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Usp54 ubiquitin specific peptidase 54 [ Mus musculus (house mouse) ]

Gene ID: 78787, updated on 9-May-2024

Summary

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Official Symbol
Usp54provided by MGI
Official Full Name
ubiquitin specific peptidase 54provided by MGI
Primary source
MGI:MGI:1926037
See related
Ensembl:ENSMUSG00000034235 AllianceGenome:MGI:1926037
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930429G18Rik; C030002J06Rik
Summary
Predicted to enable thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination. Orthologous to human USP54 (ubiquitin specific peptidase 54). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 6.3), cortex adult (RPKM 4.8) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 A3; 14 11.53 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (20598980..20694559, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (20548912..20644491, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene MSS51 mitochondrial translational activator Neighboring gene STARR-seq mESC enhancer starr_36112 Neighboring gene protein phosphatase 3, catalytic subunit, beta isoform Neighboring gene RIKEN cDNA 1810062O18 gene Neighboring gene STARR-positive B cell enhancer ABC_E11565 Neighboring gene STARR-positive B cell enhancer ABC_E7297 Neighboring gene myozenin 1 Neighboring gene synaptopodin 2-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The deubiquitinase USP54 is overexpressed in colorectal cancer stem cells and promotes intestinal tumorigenesis. Fraile JM, et al. Oncotarget, 2016 Nov 15. PMID 27769071, Free PMC Article
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in protein deubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
inactive ubiquitin carboxyl-terminal hydrolase 54
Names
inactive ubiquitin-specific peptidase 54
ubiquitin specific protease 54

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403077.1 → NP_001390006.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC146594

  2. NM_001403078.1 → NP_001390007.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC146594
    UniProtKB/Swiss-Prot
    Q149D8, Q149D9, Q6NZE1, Q8BL06, Q8BZ28, Q9D2I9
    Related
    ENSMUSP00000022356.5, ENSMUST00000022356.12

  3. NM_001403079.1 → NP_001390008.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC146594

  4. NM_001403080.1 → NP_001390009.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC146594

  5. NM_001403081.1 → NP_001390010.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC146594

  6. NM_030180.3 → NP_084456.2  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 1

    See identical proteins and their annotated locations for NP_084456.2

    Status: VALIDATED

    Source sequence(s)
    AC146594
    Consensus CDS
    CCDS26847.2
    UniProtKB/Swiss-Prot
    Q149D8, Q149D9, Q6NZE1, Q8BL06, Q8BZ28, Q9D2I9
    Related
    ENSMUSP00000036214.8, ENSMUST00000035340.14
    Conserved Domains (1) summary
    pfam00443
    Location:32 → 349
    UCH; Ubiquitin carboxyl-terminal hydrolase

RNA

  1. NR_175348.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC146594

  2. NR_175349.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC146594

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    20598980..20694559 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158911.1 → XP_036014804.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform X3

    Conserved Domains (1) summary
    pfam00443
    Location:32 → 349
    UCH; Ubiquitin carboxyl-terminal hydrolase

  2. XM_036158913.1 → XP_036014806.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform X6

    Conserved Domains (1) summary
    pfam00443
    Location:32 → 349
    UCH; Ubiquitin carboxyl-terminal hydrolase

  3. XM_036158908.1 → XP_036014801.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform X1

    Conserved Domains (1) summary
    pfam00443
    Location:32 → 349
    UCH; Ubiquitin carboxyl-terminal hydrolase

  4. XM_036158915.1 → XP_036014808.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform X9

  5. XM_036158910.1 → XP_036014803.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform X1

    Conserved Domains (1) summary
    pfam00443
    Location:32 → 349
    UCH; Ubiquitin carboxyl-terminal hydrolase

  6. XM_036158909.1 → XP_036014802.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform X1

    Conserved Domains (1) summary
    pfam00443
    Location:32 → 349
    UCH; Ubiquitin carboxyl-terminal hydrolase

  7. XM_036158912.1 → XP_036014805.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform X5

    Conserved Domains (1) summary
    cd02257
    Location:12 → 220
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

RNA

  1. XR_001781171.2 RNA Sequence

  2. XR_001781170.2 RNA Sequence

  3. XR_004938462.1 RNA Sequence

  4. XR_004938461.1 RNA Sequence

  5. XR_001781172.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BL06.2 GenPept UniProtKB/Swiss-Prot:Q8BL06

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