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ugt2a5 UDP glucuronosyltransferase 2 family, polypeptide A5 [ Danio rerio (zebrafish) ]

Gene ID: 767705, updated on 27-Mar-2024

Summary

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Official Symbol
ugt2a5provided by ZNC
Official Full Name
UDP glucuronosyltransferase 2 family, polypeptide A5provided by ZNC
Primary source
ZFIN:ZDB-GENE-060929-796
See related
Ensembl:ENSDARG00000011537 AllianceGenome:ZFIN:ZDB-GENE-060929-796
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:153113
Summary
Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in several structures, including eye; gill; heart; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in osteoporosis. Orthologous to several human genes including UGT2A2 (UDP glucuronosyltransferase family 2 member A2); UGT2B11 (UDP glucuronosyltransferase family 2 member B11); and UGT2B15 (UDP glucuronosyltransferase family 2 member B15). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 5
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (69868899..69876203)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (69096347..69103211)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene fibronectin type III and SPRY domain containing 1-like Neighboring gene UDP glucuronosyltransferase 2 family, polypeptide A6 Neighboring gene YTH N6-methyladenosine RNA binding protein C1 Neighboring gene fukutin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Characterization of the zebrafish Ugt repertoire reveals a new class of drug-metabolizing UDP glucuronosyltransferases. Wang Y, et al. Mol Pharmacol, 2014 Jul. PMID 24728488
  2. Cloning and comparative analyses of the zebrafish Ugt repertoire reveal its evolutionary diversity. Huang H, et al. PLoS One, 2010 Feb 10. PMID 20161780, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC153113

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables UDP-glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glucuronosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucuronosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
UDP glucuronosyltransferase 2 family, polypeptide A5
NP_001070111.2
XP_009300318.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001076643.2 → NP_001070111.2  UDP glucuronosyltransferase 2 family, polypeptide A5 precursor

    Status: VALIDATED

    Source sequence(s)
    CU571335
    UniProtKB/TrEMBL
    A0A8M1NB03, B8JMA2
    Related
    ENSDARP00000022219.10, ENSDART00000014649.12
    Conserved Domains (2) summary
    PHA03392
    Location:249 → 485
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    pfam00201
    Location:21 → 519
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    69868899..69876203
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009302043.3 → XP_009300318.1  UDP glucuronosyltransferase 2 family, polypeptide A5 isoform X1

    UniProtKB/TrEMBL
    A0A8M3B035
    Conserved Domains (2) summary
    PHA03392
    Location:7 → 243
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    pfam00201
    Location:3 → 277
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395248.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    159045..165919
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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