Ndufv3 NADH:ubiquinone oxidoreductase core subunit V3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ndufv3provided by MGI
Official Full Name: NADH:ubiquinone oxidoreductase core subunit V3provided by MGI
Primary source: MGI:MGI:1890894
See related: Ensembl:ENSMUSG00000024038 AllianceGenome:MGI:1890894
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1500032D16Rik
Summary: Predicted to be involved in mitochondrial ATP synthesis coupled electron transport. Located in mitochondrion. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Orthologous to human NDUFV3 (NADH:ubiquinone oxidoreductase subunit V3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in heart adult (RPKM 60.1), kidney adult (RPKM 42.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 16.64 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (31739089..31750300)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (31520115..31531326)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Further mass spectrometric analyses of complex I from different murine and bovine tissues showed a tissue-specific expression pattern of NDUFV3-S and NDUFV3-L. Hence, NDUFV3-S was identified as the only isoform in heart and skeletal muscle, whereas in liver, brain, and lung NDUFV3-L was expressed as the dominant isoform, together with NDUFV3-S present in all tissues analyzed
Title: Identification and evolutionary analysis of tissue-specific isoforms of mitochondrial complex I subunit NDUFV3.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129486 (e-PCR)
- UniSTS:212791

1500032D16Rik (e-PCR), detects polymorphism
- UniSTS:259016

1500032D16Rik (e-PCR), detects polymorphism
- UniSTS:259566

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in aerobic respiration	NAS Non-traceable Author Statement more info	PubMed
involved_in mitochondrial ATP synthesis coupled electron transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial ATP synthesis coupled electron transport	ISO Inferred from Sequence Orthology more info
involved_in proton motive force-driven mitochondrial ATP synthesis	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
part_of mitochondrial respiratory chain complex I	IBA Inferred from Biological aspect of Ancestor more info
part_of mitochondrial respiratory chain complex I	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in respirasome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

Names: CI-9kD; NADH dehydrogenase (ubiquinone) flavoprotein 3; NADH-ubiquinone oxidoreductase 9 kDa subunit; NADH-ubiquinone oxidoreductase flavoprotein 3; complex I-9kD

NP_001077360.1

EC 7.1.1.2

NP_084363.2

EC 7.1.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083891.1 → NP_001077360.1 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform 2

See identical proteins and their annotated locations for NP_001077360.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.

Source sequence(s)

AK077433, BU555486, BU755401

Consensus CDS

CCDS37550.1

UniProtKB/Swiss-Prot

Q8BK30

Related

ENSMUSP00000066303.9, ENSMUST00000064798.16

Conserved Domains (1) summary

pfam15880
Location:63 → 97

NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
NM_030087.2 → NP_084363.2 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform 1

See identical proteins and their annotated locations for NP_084363.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC166172, BF318157, BU555486, BU755401, BY064612

Consensus CDS

CCDS37549.1

UniProtKB/TrEMBL

Q3U422, Q91WP8

Related

ENSMUSP00000049000.9, ENSMUST00000046288.16

Conserved Domains (1) summary

pfam15880
Location:427 → 460

NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial