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METTL16 methyltransferase 16, RNA N6-adenosine [ Homo sapiens (human) ]

Gene ID: 79066, updated on 11-Apr-2024

Summary

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Official Symbol
METTL16provided by HGNC
Official Full Name
methyltransferase 16, RNA N6-adenosineprovided by HGNC
Primary source
HGNC:HGNC:28484
See related
Ensembl:ENSG00000127804 AllianceGenome:HGNC:28484
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
METT10D
Summary
Enables RNA binding activity and RNA methyltransferase activity. Involved in RNA modification and regulation of mRNA metabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 7.5), thyroid (RPKM 6.7) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
17p13.3
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (2415715..2511888, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (2304395..2400696, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (2319343..2415182, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:2289277-2290101 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:2291629-2292130 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:2296137-2296704 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:2296705-2297271 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7998 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2301897-2302468 Neighboring gene hESC enhancers GRCh37_chr17:2302469-2303038 and GRCh37_chr17:2303039-2303609 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8001 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8000 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8002 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11493 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2305321-2305891 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:2305892-2306461 Neighboring gene MAX network transcriptional repressor Neighboring gene uncharacterized LOC284009 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2337127-2337806 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2337807-2338485 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2338486-2339164 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2339165-2339843 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:2383040-2383219 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11494 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:2398718-2399218 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:2403917-2404418 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:2404419-2404918 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2409238-2410149 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2410150-2411060 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11495 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11496 Neighboring gene MPRA-validated peak2683 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:2453840-2454586 Neighboring gene RNA, 7SL, cytoplasmic 33, pseudogene Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. METTL16 promotes glycolytic metabolism reprogramming and colorectal cancer progression. Wei W, et al. J Exp Clin Cancer Res, 2023 Jun 20. PMID 37340443, Free PMC Article
  2. METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism. Han L, et al. Cell Stem Cell, 2023 Jan 5. PMID 36608679, Free PMC Article
  3. Elucidating the Kinetic Mechanism of Human METTL16. Breger K, et al. Biochemistry, 2023 Jan 17. PMID 36584291, Free PMC Article
  4. Clinical Significance of Methyltransferase-like 16 Expression in Epithelial Ovarian Cancer. Li C, et al. J Coll Physicians Surg Pak, 2022 Dec. PMID 36474378
  5. METTL16 epigenetically enhances GPX4 expression via m6A modification to promote breast cancer progression by inhibiting ferroptosis. Ye F, et al. Biochem Biophys Res Commun, 2023 Jan 1. PMID 36434904

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. METTL16 promotes osteosarcoma progression by downregulating VPS33B in an m[6] A-dependent manner.
    Title: METTL16 promotes osteosarcoma progression by downregulating VPS33B in an m(6) A-dependent manner.
  2. METTL16 suppressed the proliferation and cisplatin-chemoresistance of bladder cancer by degrading PMEPA1 mRNA in a m6A manner through autophagy pathway.
    Title: METTL16 suppressed the proliferation and cisplatin-chemoresistance of bladder cancer by degrading PMEPA1 mRNA in a m6A manner through autophagy pathway.
  3. Targeting key RNA methylation enzymes to improve the outcome of colorectal cancer chemotherapy (Review).
    Title: Targeting key RNA methylation enzymes to improve the outcome of colorectal cancer chemotherapy (Review).
  4. METTL16 inhibits papillary thyroid cancer tumorigenicity through m[6]A/YTHDC2/SCD1-regulated lipid metabolism.
    Title: METTL16 inhibits papillary thyroid cancer tumorigenicity through m(6)A/YTHDC2/SCD1-regulated lipid metabolism.
  5. METTL16 promotes liver cancer stem cell self-renewal via controlling ribosome biogenesis and mRNA translation.
    Title: METTL16 promotes liver cancer stem cell self-renewal via controlling ribosome biogenesis and mRNA translation.
  6. METTL16 Inhibits the Malignant Progression of Epithelial Ovarian Cancer through the lncRNA MALAT1/beta-Catenin Axis.
    Title: METTL16 Inhibits the Malignant Progression of Epithelial Ovarian Cancer through the lncRNA MALAT1/β-Catenin Axis.
  7. The RNA methyltransferase METTL16 enhances cholangiocarcinoma growth through PRDM15-mediated FGFR4 expression.
    Title: The RNA methyltransferase METTL16 enhances cholangiocarcinoma growth through PRDM15-mediated FGFR4 expression.
  8. Functional analysis of 3'-UTR hairpins supports a two-tiered model for posttranscriptional regulation of MAT2A by METTL16.
    Title: Functional analysis of 3'-UTR hairpins supports a two-tiered model for posttranscriptional regulation of MAT2A by METTL16.
  9. METTL16 controls Kaposi's sarcoma-associated herpesvirus replication by regulating S-adenosylmethionine cycle.
    Title: METTL16 controls Kaposi's sarcoma-associated herpesvirus replication by regulating S-adenosylmethionine cycle.
  10. Genetic Variations Within METTL16 and Susceptibility to Sudden Cardiac Death in Chinese Populations With Coronary Artery Disease.
    Title: Genetic Variations Within METTL16 and Susceptibility to Sudden Cardiac Death in Chinese Populations With Coronary Artery Disease.
Submit: New GeneRIF Correction See all GeneRIFs (35)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC3329

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 23S rRNA (adenine(1618)-N(6))-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding HDA PubMed 
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA stem-loop binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables U6 snRNA (adenine-(43)-N(6))-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables U6 snRNA 3'-end binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA m(6)A methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of S-adenosylmethionine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of S-adenosylmethionine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mRNA destabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mRNA modification IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of 3'-UTR-mediated mRNA stabilization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in post-transcriptional regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in rRNA base methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in snRNA (adenine-N6)-methylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
RNA N6-adenosine-methyltransferase METTL16
Names
N6-adenosine-methyltransferase METTL16
N6-methyladenosine methyltransferase
U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase
U6 snRNA methyltransferase
methyltransferase 10 domain containing
methyltransferase 10 domain-containing protein
methyltransferase 16, N6-methyladenosine
methyltransferase like 16
methyltransferase-like protein 16
putative methyltransferase METT10D
NP_076991.3
XP_024306696.1
XP_047292653.1
XP_047292654.1
XP_054173101.1
XP_054173102.1
XP_054173103.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024086.4 → NP_076991.3  RNA N6-adenosine-methyltransferase METTL16

    See identical proteins and their annotated locations for NP_076991.3

    Status: VALIDATED

    Source sequence(s)
    AC006435, BC050603, DB227557
    Consensus CDS
    CCDS42232.1
    UniProtKB/Swiss-Prot
    D3DTI8, Q86TE5, Q86W50, Q96T16, Q9BVG7
    Related
    ENSP00000263092.5, ENST00000263092.11
    Conserved Domains (1) summary
    pfam05971
    Location:40 → 291
    Methyltransf_10; Protein of unknown function (DUF890)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    2415715..2511888 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047436697.1 → XP_047292653.1  RNA N6-adenosine-methyltransferase METTL16 isoform X1

    Related
    ENST00000571669.6

  2. XM_047436698.1 → XP_047292654.1  RNA N6-adenosine-methyltransferase METTL16 isoform X2

    UniProtKB/TrEMBL
    B7Z3X7

  3. XM_024450928.2 → XP_024306696.1  RNA N6-adenosine-methyltransferase METTL16 isoform X2

    UniProtKB/TrEMBL
    B7Z3X7
    Conserved Domains (2) summary
    pfam02063
    Location:189 → 284
    MARCKS; MARCKS family
    cl17173
    Location:1 → 73
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RNA

  1. XR_007065448.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    2304395..2400696 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054317126.1 → XP_054173101.1  RNA N6-adenosine-methyltransferase METTL16 isoform X1

  2. XM_054317127.1 → XP_054173102.1  RNA N6-adenosine-methyltransferase METTL16 isoform X2

    UniProtKB/TrEMBL
    B7Z3X7

  3. XM_054317128.1 → XP_054173103.1  RNA N6-adenosine-methyltransferase METTL16 isoform X2

    UniProtKB/TrEMBL
    B7Z3X7

RNA

  1. XR_008484933.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86W50.2 GenPept UniProtKB/Swiss-Prot:Q86W50

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