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usp37 ubiquitin specific peptidase 37 [ Danio rerio (zebrafish) ]

Gene ID: 768201, updated on 11-Apr-2024

Summary

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Official Symbol
usp37provided by ZNC
Official Full Name
ubiquitin specific peptidase 37provided by ZNC
Primary source
ZFIN:ZDB-GENE-061013-802
See related
Ensembl:ENSDARG00000040990 AllianceGenome:ZFIN:ZDB-GENE-061013-802
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fi15b04; wu:fi15b04; wu:fi38d03; zgc:152882; zgc:153999
Summary
Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Acts upstream of or within central nervous system morphogenesis and cranial skeletal system development. Predicted to be active in cytosol and nucleus. Orthologous to human USP37 (ubiquitin specific peptidase 37). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 9
Exon count:
24
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (715737..746168, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (716104..746558, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene CASP8 and FADD-like apoptosis regulator Neighboring gene NADH:ubiquinone oxidoreductase subunit B3 Neighboring gene ybeY metalloendoribonuclease Neighboring gene insulin induced gene 2 Neighboring gene uncharacterized LOC101883921

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Waterborne exposure of adult zebrafish to silver nanoparticles and to ionic silver results in differential silver accumulation and effects at cellular and molecular levels. Lacave JM, et al. Sci Total Environ, 2018 Nov 15. PMID 30045502
  2. Importance of deubiquitinases in zebrafish craniofacial development. Tse WKF. Biochem Biophys Res Commun, 2017 Jun 10. PMID 28450118
  3. Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. Tse WK, et al. BMC Genomics, 2009 Dec 30. PMID 20040115, Free PMC Article
  4. Transcriptomic analyses reveal novel genes with sexually dimorphic expression in the zebrafish gonad and brain. Sreenivasan R, et al. PLoS One, 2008 Mar 12. PMID 18335061, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC153999

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type deubiquitinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cysteine-type endopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G1/S transition of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within central nervous system morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cranial skeletal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 37
Names
deubiquitinating enzyme 37
ubiquitin thioesterase 37
ubiquitin thiolesterase 37
ubiquitin-specific-processing protease 37
usp39
NP_001070811.1
XP_009302661.1
XP_017213213.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077343.1 → NP_001070811.1  ubiquitin carboxyl-terminal hydrolase 37

    See identical proteins and their annotated locations for NP_001070811.1

    Status: PROVISIONAL

    Source sequence(s)
    BC124596
    UniProtKB/Swiss-Prot
    A1L1F9, E7F6T8, E7FBK6, F1QUQ3, Q08BR8
    Related
    ENSDARP00000110966.3, ENSDART00000129632.3
    Conserved Domains (3) summary
    cd02257
    Location:323 → 582
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    cd13312
    Location:8 → 111
    PH_USP37_like; Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37
    pfam00443
    Location:323 → 582
    UCH; Ubiquitin carboxyl-terminal hydrolase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    715737..746168 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009304386.3 → XP_009302661.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X2

    UniProtKB/Swiss-Prot
    A1L1F9, E7F6T8, E7FBK6, F1QUQ3, Q08BR8
    UniProtKB/TrEMBL
    A0A8M3AVM6
    Conserved Domains (3) summary
    cd02257
    Location:323 → 582
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    cd13312
    Location:8 → 111
    PH_USP37_like; Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37
    pfam00443
    Location:323 → 582
    UCH; Ubiquitin carboxyl-terminal hydrolase

  2. XM_017357724.2 → XP_017213213.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X1

    UniProtKB/Swiss-Prot
    A1L1F9, E7F6T8, E7FBK6, F1QUQ3, Q08BR8
    UniProtKB/TrEMBL
    A0A8M6Z0Y8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E7F6T8.1 GenPept UniProtKB/Swiss-Prot:E7F6T8

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