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Lipm lipase, family member M [ Mus musculus (house mouse) ]

Gene ID: 78753, updated on 8-Feb-2024

Summary

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Official Symbol
Lipmprovided by MGI
Official Full Name
lipase, family member Mprovided by MGI
Primary source
MGI:MGI:1926003
See related
Ensembl:ENSMUSG00000056078 AllianceGenome:MGI:1926003
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lipl3; 4632427C23Rik
Summary
Predicted to enable hydrolase activity, acting on ester bonds. Predicted to act upstream of or within lipid catabolic process. Predicted to be located in extracellular region. Is expressed in anterior naris and external naris. Orthologous to human LIPM (lipase family member M). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in limb E14.5 (RPKM 1.4), stomach adult (RPKM 0.3) and 2 other tissues See more
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Genomic context

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Location:
19 C1; 19 29.32 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (34078343..34100087)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (34100943..34122687)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31300 Neighboring gene lipase, family member N Neighboring gene STARR-seq mESC enhancer starr_45988 Neighboring gene STARR-seq mESC enhancer starr_45989 Neighboring gene ankyrin repeat domain 22 Neighboring gene STARR-seq mESC enhancer starr_45990 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:34255778-34255996 Neighboring gene STARR-positive B cell enhancer ABC_E5696 Neighboring gene STAM binding protein like 1 Neighboring gene STARR-seq mESC enhancer starr_45992 Neighboring gene actin alpha 2, smooth muscle, aorta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lipase member M
Names
lipase-like abhydrolase domain-containing protein 3
lipase-like, ab-hydrolase domain containing 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023903.1 → NP_076392.1  lipase member M precursor

    See identical proteins and their annotated locations for NP_076392.1

    Status: VALIDATED

    Source sequence(s)
    AK037091, AK085719
    Consensus CDS
    CCDS50419.1
    UniProtKB/Swiss-Prot
    Q8BJ28, Q8K2A6
    Related
    ENSMUSP00000025685.7, ENSMUST00000025685.8
    Conserved Domains (1) summary
    PLN02872
    Location:50 → 408
    PLN02872; triacylglycerol lipase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    34078343..34100087
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527466.4 → XP_006527529.1  lipase member M isoform X1

    See identical proteins and their annotated locations for XP_006527529.1

    UniProtKB/Swiss-Prot
    Q8BJ28, Q8K2A6
    Conserved Domains (1) summary
    PLN02872
    Location:50 → 408
    PLN02872; triacylglycerol lipase

  2. XM_006527467.4 → XP_006527530.1  lipase member M isoform X3

    Conserved Domains (1) summary
    PLN02872
    Location:1 → 218
    PLN02872; triacylglycerol lipase

  3. XM_017318314.2 → XP_017173803.1  lipase member M isoform X2

    Conserved Domains (1) summary
    PLN02872
    Location:27 → 237
    PLN02872; triacylglycerol lipase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K2A6.1 GenPept UniProtKB/Swiss-Prot:Q8K2A6

Gene LinkOut

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