acd ACD shelterin complex subunit and telomerase recruitment factor [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: acdprovided by ZNC
Official Full Name: ACD shelterin complex subunit and telomerase recruitment factorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-081022-45
See related: Ensembl:ENSDARG00000078055 AllianceGenome:ZFIN:ZDB-GENE-081022-45
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: tpp1; zgc:193816
Summary: Enables telomeric DNA binding activity. Acts upstream of or within heart development and negative regulation of apoptotic process. Predicted to be located in chromosome, telomeric region and nucleus. Predicted to be part of shelterin complex. Human ortholog(s) of this gene implicated in autosomal dominant dyskeratosis congenita 6. Orthologous to human ACD (ACD shelterin complex subunit and telomerase recruitment factor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 7

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (29080642..29094304)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (28809497..28823023)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

this work shows that the shelterin subunits exhibit distinct spatiotemporal expression patterns, suggesting important tissue-specific functions during development and aging
Title: Progressive changes in non-coding RNA profile in leucocytes with age.
Knocking down TPP1 led to multiple abnormalities in zebrafish embryogenesis, including neural death, heart malformation, and caudal defect.
Title: Zebrafish as a model system to study the physiological function of telomeric protein TPP1.

Submit: New GeneRIF Correction

General gene information

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Markers

fb18c01.x1 (e-PCR)
- UniSTS:190235

fi17h12.x1 (e-PCR)
- UniSTS:196945

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables telomeric DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables telomeric DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables telomeric DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of telomere maintenance via telomerase	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of telomerase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to chromosome, telomeric region	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomere capping	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within telomere capping	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within telomere maintenance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within telomere maintenance via telomerase	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
part_of nuclear telomere cap complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of shelterin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of shelterin complex	IEA Inferred from Electronic Annotation more info
part_of telomerase holoenzyme complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: adrenocortical dysplasia protein homolog; telomeric protein TPP1

Names: adrenocortical dysplasia homolog; zfTPP1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130793.1 → NP_001124265.1 adrenocortical dysplasia protein homolog

See identical proteins and their annotated locations for NP_001124265.1

Status: PROVISIONAL

Source sequence(s)

BC162572

UniProtKB/TrEMBL

B3DGY9

Related

ENSDARP00000142667.1, ENSDART00000173709.2

Conserved Domains (1) summary

pfam10341
Location:6 → 110

TPP1; Shelterin complex subunit, TPP1/ACD

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

29080642..29094304

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005168914.4 → XP_005168971.1 telomeric protein TPP1 isoform X1

UniProtKB/TrEMBL

A0A1D5NT19, A0A8M2BG65

Related

ENSDARP00000142991.1, ENSDART00000173576.2

Conserved Domains (1) summary

pfam10341
Location:16 → 120

TPP1; Shelterin complex subunit, TPP1/ACD