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Aoc1 amine oxidase, copper-containing 1 [ Mus musculus (house mouse) ]

Gene ID: 76507, updated on 21-Apr-2024

Summary

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Official Symbol
Aoc1provided by MGI
Official Full Name
amine oxidase, copper-containing 1provided by MGI
Primary source
MGI:MGI:1923757
See related
Ensembl:ENSMUSG00000029811 AllianceGenome:MGI:1923757
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DAO; Abp1; 1600012D06Rik
Summary
Predicted to enable several functions, including heparin binding activity; metal ion binding activity; and oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor. Predicted to be involved in several processes, including cellular response to azide; cellular response to copper ion starvation; and cellular response to histamine. Predicted to act upstream of or within amiloride transport. Predicted to be located in bicellular tight junction and extracellular exosome. Predicted to be active in plasma membrane. Is expressed in mesonephros and urinary system. Orthologous to human AOC1 (amine oxidase copper containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 196.7), small intestine adult (RPKM 189.0) and 2 other tissues See more
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Genomic context

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Location:
6 B2.3; 6 23.78 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (48872189..48886122)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (48895255..48909188)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 176A Neighboring gene predicted gene 44764 Neighboring gene predicted gene 7932 Neighboring gene STARR-seq mESC enhancer starr_15799 Neighboring gene amine oxidase copper containing 1-like 2 Neighboring gene predicted gene, 24348

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Diamine oxidase knockout mice are not hypersensitive to orally or subcutaneously administered histamine. Karer M, et al. Inflamm Res, 2022 Apr. PMID 35303133, Free PMC Article
  2. Estrogen regulates amiloride-binding protein 1 through CCAAT/enhancer-binding protein-beta in mouse uterus during embryo implantation and decidualization. Liang XH, et al. Endocrinology, 2010 Oct. PMID 20668027
  3. Amine oxidase copper-containing 1 (AOC1) is a downstream target gene of the Wilms tumor protein, WT1, during kidney development. Kirschner KM, et al. J Biol Chem, 2014 Aug 29. PMID 25037221, Free PMC Article
  4. The actin nucleator Cobl is crucial for Purkinje cell development and works in close conjunction with the F-actin binding protein Abp1. Haag N, et al. J Neurosci, 2012 Dec 5. PMID 23223303, Free PMC Article
  5. Src-mediated phosphorylation of mammalian Abp1 (DBNL) regulates podosome rosette formation in transformed fibroblasts. Boateng LR, et al. J Cell Sci, 2012 Mar 1. PMID 22303001, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. findings suggest that WT1-dependent control of polyamine breakdown, which is mediated by changes in AOC1 expression, has a role in kidney organogenesis
    Title: Amine oxidase copper-containing 1 (AOC1) is a downstream target gene of the Wilms tumor protein, WT1, during kidney development.
  2. F-actin-anchored Cobl/Abp1 complexes seem crucial for neuromorphogenesis processes, particularly for the postnatal arborization of Purkinje cells in the cerebellar cortex.
    Title: The actin nucleator Cobl is crucial for Purkinje cell development and works in close conjunction with the F-actin binding protein Abp1.
  3. study identifies a role for the actin binding protein mAbp1 in the formation of podosome rosettes and regulation of invasive cell migration
    Title: Src-mediated phosphorylation of mammalian Abp1 (DBNL) regulates podosome rosette formation in transformed fibroblasts.
  4. Abp1 may be essential for mouse embryo implantation and decidualization.
    Title: Estrogen regulates amiloride-binding protein 1 through CCAAT/enhancer-binding protein-beta in mouse uterus during embryo implantation and decidualization.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables copper ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables copper ion binding ISO
Inferred from Sequence Orthology
more info
  
enables diamine oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables diamine oxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables heparin binding ISO
Inferred from Sequence Orthology
more info
  
enables histamine oxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methylputrescine oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables organic cyclic compound binding ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables primary amine oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables primary amine oxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables propane-1,3-diamine oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables putrescine oxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables quinone binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to copper ion starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in putrescine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to antibiotic IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to antibiotic ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in bicellular tight junction ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
diamine oxidase [copper-containing]; amiloride-sensitive amine oxidase [copper-containing]
Names
ABP
amiloride binding protein 1 (amine oxidase, copper-containing)
amiloride-binding protein 1
amiloride-sensitive amine oxidase
amine oxidase copper domain-containing protein 1
diamine oxidase
histaminase
NP_001155093.1
NP_001155094.1
NP_083914.2
XP_030111522.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161621.1 → NP_001155093.1  diamine oxidase [copper-containing] precursor

    See identical proteins and their annotated locations for NP_001155093.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    AC159547, AK146078
    Consensus CDS
    CCDS51767.1
    UniProtKB/TrEMBL
    E9PYN9, Q3UKB9
    Related
    ENSMUSP00000124085.2, ENSMUST00000162948.7
    Conserved Domains (3) summary
    pfam02727
    Location:44 → 129
    Cu_amine_oxidN2; Copper amine oxidase, N2 domain
    pfam02728
    Location:146 → 245
    Cu_amine_oxidN3; Copper amine oxidase, N3 domain
    pfam01179
    Location:305 → 717
    Cu_amine_oxid; Copper amine oxidase, enzyme domain

  2. NM_001161622.1 → NP_001155094.1  diamine oxidase [copper-containing] precursor

    See identical proteins and their annotated locations for NP_001155094.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant (1). All three variants encode the same protein.
    Source sequence(s)
    AC159547, AK146078, BB868807
    Consensus CDS
    CCDS51767.1
    UniProtKB/TrEMBL
    E9PYN9, Q3UKB9
    Related
    ENSMUSP00000128816.2, ENSMUST00000167529.3
    Conserved Domains (3) summary
    pfam02727
    Location:44 → 129
    Cu_amine_oxidN2; Copper amine oxidase, N2 domain
    pfam02728
    Location:146 → 245
    Cu_amine_oxidN3; Copper amine oxidase, N3 domain
    pfam01179
    Location:305 → 717
    Cu_amine_oxid; Copper amine oxidase, enzyme domain

  3. NM_029638.2 → NP_083914.2  diamine oxidase [copper-containing] precursor

    See identical proteins and their annotated locations for NP_083914.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant (1). All three variants encode the same protein.
    Source sequence(s)
    AC159547, AK146078, BY131896
    Consensus CDS
    CCDS51767.1
    UniProtKB/TrEMBL
    E9PYN9, Q3UKB9
    Related
    ENSMUSP00000031835.8, ENSMUST00000031835.14
    Conserved Domains (3) summary
    pfam02727
    Location:44 → 129
    Cu_amine_oxidN2; Copper amine oxidase, N2 domain
    pfam02728
    Location:146 → 245
    Cu_amine_oxidN3; Copper amine oxidase, N3 domain
    pfam01179
    Location:305 → 717
    Cu_amine_oxid; Copper amine oxidase, enzyme domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    48872189..48886122
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255662.1 → XP_030111522.1  amiloride-sensitive amine oxidase [copper-containing] isoform X1

    UniProtKB/TrEMBL
    E9PYN9, Q3UKB9
    Conserved Domains (3) summary
    pfam02727
    Location:44 → 129
    Cu_amine_oxidN2; Copper amine oxidase, N2 domain
    pfam02728
    Location:146 → 245
    Cu_amine_oxidN3; Copper amine oxidase, N3 domain
    pfam01179
    Location:305 → 717
    Cu_amine_oxid; Copper amine oxidase, enzyme domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8JZQ5.1 GenPept UniProtKB/Swiss-Prot:Q8JZQ5

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