U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MFSD11 major facilitator superfamily domain containing 11 [ Homo sapiens (human) ]

Gene ID: 79157, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
MFSD11provided by HGNC
Official Full Name
major facilitator superfamily domain containing 11provided by HGNC
Primary source
HGNC:HGNC:25458
See related
Ensembl:ENSG00000092931 MIM:620346; AllianceGenome:HGNC:25458
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ET
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon (RPKM 5.3), stomach (RPKM 4.4) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
17q25.1-q25.2
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (76736634..76803805)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (77633621..77695809)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (74732716..74775423)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74722561-74723190 Neighboring gene jumonji domain containing 6, arginine demethylase and lysine hydroxylase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74723821-74724449 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74725107-74725737 Neighboring gene methyltransferase 23, arginine Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74732487-74733112 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12814 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:74736456-74736653 Neighboring gene serine and arginine rich splicing factor 2 Neighboring gene microRNA 636 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74751679-74752180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74752181-74752680 Neighboring gene RNA, U6 small nuclear 97, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:74800558-74801081 Neighboring gene long intergenic non-protein coding RNA 2080 Neighboring gene MPRA-validated peak3011 silencer Neighboring gene uncharacterized LOC107985089 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74822016-74822832 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74834234-74834958 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12815 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:74835690-74835885 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12816 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12817 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74837373-74837889 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74840421-74841249 Neighboring gene long intergenic non-protein coding RNA 868

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Characterization of multiple alternative RNAs resulting from antisense transcription of the PR264/SC35 splicing factor gene. Sureau A, et al. Nucleic Acids Res, 1997 Nov 15. PMID 9358160, Free PMC Article
  2. Genetic loci for retinal arteriolar microcirculation. Sim X, et al. PLoS One, 2013. PMID 23776548, Free PMC Article
  3. The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis. Perland E, et al. PLoS One, 2016. PMID 27272503, Free PMC Article
  4. The Fly Homologue of MFSD11 Is Possibly Linked to Nutrient Homeostasis and Has a Potential Role in Locomotion: A First Characterization of the Atypical Solute Carrier CG18549 in Drosophila Melanogaster. Ceder MM, et al. Insects, 2021 Nov 13. PMID 34821824, Free PMC Article
  5. Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development. Hasegawa Y, et al. PLoS Genet, 2015 Aug. PMID 26288249, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic loci for retinal arteriolar microcirculation.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ20226, FLJ22196

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
UNC93-like protein MFSD11
Names
major facilitator superfamily domain-containing protein 11
protein ET

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242532.5 → NP_001229461.1  UNC93-like protein MFSD11 isoform 1

    See identical proteins and their annotated locations for NP_001229461.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1-5 and 8-10 encode the same protein (isoform 1).
    Source sequence(s)
    AC005837, AC027694
    Consensus CDS
    CCDS11750.1
    UniProtKB/Swiss-Prot
    O43442, O43934, Q9NXI5
    Related
    ENSP00000508960.1, ENST00000685175.1
    Conserved Domains (1) summary
    pfam05978
    Location:14 → 166
    UNC-93; Ion channel regulatory protein UNC-93

  2. NM_001242533.3 → NP_001229462.1  UNC93-like protein MFSD11 isoform 1

    See identical proteins and their annotated locations for NP_001229462.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1-5 and 8-10 encode the same protein (isoform 1).
    Source sequence(s)
    AC005837, AC027694
    Consensus CDS
    CCDS11750.1
    UniProtKB/Swiss-Prot
    O43442, O43934, Q9NXI5
    Related
    ENSP00000468309.1, ENST00000590514.5
    Conserved Domains (1) summary
    pfam05978
    Location:14 → 166
    UNC-93; Ion channel regulatory protein UNC-93

  3. NM_001242534.3 → NP_001229463.1  UNC93-like protein MFSD11 isoform 1

    See identical proteins and their annotated locations for NP_001229463.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1-5 and 8-10 encode the same protein (isoform 1).
    Source sequence(s)
    AC005837, AC027694
    Consensus CDS
    CCDS11750.1
    UniProtKB/Swiss-Prot
    O43442, O43934, Q9NXI5
    Related
    ENSP00000485005.1, ENST00000621483.4
    Conserved Domains (1) summary
    pfam05978
    Location:14 → 166
    UNC-93; Ion channel regulatory protein UNC-93

  4. NM_001242535.3 → NP_001229464.1  UNC93-like protein MFSD11 isoform 1

    See identical proteins and their annotated locations for NP_001229464.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1-5 and 8-10 encode the same protein (isoform 1).
    Source sequence(s)
    AC005837, AC027694
    Consensus CDS
    CCDS11750.1
    UniProtKB/Swiss-Prot
    O43442, O43934, Q9NXI5
    Conserved Domains (1) summary
    pfam05978
    Location:14 → 166
    UNC-93; Ion channel regulatory protein UNC-93

  5. NM_001242536.3 → NP_001229465.1  UNC93-like protein MFSD11 isoform 2

    See identical proteins and their annotated locations for NP_001229465.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and lacks two in-frame exons in the 5' coding region, compared to variant 1. This variant encodes a shorter protein (isoform 2), compared to isoform 1. Variants 6 and 7 encode the same protein (isoform 2).
    Source sequence(s)
    AC005837, AC027694
    Consensus CDS
    CCDS56045.1
    Related
    ENSP00000348225.3, ENST00000355954.7
    Conserved Domains (1) summary
    cl21472
    Location:14 → 113
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

  6. NM_001242537.3 → NP_001229466.1  UNC93-like protein MFSD11 isoform 2

    See identical proteins and their annotated locations for NP_001229466.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and lacks two in-frame exons in the 5' coding region, compared to variant 1. This variant encodes a shorter protein (isoform 2), compared to isoform 1. Variants 6 and 7 encode the same protein (isoform 2).
    Source sequence(s)
    AC005837, AC027694
    Consensus CDS
    CCDS56045.1
    Related
    ENSP00000466782.1, ENST00000593181.5
    Conserved Domains (1) summary
    cl21472
    Location:14 → 113
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

  7. NM_001353017.2 → NP_001339946.1  UNC93-like protein MFSD11 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1-5 and 8-10 encode the same protein (isoform 1).
    Source sequence(s)
    AC005837, AC027694
    Consensus CDS
    CCDS11750.1
    UniProtKB/Swiss-Prot
    O43442, O43934, Q9NXI5
    Conserved Domains (1) summary
    pfam05978
    Location:14 → 166
    UNC-93; Ion channel regulatory protein UNC-93

  8. NM_001353018.2 → NP_001339947.1  UNC93-like protein MFSD11 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1-5 and 8-10 encode the same protein (isoform 1).
    Source sequence(s)
    AC005837, AC027694
    Consensus CDS
    CCDS11750.1
    UniProtKB/Swiss-Prot
    O43442, O43934, Q9NXI5
    Conserved Domains (1) summary
    pfam05978
    Location:14 → 166
    UNC-93; Ion channel regulatory protein UNC-93

  9. NM_001353019.2 → NP_001339948.1  UNC93-like protein MFSD11 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1-5 and 8-10 encode the same protein (isoform 1).
    Source sequence(s)
    AC005837, AC027694
    Consensus CDS
    CCDS11750.1
    UniProtKB/Swiss-Prot
    O43442, O43934, Q9NXI5
    Conserved Domains (1) summary
    pfam05978
    Location:14 → 166
    UNC-93; Ion channel regulatory protein UNC-93

  10. NM_024311.5 → NP_077287.1  UNC93-like protein MFSD11 isoform 1

    See identical proteins and their annotated locations for NP_077287.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1-5 and 8-10 encode the same protein (isoform 1).
    Source sequence(s)
    AC005837, AC027694
    Consensus CDS
    CCDS11750.1
    UniProtKB/Swiss-Prot
    O43442, O43934, Q9NXI5
    Related
    ENSP00000337240.3, ENST00000336509.8
    Conserved Domains (1) summary
    pfam05978
    Location:14 → 166
    UNC-93; Ion channel regulatory protein UNC-93

RNA

  1. NR_148229.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005837, AC027694

  2. NR_148230.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005837, AC027694

  3. NR_148231.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005837, AC027694

  4. NR_148232.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005837, AC027694

  5. NR_148233.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005837, AC027694

  6. NR_148234.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005837, AC027694

  7. NR_148235.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005837, AC027694

  8. NR_148236.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005837, AC027694

  9. NR_148237.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (19) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005837, AC027694

  10. NR_148238.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (20) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005837, AC027694

  11. NR_148239.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (21) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005837, AC027694

  12. NR_148240.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (22) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005837, AC027694

  13. NR_148242.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (23) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005837, AC027694

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    76736634..76803805
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047436733.1 → XP_047292689.1  UNC93-like protein MFSD11 isoform X1

  2. XM_011525239.4 → XP_011523541.2  UNC93-like protein MFSD11 isoform X1

    Conserved Domains (1) summary
    pfam05978
    Location:14 → 166
    UNC-93; Ion channel regulatory protein UNC-93

  3. XM_017025065.3 → XP_016880554.1  UNC93-like protein MFSD11 isoform X1

    Conserved Domains (1) summary
    pfam05978
    Location:14 → 166
    UNC-93; Ion channel regulatory protein UNC-93

  4. XM_011525241.4 → XP_011523543.2  UNC93-like protein MFSD11 isoform X1

    Conserved Domains (1) summary
    pfam05978
    Location:14 → 166
    UNC-93; Ion channel regulatory protein UNC-93

  5. XM_011525238.4 → XP_011523540.2  UNC93-like protein MFSD11 isoform X1

    Conserved Domains (1) summary
    pfam05978
    Location:14 → 166
    UNC-93; Ion channel regulatory protein UNC-93

  6. XM_047436736.1 → XP_047292692.1  UNC93-like protein MFSD11 isoform X3

  7. XM_047436737.1 → XP_047292693.1  UNC93-like protein MFSD11 isoform X5

  8. XM_011525237.4 → XP_011523539.2  UNC93-like protein MFSD11 isoform X1

    Conserved Domains (1) summary
    pfam05978
    Location:14 → 166
    UNC-93; Ion channel regulatory protein UNC-93

  9. XM_047436735.1 → XP_047292691.1  UNC93-like protein MFSD11 isoform X2

  10. XM_011525247.3 → XP_011523549.2  UNC93-like protein MFSD11 isoform X4

  11. XM_047436738.1 → XP_047292694.1  UNC93-like protein MFSD11 isoform X6

  12. XM_047436739.1 → XP_047292695.1  UNC93-like protein MFSD11 isoform X7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    77633621..77695809
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054317188.1 → XP_054173163.1  UNC93-like protein MFSD11 isoform X1

  2. XM_054317195.1 → XP_054173170.1  UNC93-like protein MFSD11 isoform X8

    UniProtKB/Swiss-Prot
    O43442, O43934, Q9NXI5

  3. XM_054317192.1 → XP_054173167.1  UNC93-like protein MFSD11 isoform X1

  4. XM_054317191.1 → XP_054173166.1  UNC93-like protein MFSD11 isoform X1

  5. XM_054317189.1 → XP_054173164.1  UNC93-like protein MFSD11 isoform X1

  6. XM_054317193.1 → XP_054173168.1  UNC93-like protein MFSD11 isoform X1

  7. XM_054317190.1 → XP_054173165.1  UNC93-like protein MFSD11 isoform X1

  8. XM_054317196.1 → XP_054173171.1  UNC93-like protein MFSD11 isoform X3

  9. XM_054317198.1 → XP_054173173.1  UNC93-like protein MFSD11 isoform X5

  10. XM_054317187.1 → XP_054173162.1  UNC93-like protein MFSD11 isoform X1

  11. XM_054317194.1 → XP_054173169.1  UNC93-like protein MFSD11 isoform X2

  12. XM_054317197.1 → XP_054173172.1  UNC93-like protein MFSD11 isoform X4

  13. XM_054317199.1 → XP_054173174.1  UNC93-like protein MFSD11 isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O43934.2 GenPept UniProtKB/Swiss-Prot:O43934

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous