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Thyn1 thymocyte nuclear protein 1 [ Mus musculus (house mouse) ]

Gene ID: 77862, updated on 21-Apr-2024

Summary

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Official Symbol
Thyn1provided by MGI
Official Full Name
thymocyte nuclear protein 1provided by MGI
Primary source
MGI:MGI:1925112
See related
Ensembl:ENSMUSG00000035443 AllianceGenome:MGI:1925112
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MY105; Thy28; MDS012; HSPC144; D730042P09Rik
Summary
Located in nucleus. Orthologous to human THYN1 (thymocyte nuclear protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 15.5), CNS E11.5 (RPKM 15.3) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A4; 9 12.06 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (26910950..26918632)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (26999642..27007336)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene zinc finger CCCH type containing 11A pseudogene Neighboring gene acyl-Coenzyme A dehydrogenase family, member 8 Neighboring gene STARR-positive B cell enhancer ABC_E8282 Neighboring gene VPS26 retromer complex component B Neighboring gene STARR-positive B cell enhancer ABC_E8283 Neighboring gene STARR-positive B cell enhancer ABC_E3819 Neighboring gene non-SMC condensin II complex, subunit D3 Neighboring gene STARR-seq mESC enhancer starr_23617 Neighboring gene junction adhesion molecule 3 Neighboring gene STARR-seq mESC enhancer starr_23618 Neighboring gene predicted gene, 57534

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Normal B cell development and Pax5 expression in Thy28/ThyN1-deficient mice. Kitaura F, et al. PLoS One, 2019. PMID 31329649, Free PMC Article
  2. Thy28 protects against anti-CD3-mediated thymic cell death in vivo. Toyota H, et al. Apoptosis, 2015 Apr. PMID 25547913
  3. Thy28 partially prevents apoptosis induction following engagement of membrane immunoglobulin in WEHI-231 B lymphoma cells. Toyota H, et al. Cell Mol Biol Lett, 2012 Mar. PMID 22139584, Free PMC Article
  4. Modulation of mThy28 nuclear protein expression during thymocyte development. Jiang X, et al. Tissue Cell, 2003 Dec. PMID 14580360
  5. Anti-IgM-induced down-regulation of nuclear Thy28 protein expression in Ramos B lymphoma cells. Jiang XZ, et al. Apoptosis, 2003 Oct. PMID 14601557

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Thy28-deficient mice showed normal development of B cells and unaltered Pax5 expression.
    Title: Normal B cell development and Pax5 expression in Thy28/ThyN1-deficient mice.
  2. Modulation of Thy28 expression plays a crucial role in the determination of thymic cell fate.
    Title: Thy28 protects against anti-CD3-mediated thymic cell death in vivo.
  3. Thy28 regulates mIg-mediated apoptotic events through the JNK-H(2)O(2) activation pathway, concomitant with an accumulation of cells in G1 phase associated with upregulation of p27(Kip1)
    Title: Thy28 partially prevents apoptosis induction following engagement of membrane immunoglobulin in WEHI-231 B lymphoma cells.
  4. down-regulation of the nuclear Thy28 expression appears to correlate with the induction of apoptosis in Ramos B lymphoma cells
    Title: Anti-IgM-induced down-regulation of nuclear Thy28 protein expression in Ramos B lymphoma cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
thymocyte nuclear protein 1
Names
mThy28
thymocyte protein thy28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001326361.1 → NP_001313290.1  thymocyte nuclear protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a frame-shifting internal exon, compared to variant 1. This variant encodes a shorter protein (isoform 2) with a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK077639, BE953030, BY253816, DV062524
    Consensus CDS
    CCDS90522.1
    UniProtKB/TrEMBL
    Q8BJZ7
    Related
    ENSMUSP00000151200.2, ENSMUST00000213770.2
    Conserved Domains (1) summary
    cl00728
    Location:56 → 161
    EVE; EVE domain

  2. NM_144543.2 → NP_653126.1  thymocyte nuclear protein 1 isoform 1

    See identical proteins and their annotated locations for NP_653126.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB080370, BE953030, CB236103
    Consensus CDS
    CCDS22937.1
    UniProtKB/Swiss-Prot
    Q91YJ3
    Related
    ENSMUSP00000037614.9, ENSMUST00000039161.10
    Conserved Domains (1) summary
    cl00728
    Location:56 → 225
    EVE; EVE domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    26910950..26918632
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510691.4 → XP_006510754.1  thymocyte nuclear protein 1 isoform X3

  2. XM_006510692.5 → XP_006510755.1  thymocyte nuclear protein 1 isoform X4

  3. XM_006510688.5 → XP_006510751.1  thymocyte nuclear protein 1 isoform X1

    Conserved Domains (1) summary
    cl00728
    Location:79 → 248
    EVE; EVE domain

  4. XM_006510689.5 → XP_006510752.1  thymocyte nuclear protein 1 isoform X2

    Conserved Domains (1) summary
    cl00728
    Location:79 → 184
    EVE; EVE domain

RNA

  1. XR_004935604.1 RNA Sequence

  2. XR_001779072.3 RNA Sequence

  3. XR_003948057.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91YJ3.1 GenPept UniProtKB/Swiss-Prot:Q91YJ3

Gene LinkOut

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