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Zfp687 zinc finger protein 687 [ Mus musculus (house mouse) ]

Gene ID: 78266, updated on 5-Mar-2024

Summary

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Official Symbol
Zfp687provided by MGI
Official Full Name
zinc finger protein 687provided by MGI
Primary source
MGI:MGI:1925516
See related
Ensembl:ENSMUSG00000019338 AllianceGenome:MGI:1925516
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf687; mKIAA1441; 4931408L03Rik
Summary
Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be located in cytosol and nucleoplasm. Is expressed in early conceptus; genitourinary system; and olfactory epithelium. Human ortholog(s) of this gene implicated in Paget's disease of bone. Orthologous to human ZNF687 (zinc finger protein 687). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 14.0), ovary adult (RPKM 11.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 F2.1; 3 40.74 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (94901726..94923259, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (94994674..95015948, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene selenium binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E231 Neighboring gene RIKEN cDNA B230398E01 gene Neighboring gene STARR-seq mESC enhancer starr_08361 Neighboring gene regulatory factor X, 5 (influences HLA class II expression) Neighboring gene STARR-positive B cell enhancer ABC_E652 Neighboring gene phosphatidylinositol 4-kinase beta Neighboring gene STARR-positive B cell enhancer ABC_E3449 Neighboring gene RIKEN cDNA 4930481B07 gene Neighboring gene microRNA 7013 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:94820548-94820749 Neighboring gene STARR-positive B cell enhancer ABC_E4560 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 Neighboring gene STARR-seq mESC enhancer starr_08364 Neighboring gene phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha Neighboring gene predicted gene, 24920

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor. Sánchez C, et al. Mol Cell Proteomics, 2007 May. PMID 17296600
  2. Molecular Profiling Reveals Involvement of ESCO2 in Intermediate Progenitor Cell Maintenance in the Developing Mouse Cortex. Ulmke PA, et al. Stem Cell Reports, 2021 Apr 13. PMID 33798452, Free PMC Article
  3. Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks. Latos PA, et al. Genes Dev, 2015 Dec 1. PMID 26584622, Free PMC Article
  4. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Latos PA, et al. Nat Commun, 2015 Jul 24. PMID 26206133, Free PMC Article
  5. Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation. Barnes CE, et al. Mol Omics, 2022 Jan 17. PMID 34709266, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 687

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357863.1 → NP_001344792.1  zinc finger protein 687

    Status: VALIDATED

    Source sequence(s)
    AC087062
    Consensus CDS
    CCDS17600.1
    UniProtKB/Swiss-Prot
    Q6PAP3, Q6ZPQ9, Q9D2D7
    Related
    ENSMUST00000147022.8
    Conserved Domains (5) summary
    PHA03247
    Location:169 → 532
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:30 → 281
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00017
    Location:966 → 986
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:795 → 877
    zf-C2H2_8; C2H2-type zinc ribbon
    pfam16622
    Location:1131 → 1159
    zf-C2H2_11; zinc-finger C2H2-type

  2. NM_030074.3 → NP_084350.1  zinc finger protein 687

    See identical proteins and their annotated locations for NP_084350.1

    Status: VALIDATED

    Source sequence(s)
    AK019851, AK129360
    Consensus CDS
    CCDS17600.1
    UniProtKB/Swiss-Prot
    Q6PAP3, Q6ZPQ9, Q9D2D7
    Related
    ENSMUSP00000019482.2, ENSMUST00000019482.8
    Conserved Domains (5) summary
    PHA03247
    Location:169 → 532
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:30 → 281
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00017
    Location:966 → 986
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:795 → 877
    zf-C2H2_8; C2H2-type zinc ribbon
    pfam16622
    Location:1131 → 1159
    zf-C2H2_11; zinc-finger C2H2-type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    94901726..94923259 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252898.2 → XP_030108758.1  zinc finger protein 687 isoform X1

    UniProtKB/Swiss-Prot
    Q6PAP3, Q6ZPQ9, Q9D2D7
    Conserved Domains (5) summary
    PHA03247
    Location:169 → 532
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:30 → 281
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00017
    Location:966 → 986
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:795 → 877
    zf-C2H2_8; C2H2-type zinc ribbon
    pfam16622
    Location:1131 → 1159
    zf-C2H2_11; zinc-finger C2H2-type

  2. XM_036163410.1 → XP_036019303.1  zinc finger protein 687 isoform X1

    UniProtKB/Swiss-Prot
    Q6PAP3, Q6ZPQ9, Q9D2D7
    Conserved Domains (5) summary
    PHA03247
    Location:169 → 532
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:30 → 281
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00017
    Location:966 → 986
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:795 → 877
    zf-C2H2_8; C2H2-type zinc ribbon
    pfam16622
    Location:1131 → 1159
    zf-C2H2_11; zinc-finger C2H2-type

  3. XM_036163408.1 → XP_036019301.1  zinc finger protein 687 isoform X1

    UniProtKB/Swiss-Prot
    Q6PAP3, Q6ZPQ9, Q9D2D7
    Conserved Domains (5) summary
    PHA03247
    Location:169 → 532
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:30 → 281
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00017
    Location:966 → 986
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:795 → 877
    zf-C2H2_8; C2H2-type zinc ribbon
    pfam16622
    Location:1131 → 1159
    zf-C2H2_11; zinc-finger C2H2-type

  4. XM_036163409.1 → XP_036019302.1  zinc finger protein 687 isoform X1

    UniProtKB/Swiss-Prot
    Q6PAP3, Q6ZPQ9, Q9D2D7
    Conserved Domains (5) summary
    PHA03247
    Location:169 → 532
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:30 → 281
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00017
    Location:966 → 986
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:795 → 877
    zf-C2H2_8; C2H2-type zinc ribbon
    pfam16622
    Location:1131 → 1159
    zf-C2H2_11; zinc-finger C2H2-type

  5. XM_030252894.1 → XP_030108754.1  zinc finger protein 687 isoform X1

    UniProtKB/Swiss-Prot
    Q6PAP3, Q6ZPQ9, Q9D2D7
    Conserved Domains (5) summary
    PHA03247
    Location:169 → 532
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:30 → 281
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00017
    Location:966 → 986
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:795 → 877
    zf-C2H2_8; C2H2-type zinc ribbon
    pfam16622
    Location:1131 → 1159
    zf-C2H2_11; zinc-finger C2H2-type

  6. XM_036163407.1 → XP_036019300.1  zinc finger protein 687 isoform X1

    UniProtKB/Swiss-Prot
    Q6PAP3, Q6ZPQ9, Q9D2D7
    Conserved Domains (5) summary
    PHA03247
    Location:169 → 532
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:30 → 281
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00017
    Location:966 → 986
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:795 → 877
    zf-C2H2_8; C2H2-type zinc ribbon
    pfam16622
    Location:1131 → 1159
    zf-C2H2_11; zinc-finger C2H2-type

  7. XM_036163405.1 → XP_036019298.1  zinc finger protein 687 isoform X1

    UniProtKB/Swiss-Prot
    Q6PAP3, Q6ZPQ9, Q9D2D7
    Conserved Domains (5) summary
    PHA03247
    Location:169 → 532
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:30 → 281
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00017
    Location:966 → 986
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:795 → 877
    zf-C2H2_8; C2H2-type zinc ribbon
    pfam16622
    Location:1131 → 1159
    zf-C2H2_11; zinc-finger C2H2-type

  8. XM_036163406.1 → XP_036019299.1  zinc finger protein 687 isoform X1

    UniProtKB/Swiss-Prot
    Q6PAP3, Q6ZPQ9, Q9D2D7
    Conserved Domains (5) summary
    PHA03247
    Location:169 → 532
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:30 → 281
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00017
    Location:966 → 986
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:795 → 877
    zf-C2H2_8; C2H2-type zinc ribbon
    pfam16622
    Location:1131 → 1159
    zf-C2H2_11; zinc-finger C2H2-type

  9. XM_030252893.2 → XP_030108753.1  zinc finger protein 687 isoform X1

    UniProtKB/Swiss-Prot
    Q6PAP3, Q6ZPQ9, Q9D2D7
    Conserved Domains (5) summary
    PHA03247
    Location:169 → 532
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:30 → 281
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00017
    Location:966 → 986
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:795 → 877
    zf-C2H2_8; C2H2-type zinc ribbon
    pfam16622
    Location:1131 → 1159
    zf-C2H2_11; zinc-finger C2H2-type

  10. XM_006502307.4 → XP_006502370.1  zinc finger protein 687 isoform X1

    See identical proteins and their annotated locations for XP_006502370.1

    UniProtKB/Swiss-Prot
    Q6PAP3, Q6ZPQ9, Q9D2D7
    Conserved Domains (5) summary
    PHA03247
    Location:169 → 532
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:30 → 281
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00017
    Location:966 → 986
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:795 → 877
    zf-C2H2_8; C2H2-type zinc ribbon
    pfam16622
    Location:1131 → 1159
    zf-C2H2_11; zinc-finger C2H2-type

  11. XM_030252895.2 → XP_030108755.1  zinc finger protein 687 isoform X1

    UniProtKB/Swiss-Prot
    Q6PAP3, Q6ZPQ9, Q9D2D7
    Conserved Domains (5) summary
    PHA03247
    Location:169 → 532
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:30 → 281
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00017
    Location:966 → 986
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:795 → 877
    zf-C2H2_8; C2H2-type zinc ribbon
    pfam16622
    Location:1131 → 1159
    zf-C2H2_11; zinc-finger C2H2-type
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D2D7.1 GenPept UniProtKB/Swiss-Prot:Q9D2D7

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