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spint1b serine peptidase inhibitor, Kunitz type 1 b [ Danio rerio (zebrafish) ]

Gene ID: 797346, updated on 27-Mar-2024

Summary

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Official Symbol
spint1bprovided by ZNC
Official Full Name
serine peptidase inhibitor, Kunitz type 1 bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-071218-1
See related
Ensembl:ENSDARG00000012467 AllianceGenome:ZFIN:ZDB-GENE-071218-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within epidermis development. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in gut; lateral line primordium; and primitive olfactory epithelium. Orthologous to human SPINT1 (serine peptidase inhibitor, Kunitz type 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 20
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (3218893..3238079, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (3201392..3220578, complement)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene centrosomal protein 170Bb Neighboring gene pleckstrin homology and RhoGEF domain containing G3 Neighboring gene ribosomal protein S6 kinase polypeptide 1 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Skin exposure to micro- and nano-particles can cause haemostasis in zebrafish larvae. McLeish JA, et al. Thromb Haemost, 2010 Apr. PMID 20174755
  2. Inactivation of serine protease Matriptase1a by its inhibitor Hai1 is required for epithelial integrity of the zebrafish epidermis. Carney TJ, et al. Development, 2007 Oct. PMID 17728346
  3. Met and Hgf signaling controls hypaxial muscle and lateral line development in the zebrafish. Haines L, et al. Development, 2004 Oct. PMID 15342468
  4. Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation. Karampelias C, et al. Nat Commun, 2021 Jun 7. PMID 34099692, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in epidermis development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within epidermis development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in epithelium development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kunitz-type protease inhibitor 1b
Names
hai1b
hepatocyte growth factor activator inhibitor 1
hepatocyte growth factor activator inhibitor 1b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111223.1 → NP_001104693.1  kunitz-type protease inhibitor 1b precursor

    See identical proteins and their annotated locations for NP_001104693.1

    Status: PROVISIONAL

    Source sequence(s)
    BC155551
    UniProtKB/TrEMBL
    A9JR82
    Related
    ENSDARP00000006108.7, ENSDART00000008077.9
    Conserved Domains (4) summary
    smart00089
    Location:148 → 225
    PKD; Repeats in polycystic kidney disease 1 (PKD1) and other proteins
    cd00112
    Location:308 → 342
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00014
    Location:363 → 413
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam07502
    Location:31 → 116
    MANEC; MANEC domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    3218893..3238079 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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