U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Atp11b ATPase, class VI, type 11B [ Mus musculus (house mouse) ]

Gene ID: 76295, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Atp11bprovided by MGI
Official Full Name
ATPase, class VI, type 11Bprovided by MGI
Primary source
MGI:MGI:1923545
See related
Ensembl:ENSMUSG00000037400 AllianceGenome:MGI:1923545
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ATPIF; ATPIR; mKIAA0956; 1110019I14Rik
Summary
Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Predicted to be involved in phospholipid translocation. Predicted to act upstream of or within lipid transport. Predicted to be located in Golgi apparatus; endosome; and membrane. Predicted to be integral component of membrane. Predicted to be active in several cellular components, including endoplasmic reticulum; recycling endosome; and trans-Golgi network. Is expressed in 2-cell stage embryo and 4-cell stage embryo. Orthologous to human ATP11B (ATPase phospholipid transporting 11B (putative)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 18.5), CNS E18 (RPKM 15.8) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
3 17.36 cM; 3 B
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (35808104..35910425)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (35754044..35856276)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene 6639 Neighboring gene STARR-seq mESC enhancer starr_07405 Neighboring gene STARR-seq mESC enhancer starr_07406 Neighboring gene STARR-seq mESC enhancer starr_07409 Neighboring gene STARR-positive B cell enhancer ABC_E9546 Neighboring gene predicted gene, 25696 Neighboring gene STARR-positive B cell enhancer ABC_E7907 Neighboring gene STARR-seq mESC enhancer starr_07413 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene chaperonin containing Tcp1, subunit 8 (theta) pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Reanalysis of ATP11B, a type IV P-type ATPase. Halleck MS, et al. J Biol Chem, 2002 Mar 22. PMID 11790799
  2. Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Miller JA, et al. Development, 2013 Nov. PMID 24154525, Free PMC Article
  3. Deterministic and stochastic allele specific gene expression in single mouse blastomeres. Tang F, et al. PLoS One, 2011. PMID 21731673, Free PMC Article
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (5) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled intramembrane lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
part_of phospholipid-translocating ATPase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
phospholipid-transporting ATPase IF
Names
P4-ATPase flippase complex alpha subunit ATP11B
probable phospholipid-transporting ATPase IF
NP_083846.2
XP_006535637.1
XP_030108731.1
XP_030108733.1
XP_036019283.1
XP_036019284.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029570.4 → NP_083846.2  phospholipid-transporting ATPase IF

    See identical proteins and their annotated locations for NP_083846.2

    Status: VALIDATED

    Source sequence(s)
    BC076603, CF952078, CJ128477, CN535194
    Consensus CDS
    CCDS38414.1
    UniProtKB/Swiss-Prot
    Q6DFW5
    UniProtKB/TrEMBL
    Q6ZQ17
    Related
    ENSMUSP00000029257.9, ENSMUST00000029257.15
    Conserved Domains (1) summary
    cd02073
    Location:41 → 978
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

RNA

  1. NR_151626.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157780, BC076603

  2. NR_151627.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157780, BC076603

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    35808104..35910425
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163391.1 → XP_036019284.1  phospholipid-transporting ATPase IF isoform X4

    Conserved Domains (1) summary
    cl21460
    Location:13 → 590
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  2. XM_036163390.1 → XP_036019283.1  phospholipid-transporting ATPase IF isoform X1

    UniProtKB/TrEMBL
    Q6ZQ17
    Related
    ENSMUSP00000142676.2, ENSMUST00000198599.2
    Conserved Domains (1) summary
    cd02073
    Location:41 → 978
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

  3. XM_006535574.4 → XP_006535637.1  phospholipid-transporting ATPase IF isoform X3

    UniProtKB/TrEMBL
    Q3U2B7
    Related
    ENSMUST00000200445.5
    Conserved Domains (1) summary
    cd02073
    Location:41 → 835
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

  4. XM_030252871.1 → XP_030108731.1  phospholipid-transporting ATPase IF isoform X2

    UniProtKB/TrEMBL
    A0A0G2JE89
    Conserved Domains (2) summary
    cd02073
    Location:1 → 715
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
    cl28910
    Location:654 → 800
    MFS; Major Facilitator Superfamily

  5. XM_030252873.1 → XP_030108733.1  phospholipid-transporting ATPase IF isoform X4

    Conserved Domains (1) summary
    cl21460
    Location:13 → 590
    HAD_like; Haloacid Dehalogenase-like Hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DFW5.1 GenPept UniProtKB/Swiss-Prot:Q6DFW5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous