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Stk31 serine threonine kinase 31 [ Mus musculus (house mouse) ]

Gene ID: 77485, updated on 21-Apr-2024

Summary

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Official Symbol
Stk31provided by MGI
Official Full Name
serine threonine kinase 31provided by MGI
Primary source
MGI:MGI:1924735
See related
Ensembl:ENSMUSG00000023403 AllianceGenome:MGI:1924735
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C330007K24Rik
Summary
Enables protein kinase activity. Acts upstream of or within protein phosphorylation. Located in acrosomal vesicle. Is expressed in oocyte. Orthologous to human STK31 (serine/threonine kinase 31). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 3.3) and placenta adult (RPKM 1.7) See more
Orthologs
human all
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Genomic context

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Location:
6 B2.3; 6 23.87 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (49372441..49446440)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (49395506..49469506)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1321 Neighboring gene coiled-coil domain containing 126 Neighboring gene STARR-seq mESC enhancer starr_15828 Neighboring gene STARR-positive B cell enhancer ABC_E3654 Neighboring gene family with sequence similarity 221, member A Neighboring gene STARR-seq mESC enhancer starr_15829 Neighboring gene STARR-seq mESC enhancer starr_15830 Neighboring gene nucleophosmin 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_15831 Neighboring gene STARR-seq mESC enhancer starr_15832 Neighboring gene STARR-seq mESC enhancer starr_15833 Neighboring gene 40S ribosomal protein S6 pseudogene Neighboring gene ribosomal protein L19, pseudogene 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. STK31/TDRD8, a germ cell-specific factor, is dispensable for reproduction in mice. Zhou J, et al. PLoS One, 2014. PMID 24586802, Free PMC Article
  2. Stk31 is dispensable for embryonic development and spermatogenesis in mice. Bao J, et al. Mol Reprod Dev, 2013 Oct. PMID 23929668, Free PMC Article
  3. STK31(TDRD8) is dynamically regulated throughout mouse spermatogenesis and interacts with MIWI protein. Bao J, et al. Histochem Cell Biol, 2012 Mar. PMID 22205278
  4. Accelerated reproductive aging in females lacking a novel centromere protein SYCP2L. Zhou J, et al. Hum Mol Genet, 2015 Nov 15. PMID 26362258, Free PMC Article
  5. An abundance of X-linked genes expressed in spermatogonia. Wang PJ, et al. Nat Genet, 2001 Apr. PMID 11279525

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The function of STK31 may be redundant with other Tdrd proteins in germ cell development.
    Title: STK31/TDRD8, a germ cell-specific factor, is dispensable for reproduction in mice.
  2. Stk31 is dispensable for both embryonic development and spermatogenesis in mice.
    Title: Stk31 is dispensable for embryonic development and spermatogenesis in mice.
  3. STK31 is expressed in embryonic gonocytes of both sexes and postnatal spermatocytes and round spermatids in males. Disruption of the tudor domain and kinase domain of STK31 respectively does not affect fertility in mice. Our data suggest that the function of STK31 may be redundant with other Tdrd proteins in germ cell development.
    Title: STK31/TDRD8, a germ cell-specific factor, is dispensable for reproduction in mice.
  4. Our findings suggest mouse STK31 could be a potential nuage-associated protein in the cytoplasm of mid-to-late spermatocytes and play pivotal roles related to fertilization.
    Title: STK31(TDRD8) is dynamically regulated throughout mouse spermatogenesis and interacts with MIWI protein.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in P granule organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in piRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in P granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase 31
NP_001368889.1
NP_084192.2
XP_006506811.1
XP_030111527.1
XP_030111528.1
XP_030111529.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001381960.1 → NP_001368889.1  serine/threonine-protein kinase 31 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC153385
    UniProtKB/TrEMBL
    E9Q260
    Conserved Domains (3) summary
    COG0419
    Location:274 → 670
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd20430
    Location:38 → 112
    Tudor_TDRD8; Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins
    cl21453
    Location:780 → 899
    PKc_like; Protein Kinases, catalytic domain

  2. NM_029916.2 → NP_084192.2  serine/threonine-protein kinase 31 isoform 1

    See identical proteins and their annotated locations for NP_084192.2

    Status: VALIDATED

    Source sequence(s)
    AC153385
    Consensus CDS
    CCDS39487.1
    UniProtKB/Swiss-Prot
    B2RQM2, E9QLI8, Q99MW1
    UniProtKB/TrEMBL
    E9Q260
    Related
    ENSMUSP00000024171.8, ENSMUST00000024171.14
    Conserved Domains (3) summary
    cd04508
    Location:89 → 129
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:29 → 147
    TUDOR; Tudor domain
    cl21453
    Location:803 → 922
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    49372441..49446440
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255667.2 → XP_030111527.1  serine/threonine-protein kinase 31 isoform X1

    UniProtKB/TrEMBL
    E9Q260
    Conserved Domains (3) summary
    TIGR01612
    Location:231 → 540
    235kDa-fam; reticulocyte binding/rhoptry protein
    pfam00567
    Location:35 → 146
    TUDOR; Tudor domain
    cl21453
    Location:625 → 744
    PKc_like; Protein Kinases, catalytic domain

  2. XM_030255668.2 → XP_030111528.1  serine/threonine-protein kinase 31 isoform X3

    Conserved Domains (3) summary
    TIGR01612
    Location:202 → 448
    235kDa-fam; reticulocyte binding/rhoptry protein
    pfam00567
    Location:35 → 146
    TUDOR; Tudor domain
    cl21453
    Location:533 → 652
    PKc_like; Protein Kinases, catalytic domain

  3. XM_006506748.3 → XP_006506811.1  serine/threonine-protein kinase 31 isoform X2

    See identical proteins and their annotated locations for XP_006506811.1

    UniProtKB/TrEMBL
    E9Q260
    Conserved Domains (3) summary
    COG0419
    Location:274 → 670
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd20430
    Location:38 → 112
    Tudor_TDRD8; Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins
    cl21453
    Location:780 → 899
    PKc_like; Protein Kinases, catalytic domain

  4. XM_030255669.1 → XP_030111529.1  serine/threonine-protein kinase 31 isoform X4

    Conserved Domains (2) summary
    TIGR01612
    Location:64 → 373
    235kDa-fam; reticulocyte binding/rhoptry protein
    cl21453
    Location:458 → 577
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99MW1.2 GenPept UniProtKB/Swiss-Prot:Q99MW1

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