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Zfp449 zinc finger protein 449 [ Mus musculus (house mouse) ]

Gene ID: 78619, updated on 5-Mar-2024

Summary

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Official Symbol
Zfp449provided by MGI
Official Full Name
zinc finger protein 449provided by MGI
Primary source
MGI:MGI:1925869
See related
Ensembl:ENSMUSG00000073176 AllianceGenome:MGI:1925869
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9530049C15Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within spermatogonial cell division. Is expressed in genitourinary system. Orthologous to human ZNF449 (zinc finger protein 449). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 2.2), bladder adult (RPKM 1.6) and 21 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X A5; X 30.06 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (55391757..55411034)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (56346397..56365674)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1600025M17 gene Neighboring gene predicted gene, 38625 Neighboring gene small integral membrane protein 10 like 2A Neighboring gene predicted gene 2155 Neighboring gene 40S ribosomal protein S23 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of SCAN domain zinc-finger gene ZNF449 as a novel factor of chondrogenesis. Okada K, et al. PLoS One, 2014. PMID 25546433, Free PMC Article
  2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spermatogonial cell division IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 449

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359276.1 → NP_001346205.1  zinc finger protein 449 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL683799, BC082594, CR954970, CR955029
    Conserved Domains (3) summary
    COG5048
    Location:203 → 354
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:205 → 225
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:357 → 382
    zf-H2C2_2; Zinc-finger double domain

  2. NM_030139.5 → NP_084415.1  zinc finger protein 449 isoform 1

    See identical proteins and their annotated locations for NP_084415.1

    Status: VALIDATED

    Source sequence(s)
    AK036596, AK142888, BB527216, BC082594
    Consensus CDS
    CCDS30143.1
    UniProtKB/TrEMBL
    Q8CB76
    Related
    ENSMUSP00000099096.4, ENSMUST00000101560.4
    Conserved Domains (6) summary
    smart00431
    Location:27 → 134
    SCAN; leucine rich region
    COG5048
    Location:323 → 483
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:325 → 345
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:323 → 345
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:27 → 113
    SCAN; SCAN domain
    pfam13465
    Location:421 → 446
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    55391757..55411034
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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