879
    Conserved Domains (4) summary
    smart00431
    Location:43 → 153
    SCAN; leucine rich region
    smart00349
    Location:237 → 297
    KRAB; krueppel associated box
    COG5048
    Location:332 → 624
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:393 → 413
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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