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Osbpl5 oxysterol binding protein-like 5 [ Mus musculus (house mouse) ]

Gene ID: 79196, updated on 11-Apr-2024

Summary

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Official Symbol
Osbpl5provided by MGI
Official Full Name
oxysterol binding protein-like 5provided by MGI
Primary source
MGI:MGI:1930265
See related
Ensembl:ENSMUSG00000037606 AllianceGenome:MGI:1930265
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ORP5; Obph1; Osbp2; 1110006M06Rik
Summary
Predicted to enable several functions, including cholesterol binding activity; phosphatidylserine transfer activity; and phospholipid binding activity. Predicted to be involved in phospholipid transport. Predicted to act upstream of or within lipid transport. Predicted to be located in endoplasmic reticulum-plasma membrane contact site. Predicted to be active in cytosol; intracellular membrane-bounded organelle; and membrane. Is expressed in several structures, including central nervous system; extraembryonic component; genitourinary system; immune system; and notochord. Orthologous to human OSBPL5 (oxysterol binding protein like 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 27.8), ovary adult (RPKM 26.8) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 F5; 7 88.29 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (143242499..143310745, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (143688762..143757008, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E230032D23 gene Neighboring gene STARR-seq mESC enhancer starr_20534 Neighboring gene tumor necrosis factor receptor superfamily, member 22 Neighboring gene tumor necrosis factor receptor superfamily, member 23 Neighboring gene STARR-positive B cell enhancer ABC_E10486 Neighboring gene STARR-positive B cell enhancer ABC_E2256 Neighboring gene STARR-positive B cell enhancer ABC_E3762 Neighboring gene MAS-related GPR, member G Neighboring gene MAS-related GPR, member E

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization and imprinting status of OBPH1/Obph1 gene: implications for an extended imprinting domain in human and mouse. Higashimoto K, et al. Genomics, 2002 Dec. PMID 12504849
  2. Oxysterol binding protein induces upregulation of SREBP-1c and enhances hepatic lipogenesis. Yan D, et al. Arterioscler Thromb Vasc Biol, 2007 May. PMID 17303778
  3. The Tnfrh1 (Tnfrsf23) gene is weakly imprinted in several organs and expressed at the trophoblast-decidua interface. Clark L, et al. BMC Genet, 2002 Jun 27. PMID 12102730, Free PMC Article
  4. Identification of a new murine tumor necrosis factor receptor locus that contains two novel murine receptors for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Schneider P, et al. J Biol Chem, 2003 Feb 14. PMID 12466268
  5. Family of human oxysterol binding protein (OSBP) homologues. A novel member implicated in brain sterol metabolism. Laitinen S, et al. J Lipid Res, 1999 Dec. PMID 10588946

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. OBPH1/Obph1 gene is imprinted, with preferential expression from the maternal allele in human and mouse.
    Title: Characterization and imprinting status of OBPH1/Obph1 gene: implications for an extended imprinting domain in human and mouse.
  2. OSBP regulates hepatic TG metabolism and suggest the involvement of OSBP in the insulin signaling pathways that control hepatic lipogenesis.
    Title: Oxysterol binding protein induces upregulation of SREBP-1c and enhances hepatic lipogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cholesterol binding ISO
Inferred from Sequence Orthology
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-4-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylserine binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylserine transfer activity ISO
Inferred from Sequence Orthology
more info
  
enables sterol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum-plasma membrane contact site ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
oxysterol-binding protein-related protein 5
Names
ORP-5
OSBP-related protein 5
oxysterol binding protein 2
oxysterol binding protein homolog 1
oxysterol-binding protein-like protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199227.1 → NP_001186156.1  oxysterol-binding protein-related protein 5 isoform 2

    See identical proteins and their annotated locations for NP_001186156.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has a different exon at its 5' terminus which results in the use of a downstream in-frame translation initiation site, compared to variant 1. It encodes an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    BC079872, BY234441, EH108768
    Consensus CDS
    CCDS57598.1
    UniProtKB/Swiss-Prot
    Q8R510, Q99NF5, Q9ER64
    Related
    ENSMUSP00000113362.2, ENSMUST00000119499.8
    Conserved Domains (3) summary
    cd13286
    Location:120 → 248
    PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
    pfam00169
    Location:127 → 243
    PH; PH domain
    pfam01237
    Location:373 → 706
    Oxysterol_BP; Oxysterol-binding protein

  2. NM_001384163.1 → NP_001371092.1  oxysterol-binding protein-related protein 5 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 3, which encodes a shorter protein compared to isoform 1.
    Source sequence(s)
    AC068006, AC158299
    Conserved Domains (2) summary
    cd13286
    Location:132 → 260
    PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
    pfam01237
    Location:385 → 721
    Oxysterol_BP; Oxysterol-binding protein

  3. NM_024289.2 → NP_077251.1  oxysterol-binding protein-related protein 5 isoform 1

    See identical proteins and their annotated locations for NP_077251.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC068006, AC158299
    Consensus CDS
    CCDS40200.1
    UniProtKB/TrEMBL
    G5E833
    Related
    ENSMUSP00000020411.8, ENSMUST00000020411.14
    Conserved Domains (3) summary
    cd13286
    Location:144 → 272
    PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
    pfam00169
    Location:151 → 267
    PH; PH domain
    pfam01237
    Location:397 → 730
    Oxysterol_BP; Oxysterol-binding protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    143242499..143310745 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508659.4 → XP_006508722.1  oxysterol-binding protein-related protein 5 isoform X2

    Conserved Domains (2) summary
    cd13286
    Location:72 → 200
    PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
    pfam01237
    Location:325 → 661
    Oxysterol_BP; Oxysterol-binding protein

  2. XM_011242024.1 → XP_011240326.1  oxysterol-binding protein-related protein 5 isoform X1

    Conserved Domains (2) summary
    cd13286
    Location:120 → 248
    PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
    pfam01237
    Location:373 → 676
    Oxysterol_BP; Oxysterol-binding protein

RNA

  1. XR_001778018.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ER64.3 GenPept UniProtKB/Swiss-Prot:Q9ER64

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