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ZNF155 zinc finger protein 155 [ Homo sapiens (human) ]

Gene ID: 7711, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF155provided by HGNC
Official Full Name
zinc finger protein 155provided by HGNC
Primary source
HGNC:HGNC:12940
See related
Ensembl:ENSG00000204920 MIM:604086; AllianceGenome:HGNC:12940
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
pHZ-96
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 3.4), adrenal (RPKM 2.6) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF155 in Genome Data Viewer
Location:
19q13.31
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (43984188..43998326)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (46807096..46821233)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44488340..44502478)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ZNF45 antisense RNA 1 Neighboring gene zinc finger protein 45 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14746 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14747 Neighboring gene zinc finger protein 221 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10732 Neighboring gene ZNF230 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14748 Neighboring gene zinc finger protein 230 Neighboring gene ZNF222 divergent transcript

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Comparative analysis of a conserved zinc finger gene cluster on human chromosome 19q and mouse chromosome 7. Shannon M, et al. Genomics, 1996 Apr 1. PMID 8617494
  2. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. Tommerup N, et al. Genomics, 1995 May 20. PMID 7557990
  3. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. Shannon M, et al. Genome Res, 2003 Jun. PMID 12743021, Free PMC Article
  4. Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells. Tu LC, et al. Mol Cell Proteomics, 2007 Apr. PMID 17220478
  5. The DNA sequence and biology of human chromosome 19. Grimwood J, et al. Nature, 2004 Apr 1. PMID 15057824

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC161655

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 155
Names
KRAB A domain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001260486.2 → NP_001247415.2  zinc finger protein 155 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (1).
    Source sequence(s)
    AC006213
    Consensus CDS
    CCDS12634.1
    UniProtKB/Swiss-Prot
    A2BDE6, B2RB63, B4DM95, J3KQ08, Q12901, Q6AZZ8, Q9UIE1, Q9UK14
    Related
    ENSP00000481677.1, ENST00000611002.4
    Conserved Domains (3) summary
    smart00349
    Location:8 → 67
    KRAB; krueppel associated box
    COG5048
    Location:202 → 486
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:206 → 226
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001260487.2 → NP_001247416.2  zinc finger protein 155 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (1).
    Source sequence(s)
    AC006213
    Consensus CDS
    CCDS12634.1
    UniProtKB/Swiss-Prot
    A2BDE6, B2RB63, B4DM95, J3KQ08, Q12901, Q6AZZ8, Q9UIE1, Q9UK14
    Conserved Domains (3) summary
    smart00349
    Location:8 → 67
    KRAB; krueppel associated box
    COG5048
    Location:202 → 486
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:206 → 226
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001260488.2 → NP_001247417.2  zinc finger protein 155 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is longer and has a distinct N-terminus, compared to variant 1.
    Source sequence(s)
    AC006213
    Consensus CDS
    CCDS58668.1
    Related
    ENSP00000385163.2, ENST00000407951.6
    Conserved Domains (3) summary
    smart00349
    Location:19 → 78
    KRAB; krueppel associated box
    COG5048
    Location:213 → 497
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:217 → 237
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_003445.4 → NP_003436.4  zinc finger protein 155 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the shorter isoform (1). Variants 1, 2, 3 and 4 encode the same isoform.
    Source sequence(s)
    AC006213
    Consensus CDS
    CCDS12634.1
    UniProtKB/Swiss-Prot
    A2BDE6, B2RB63, B4DM95, J3KQ08, Q12901, Q6AZZ8, Q9UIE1, Q9UK14
    Related
    ENSP00000465691.1, ENST00000590615.5
    Conserved Domains (3) summary
    smart00349
    Location:8 → 67
    KRAB; krueppel associated box
    COG5048
    Location:202 → 486
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:206 → 226
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. NM_198089.3 → NP_932355.3  zinc finger protein 155 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (1).
    Source sequence(s)
    AC006213
    Consensus CDS
    CCDS12634.1
    UniProtKB/Swiss-Prot
    A2BDE6, B2RB63, B4DM95, J3KQ08, Q12901, Q6AZZ8, Q9UIE1, Q9UK14
    Related
    ENSP00000270014.1, ENST00000270014.7
    Conserved Domains (3) summary
    smart00349
    Location:8 → 67
    KRAB; krueppel associated box
    COG5048
    Location:202 → 486
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:206 → 226
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    43984188..43998326
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439370.1 → XP_047295326.1  zinc finger protein 155 isoform X1

  2. XM_024451694.2 → XP_024307462.1  zinc finger protein 155 isoform X1

    Conserved Domains (3) summary
    smart00349
    Location:19 → 78
    KRAB; krueppel associated box
    COG5048
    Location:213 → 497
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:217 → 237
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_047439372.1 → XP_047295328.1  zinc finger protein 155 isoform X1

  4. XM_011527278.4 → XP_011525580.1  zinc finger protein 155 isoform X1

    See identical proteins and their annotated locations for XP_011525580.1

    UniProtKB/Swiss-Prot
    Q12901
    Conserved Domains (3) summary
    smart00349
    Location:19 → 78
    KRAB; krueppel associated box
    COG5048
    Location:213 → 497
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:217 → 237
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_047439373.1 → XP_047295329.1  zinc finger protein 155 isoform X1

  6. XM_047439371.1 → XP_047295327.1  zinc finger protein 155 isoform X2

    UniProtKB/Swiss-Prot
    A2BDE6, B2RB63, B4DM95, J3KQ08, Q12901, Q6AZZ8, Q9UIE1, Q9UK14

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    46807096..46821233
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322019.1 → XP_054177994.1  zinc finger protein 155 isoform X1

  2. XM_054322022.1 → XP_054177997.1  zinc finger protein 155 isoform X1

  3. XM_054322021.1 → XP_054177996.1  zinc finger protein 155 isoform X1

  4. XM_054322018.1 → XP_054177993.1  zinc finger protein 155 isoform X1

  5. XM_054322023.1 → XP_054177998.1  zinc finger protein 155 isoform X1

  6. XM_054322020.1 → XP_054177995.1  zinc finger protein 155 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12901.4 GenPept UniProtKB/Swiss-Prot:Q12901

Gene LinkOut

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