abhd12 abhydrolase domain containing 12, lysophospholipase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: abhd12provided by ZNC
Official Full Name: abhydrolase domain containing 12, lysophospholipaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060929-268
See related: Ensembl:ENSDARG00000071004 AllianceGenome:ZFIN:ZDB-GENE-060929-268
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:153367
Summary: Predicted to enable acylglycerol lipase activity; lysophospholipase activity; and palmitoyl-(protein) hydrolase activity. Acts upstream of or within myelination; sensory system development; and swimming behavior. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in gill; gonad; liver; muscle; and nervous system. Used to study PHARC syndrome. Human ortholog(s) of this gene implicated in PHARC syndrome. Orthologous to human ABHD12 (abhydrolase domain containing 12, lysophospholipase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (21158383..21199925, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (21138547..21180089, complement)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables acylglycerol lipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acylglycerol lipase activity	IEA Inferred from Electronic Annotation more info
enables acylglycerol lipase activity	ISS Inferred from Sequence or Structural Similarity more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on ester bonds	IEA Inferred from Electronic Annotation more info
enables lysophospholipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables lysophospholipase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phospholipase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in acylglycerol catabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within anterior lateral line development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within camera-type eye development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in monoacylglycerol catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoacylglycerol catabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within myelination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylserine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylserine catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipid catabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within posterior lateral line neuromast development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retina layer formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within swimming behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lysophosphatidylserine lipase ABHD12

Names: 2-arachidonoylglycerol hydrolase ABHD12; abhydrolase domain-containing protein 12; monoacylglycerol lipase ABHD12; oxidized phosphatidylserine lipase ABHD12

NP_001070065.1

EC 3.1.1.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.