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ZC3H14 zinc finger CCCH-type containing 14 [ Homo sapiens (human) ]

Gene ID: 79882, updated on 11-Apr-2024

Summary

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Official Symbol
ZC3H14provided by HGNC
Official Full Name
zinc finger CCCH-type containing 14provided by HGNC
Primary source
HGNC:HGNC:20509
See related
Ensembl:ENSG00000100722 MIM:613279; AllianceGenome:HGNC:20509
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SUT2; MRT56; UKp68; MSUT-2; NY-REN-37
Summary
The protein encoded by this gene is a poly(A)-binding protein that can affect gene expression and poly(A) tail length. The encoded protein may influence mRNA stability, nuclear export, and translation. [provided by RefSeq, May 2016]
Expression
Broad expression in testis (RPKM 19.6), thyroid (RPKM 8.3) and 25 other tissues See more
Orthologs
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Genomic context

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See ZC3H14 in Genome Data Viewer
Location:
14q31.3
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (88563037..88627596)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (82783861..82848491)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (89029381..89093940)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370614 Neighboring gene protein tyrosine phosphatase non-receptor type 21 Neighboring gene RNA, U4 small nuclear 22, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:89015655-89016472 Neighboring gene proline-rich protein 2-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5991 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5992 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8842 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:89084698-89085319 Neighboring gene EMAP like 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8843 Neighboring gene MPRA-validated peak2226 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5993 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8844 Neighboring gene RNA, U4 small nuclear 92, pseudogene Neighboring gene tetratricopeptide repeat domain 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. AlphaScreen Identifies MSUT2 Inhibitors for Tauopathy-Targeting Therapeutic Discovery. Baker JD, et al. SLAS Discov, 2021 Mar. PMID 32981422, Free PMC Article
  2. Downregulation of ZC3H14 driven by chromosome 14q31 deletion promotes hepatocellular carcinoma progression by activating integrin signaling. Zhang C, et al. Carcinogenesis, 2019 May 14. PMID 30371740
  3. The Polyadenosine RNA-binding Protein, Zinc Finger Cys3His Protein 14 (ZC3H14), Regulates the Pre-mRNA Processing of a Key ATP Synthase Subunit mRNA. Wigington CP, et al. J Biol Chem, 2016 Oct 21. PMID 27563065, Free PMC Article
  4. A conserved role for the zinc finger polyadenosine RNA binding protein, ZC3H14, in control of poly(A) tail length. Kelly SM, et al. RNA, 2014 May. PMID 24671764, Free PMC Article
  5. MSUT2 is a determinant of susceptibility to tau neurotoxicity. Guthrie CR, et al. Hum Mol Genet, 2011 May 15. PMID 21355046, Free PMC Article

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AlphaScreen Identifies MSUT2 Inhibitors for Tauopathy-Targeting Therapeutic Discovery.
    Title: AlphaScreen Identifies MSUT2 Inhibitors for Tauopathy-Targeting Therapeutic Discovery.
  2. study suggests that ZC3H14 functions as a novel tumor suppressor and is a candidate prognostic biomarker for hepatocellular carcinoma patients
    Title: Downregulation of ZC3H14 driven by chromosome 14q31 deletion promotes hepatocellular carcinoma progression by activating integrin signaling.
  3. ATP5G1 turnover increases upon depletion of ZC3H14, double knockdown of ZC3H14 and the nonsense-mediated decay factor, UPF1, rescues ATP5G1 transcript levels. Furthermore, fractionation reveals an increase in the amount of ATP5G1 pre-mRNA that reaches the cytoplasm when ZC3H14 is depleted and that ZC3H14 binds to ATP5G1 pre-mRNA in the nucleus.
    Title: The Polyadenosine RNA-binding Protein, Zinc Finger Cys3His Protein 14 (ZC3H14), Regulates the Pre-mRNA Processing of a Key ATP Synthase Subunit mRNA.
  4. we show here that human ZC3H14 can functionally substitute for dNab2 in fly neurons and can rescue defects in development and locomotion that are present in dNab2 null flies
    Title: A conserved role for the zinc finger polyadenosine RNA binding protein, ZC3H14, in control of poly(A) tail length.
  5. report a intellectual disability disease locus on chromosome 14q31.3 corresponding to mutation of the ZC3H14 gene that encodes a conserved polyadenosine RNA binding protein
    Title: Mutation of the conserved polyadenosine RNA binding protein, ZC3H14/dNab2, impairs neural function in Drosophila and humans.
  6. MSUT2 levels may influence neuronal vulnerability to tau toxicity and aggregation.
    Title: MSUT2 is a determinant of susceptibility to tau neurotoxicity.
  7. New neuroprotective strategies targeting MSUT-2 that may be effective in modulating tau neurotoxicity in human tauopathy disorders.
    Title: The role of MSUT-2 in tau neurotoxicity: a target for neuroprotection in tauopathy?
  8. multiple transcripts encoding several ZC3H14 isoforms exist in vivo
    Title: Splice variants of the human ZC3H14 gene generate multiple isoforms of a zinc finger polyadenosine RNA binding protein.
  9. these proteins are members of an evolutionarily conserved family of poly(A) RNA binding proteins
    Title: Recognition of polyadenosine RNA by zinc finger proteins.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Intellectual disability, autosomal recessive 56
MedGen: C4310703 OMIM: 617125 GeneReviews: Not available
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ11806, MGC26892

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(A) binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of mRNA stability IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in axon cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger CCCH domain-containing protein 14
Names
mammalian suppressor of tau pathology-2
nuclear protein UKp68
renal carcinoma antigen NY-REN-37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050601.2 RefSeqGene

    Range
    5002..69561
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001160103.2 → NP_001153575.1  zinc finger CCCH domain-containing protein 14 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The resulting isoform (5) lacks one-aa near the C-terminus, compared to isoform 1.
    Source sequence(s)
    AL162171, AL359625, BC011793, BC023641, BC034274, BX248769, DB452844
    UniProtKB/TrEMBL
    H0YJA2
    Conserved Domains (1) summary
    pfam14608
    Location:621 → 639
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger

  2. NM_001160104.2 → NP_001153576.1  zinc finger CCCH domain-containing protein 14 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses two alternate in-frame splice sites in the 3' coding region, compared to variant 1. The resulting isoform (6) lacks a five-aa and a one-aa segment, compared to isoform 1.
    Source sequence(s)
    AK304275, AL162171, AL359625, BC011793, BC034274, BX248769, DB452844
    Consensus CDS
    CCDS55938.1
    UniProtKB/TrEMBL
    H0YJA2
    Related
    ENSP00000452475.1, ENST00000555755.5
    Conserved Domains (1) summary
    pfam14608
    Location:616 → 634
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger

  3. NM_001326295.2 → NP_001313224.1  zinc finger CCCH domain-containing protein 14 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL162171
    Consensus CDS
    CCDS86417.1
    UniProtKB/TrEMBL
    G3V256
    Related
    ENSP00000450474.1, ENST00000556945.5
    Conserved Domains (1) summary
    pfam14608
    Location:551 → 567
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger

  4. NM_001326296.2 → NP_001313225.1  zinc finger CCCH domain-containing protein 14 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL162171
    UniProtKB/TrEMBL
    H0YJA2

  5. NM_001326297.2 → NP_001313226.1  zinc finger CCCH domain-containing protein 14 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL162171
    UniProtKB/TrEMBL
    H0YJA2
    Conserved Domains (1) summary
    pfam14608
    Location:587 → 605
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger

  6. NM_001326298.2 → NP_001313227.1  zinc finger CCCH domain-containing protein 14 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL162171
    Conserved Domains (1) summary
    pfam14608
    Location:526 → 542
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger

  7. NM_001326299.2 → NP_001313228.1  zinc finger CCCH domain-containing protein 14 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL162171
    UniProtKB/TrEMBL
    H0YJA2

  8. NM_001326300.2 → NP_001313229.1  zinc finger CCCH domain-containing protein 14 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AL162171
    UniProtKB/TrEMBL
    H0YJA2
    Conserved Domains (1) summary
    pfam14608
    Location:527 → 543
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger

  9. NM_001326301.2 → NP_001313230.1  zinc finger CCCH domain-containing protein 14 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AL162171
    UniProtKB/TrEMBL
    H0YJA2

  10. NM_001326302.2 → NP_001313231.1  zinc finger CCCH domain-containing protein 14 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AL162171
    UniProtKB/TrEMBL
    H0YJA2
    Related
    ENSP00000451054.1, ENST00000556000.5
    Conserved Domains (1) summary
    pfam14608
    Location:526 → 542
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger

  11. NM_001326303.2 → NP_001313232.1  zinc finger CCCH domain-containing protein 14 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AL162171
    Conserved Domains (1) summary
    pfam14608
    Location:491 → 507
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger

  12. NM_001326304.2 → NP_001313233.1  zinc finger CCCH domain-containing protein 14 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AL162171
    UniProtKB/TrEMBL
    G3V5I6

  13. NM_001326305.2 → NP_001313234.1  zinc finger CCCH domain-containing protein 14 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AL162171
    UniProtKB/TrEMBL
    H0YJA2
    Conserved Domains (1) summary
    pfam14608
    Location:502 → 518
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger

  14. NM_001326306.2 → NP_001313235.1  zinc finger CCCH domain-containing protein 14 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AL162171
    Conserved Domains (1) summary
    pfam14608
    Location:473 → 489
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger

  15. NM_001326307.2 → NP_001313236.1  zinc finger CCCH domain-containing protein 14 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AL162171
    Consensus CDS
    CCDS86418.1
    UniProtKB/TrEMBL
    H0YJA2
    Related
    ENSP00000377150.5, ENST00000393514.9
    Conserved Domains (1) summary
    pfam14608
    Location:596 → 614
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger

  16. NM_001326308.2 → NP_001313237.1  zinc finger CCCH domain-containing protein 14 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AL162171
    UniProtKB/TrEMBL
    G3V5I6

  17. NM_001326309.2 → NP_001313238.1  zinc finger CCCH domain-containing protein 14 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AL162171
    UniProtKB/TrEMBL
    G3V5I6

  18. NM_001326310.2 → NP_001313239.1  zinc finger CCCH domain-containing protein 14 isoform 22

    Status: REVIEWED

    Source sequence(s)
    AL162171
    UniProtKB/TrEMBL
    H0YJA2
    Conserved Domains (1) summary
    pfam14608
    Location:616 → 634
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger

  19. NM_001326311.2 → NP_001313240.1  zinc finger CCCH domain-containing protein 14 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AL162171
    UniProtKB/TrEMBL
    G3V5I6
    Related
    ENSP00000452370.1, ENST00000557607.5

  20. NM_001326312.2 → NP_001313241.1  zinc finger CCCH domain-containing protein 14 isoform 24

    Status: REVIEWED

    Source sequence(s)
    AL162171
    UniProtKB/TrEMBL
    H0YJA2

  21. NM_001326313.2 → NP_001313242.1  zinc finger CCCH domain-containing protein 14 isoform 25

    Status: REVIEWED

    Source sequence(s)
    AL162171
    Conserved Domains (1) summary
    pfam14608
    Location:474 → 490
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger

  22. NM_001326314.2 → NP_001313243.1  zinc finger CCCH domain-containing protein 14 isoform 26

    Status: REVIEWED

    Source sequence(s)
    AL162171
    UniProtKB/TrEMBL
    H0YJA2
    Conserved Domains (1) summary
    pfam14608
    Location:501 → 517
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger

  23. NM_001326315.2 → NP_001313244.1  zinc finger CCCH domain-containing protein 14 isoform 27

    Status: REVIEWED

    Description
    Transcript Variant: This variant (27) and variant 28 both encode the same isoform (27).
    Source sequence(s)
    AL162171
    UniProtKB/TrEMBL
    H0YJA2

  24. NM_001326316.2 → NP_001313245.1  zinc finger CCCH domain-containing protein 14 isoform 27

    Status: REVIEWED

    Description
    Transcript Variant: This variant (28) and variant 27 both encode the same isoform (27).
    Source sequence(s)
    AL162171
    UniProtKB/TrEMBL
    H0YJA2

  25. NM_024824.5 → NP_079100.2  zinc finger CCCH domain-containing protein 14 isoform 1

    See identical proteins and their annotated locations for NP_079100.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL162171, AL359625, BC011793, BC034274, BX248769, DB452844
    Consensus CDS
    CCDS32133.1
    UniProtKB/Swiss-Prot
    A8MY46, B4DXU8, B4DZW7, B4E2H4, G3V5R4, Q6MZU4, Q6PJ32, Q6PJT7, Q6PUI6, Q6PUI8, Q86TQ5, Q86TW0, Q86TW1, Q8NCT6, Q8NCZ3, Q8TDE2, Q9HAC9, Q9Y5A0
    UniProtKB/TrEMBL
    H0YJA2
    Related
    ENSP00000251038.5, ENST00000251038.10
    Conserved Domains (1) summary
    pfam14608
    Location:621 → 639
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger

  26. NM_207660.4 → NP_997543.1  zinc finger CCCH domain-containing protein 14 isoform 2

    See identical proteins and their annotated locations for NP_997543.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks three alternate exons in the central coding region and uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment and one-aa near the C-terminus, compared to isoform 1.
    Source sequence(s)
    AL162171, AL359625, AY578061, BC034274, BX248769
    Consensus CDS
    CCDS32134.1
    UniProtKB/Swiss-Prot
    Q6PJT7
    Related
    ENSP00000307025.8, ENST00000302216.12

  27. NM_207661.3 → NP_997544.1  zinc finger CCCH domain-containing protein 14 isoform 3

    See identical proteins and their annotated locations for NP_997544.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents use of an alternate promoter, uses a downstream start codon, and lacks two alternate exons in the central coding region, compared to variant 1. The resulting isoform (3) has a shorter N-terminus and lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AF474376, AL162171, AY578062, BC034274, BX248769
    Consensus CDS
    CCDS32135.1
    UniProtKB/Swiss-Prot
    Q6PJT7
    Related
    ENSP00000338002.4, ENST00000336693.8
    Conserved Domains (1) summary
    pfam14608
    Location:517 → 533
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger

  28. NM_207662.4 → NP_997545.2  zinc finger CCCH domain-containing protein 14 isoform 4

    See identical proteins and their annotated locations for NP_997545.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents use of an alternate promoter, lacks two alternate exons in the central coding region, and uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus, and lacks an internal segment and one-aa near the C-terminus, compared to isoform 1.
    Source sequence(s)
    AL162171, AL359625, BC027607, BC034274, BX248769, DB050247
    Consensus CDS
    CCDS32136.1
    UniProtKB/Swiss-Prot
    Q6PJT7
    Related
    ENSP00000327176.6, ENST00000318308.10
    Conserved Domains (1) summary
    pfam14608
    Location:252 → 268
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger

RNA

  1. NR_136936.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL162171

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    88563037..88627596
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537162.4 → XP_011535464.1  zinc finger CCCH domain-containing protein 14 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    82783861..82848491
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054376723.1 → XP_054232698.1  zinc finger CCCH domain-containing protein 14 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PJT7.1 GenPept UniProtKB/Swiss-Prot:Q6PJT7

Gene LinkOut

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