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Qrsl1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 [ Mus musculus (house mouse) ]

Gene ID: 76563, updated on 11-Apr-2024

Summary

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Official Symbol
Qrsl1provided by MGI
Official Full Name
glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1provided by MGI
Primary source
MGI:MGI:1923813
See related
Ensembl:ENSMUSG00000019863 AllianceGenome:MGI:1923813
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GatA; 2700038P16Rik
Summary
Predicted to enable glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity. Acts upstream of or within mitochondrial translation and regulation of protein stability. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 40. Orthologous to human QRSL1 (glutaminyl-tRNA amidotransferase subunit QRSL1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 9.9), CNS E11.5 (RPKM 7.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 B2; 10 23.11 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (43750184..43777742, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (43874188..43901742, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933404K13 gene Neighboring gene STARR-positive B cell enhancer ABC_E10604 Neighboring gene STARR-positive B cell enhancer ABC_E1120 Neighboring gene STARR-seq mESC enhancer starr_26522 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_26525 Neighboring gene STARR-seq mESC enhancer starr_26526 Neighboring gene STARR-seq mESC enhancer starr_26527 Neighboring gene STARR-positive B cell enhancer ABC_E6838 Neighboring gene reticulon 4 interacting protein 1 Neighboring gene STARR-seq mESC enhancer starr_26529 Neighboring gene crystallin beta-gamma domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_26530 Neighboring gene predicted gene, 40636

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Glutamyl-tRNAGln amidotransferase is essential for mammalian mitochondrial translation in vivo. Echevarría L, et al. Biochem J, 2014 May 15. PMID 24579914
  2. Yin Yang 1 Orchestrates a Metabolic Program Required for Both Neural Crest Development and Melanoma Formation. Varum S, et al. Cell Stem Cell, 2019 Apr 4. PMID 30951662
  3. Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner. Zurkirchen L, et al. Nat Commun, 2019 May 16. PMID 31097699, Free PMC Article
  4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity ISO
Inferred from Sequence Orthology
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glutaminyl-tRNAGln biosynthesis via transamidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutaminyl-tRNAGln biosynthesis via transamidation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial translation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mitochondrial translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial translation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of glutamyl-tRNA(Gln) amidotransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of glutamyl-tRNA(Gln) amidotransferase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial
Names
glu-AdT subunit A
glutaminyl-tRNA synthase-like protein 1
glutamyl-tRNA(Gln) amidotransferase subunit A homolog
NP_001074523.1
XP_036011973.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081054.2 → NP_001074523.1  glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

    See identical proteins and their annotated locations for NP_001074523.1

    Status: VALIDATED

    Source sequence(s)
    AK012351
    Consensus CDS
    CCDS35894.1
    UniProtKB/Swiss-Prot
    Q3TDF6, Q6NS53, Q9CZN8
    Related
    ENSMUSP00000020012.7, ENSMUST00000020012.7
    Conserved Domains (2) summary
    PRK00012
    Location:13 → 491
    gatA; aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed
    PRK07488
    Location:5 → 492
    PRK07488; indole acetimide hydrolase; Validated

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    43750184..43777742 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156080.1 → XP_036011973.1  glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial isoform X1

    Conserved Domains (1) summary
    cl18951
    Location:13 → 380
    Amidase

RNA

  1. XR_380090.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CZN8.1 GenPept UniProtKB/Swiss-Prot:Q9CZN8

Gene LinkOut

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