Aacs acetoacetyl-CoA synthetase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aacsprovided by MGI
Official Full Name: acetoacetyl-CoA synthetaseprovided by MGI
Primary source: MGI:MGI:1926144
See related: Ensembl:ENSMUSG00000029482 AllianceGenome:MGI:1926144
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SUR5; 2210408B16Rik
Summary: Predicted to enable acetoacetate-CoA ligase activity and butyrate-CoA ligase activity. Predicted to be involved in several processes, including cellular response to glucose stimulus; positive regulation of insulin secretion; and response to oleic acid. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in alimentary system; eye; hemolymphoid system; nervous system; and urinary system. Orthologous to human AACS (acetoacetyl-CoA synthetase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in mammary gland adult (RPKM 107.7), subcutaneous fat pad adult (RPKM 90.4) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G1.1; 5 64.24 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (125552937..125594469)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (125475873..125517405)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that Sp1 regulates gene expression of AACS in Neuro-2a cells and ketone body utilization affects the balance of histone acetylation.
Title: Transcriptional regulation of acetoacetyl-CoA synthetase by Sp1 in neuroblastoma cells.
Cleavage of AACS by legumain is critical for the regulation of enzymatic activity and results in gain-of-function changes.
Title: Site-specific cleavage of acetoacetyl-CoA synthetase by legumain.
Knockdown of AACS inhibits differentiation of 3T3-L1 adipocytes and suppresses expression of the adipocyte markers, peroxisome proliferator-activated receptor gama and CCAAT/enhancer binding protein alpha.
Title: The role of acetoacetyl-CoA synthetase, a ketone body-utilizing enzyme, in 3T3-L1 adipocyte differentiation.
Acetoacetyl-CoA synthetase, a ketone body-utilizing enzyme, is controlled by SREBP-2 and affects serum cholesterol levels.
Title: Acetoacetyl-CoA synthetase, a ketone body-utilizing enzyme, is controlled by SREBP-2 and affects serum cholesterol levels.
These results suggest that AACS is regulated by SREBP-2 and involves in the normal development of neurons.
Title: Acetoacetyl-CoA synthetase is essential for normal neuronal development.
AACS promoter activity was controlled mainly by C/EBPalpha during adipogenesis.
Title: Transcriptional regulation of ketone body-utilizing enzyme, acetoacetyl-CoA synthetase, by C/EBPalpha during adipocyte differentiation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables acetoacetate-CoA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetoacetate-CoA ligase activity	ISO Inferred from Sequence Orthology more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables medium-chain fatty acid-CoA ligase activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in liver development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	ISO Inferred from Sequence Orthology more info
involved_in response to nutrient	ISO Inferred from Sequence Orthology more info
involved_in response to oleic acid	ISO Inferred from Sequence Orthology more info
involved_in response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
involved_in response to organonitrogen compound	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: acetoacetyl-CoA synthetase

NP_084486.1

EC 6.2.1.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030210.2 → NP_084486.1 acetoacetyl-CoA synthetase

See identical proteins and their annotated locations for NP_084486.1

Status: VALIDATED

Source sequence(s)

AC119268

Consensus CDS

CCDS19687.1

UniProtKB/Swiss-Prot

A1IG47, Q3TCL8, Q3UD39, Q9D2R0

Related

ENSMUSP00000031445.4, ENSMUST00000031445.5

Conserved Domains (2) summary

cd05943
Location:40 → 663

AACS; Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS)

TIGR01217
Location:16 → 671

ac_ac_CoA_syn; acetoacetyl-CoA synthase