U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abca6 ATP-binding cassette, sub-family A member 6 [ Mus musculus (house mouse) ]

Gene ID: 76184, updated on 8-Feb-2024

Summary

Go to the top of the page Help
Official Symbol
Abca6provided by MGI
Official Full Name
ATP-binding cassette, sub-family A member 6provided by MGI
Primary source
MGI:MGI:1923434
See related
Ensembl:ENSMUSG00000044749 AllianceGenome:MGI:1923434
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6330565N06Rik
Summary
Predicted to enable ATPase-coupled transmembrane transporter activity and lipid transporter activity. Predicted to be involved in lipid transport. Predicted to be located in Golgi membrane; nucleoplasm; and plasma membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in tail. Orthologous to human ABCA6 (ATP binding cassette subfamily A member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 8.7), liver E18 (RPKM 8.5) and 9 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
11 E1; 11 73.37 cM
Exon count:
41
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (110065464..110142811, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (110174638..110251776, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, sub-family A member 8a Neighboring gene ATP-binding cassette, sub-family A member 9 Neighboring gene STARR-seq mESC enhancer starr_31035 Neighboring gene STARR-positive B cell enhancer ABC_E10728 Neighboring gene STARR-positive B cell enhancer mm9_chr11:110133108-110133408 Neighboring gene STARR-seq mESC enhancer starr_31036 Neighboring gene ATP-binding cassette, sub-family A member 5 Neighboring gene predicted gene, 39445

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Hypercholesterolemia risk associated Abca6 does not regulate lipoprotein metabolism in mice or hamster. He B, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2021 Nov. PMID 34274505
  2. Evolutionary analysis of a cluster of ATP-binding cassette (ABC) genes. Annilo T, et al. Mamm Genome, 2003 Jan. PMID 12532264
  3. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
  4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 
  • Endonuclease-mediated (1)  1 citation

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ATP-binding cassette sub-family A member 6
Names
ATP-binding cassette transporter sub-family A member 6
ATP-binding cassette, sub-family A (ABC1), member 6

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166556.1 → NP_001160028.1  ATP-binding cassette sub-family A member 6 isoform 2

    See identical proteins and their annotated locations for NP_001160028.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to variant 1.
    Source sequence(s)
    AK040652, AK053384
    UniProtKB/Swiss-Prot
    Q8K441
    Related
    ENSMUST00000150988.2
    Conserved Domains (1) summary
    pfam12698
    Location:31 → 376
    ABC2_membrane_3; ABC-2 family transporter protein

  2. NM_001166557.1 → NP_001160029.1  ATP-binding cassette sub-family A member 6 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to variant 1.
    Source sequence(s)
    AK040652, AL603792
    UniProtKB/Swiss-Prot
    Q8K441
    Conserved Domains (1) summary
    pfam12698
    Location:31 → 314
    ABC2_membrane_3; ABC-2 family transporter protein

  3. NM_147218.2 → NP_671751.2  ATP-binding cassette sub-family A member 6 isoform 1

    See identical proteins and their annotated locations for NP_671751.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK040652, AL603792, BC132419
    Consensus CDS
    CCDS25590.1
    UniProtKB/Swiss-Prot
    A2A6R3, Q8BGH0, Q8BPT1, Q8K441
    Related
    ENSMUSP00000035458.8, ENSMUST00000044003.14
    Conserved Domains (1) summary
    TIGR01257
    Location:169 → 1600
    rim_protein; retinal-specific rim ABC transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    110065464..110142811 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534413.3 → XP_006534476.1  ATP-binding cassette sub-family A member 6 isoform X1

    See identical proteins and their annotated locations for XP_006534476.1

    UniProtKB/Swiss-Prot
    A2A6R3, Q8BGH0, Q8BPT1, Q8K441
    Conserved Domains (1) summary
    TIGR01257
    Location:169 → 1600
    rim_protein; retinal-specific rim ABC transporter

  2. XM_006534414.2 → XP_006534477.1  ATP-binding cassette sub-family A member 6 isoform X1

    See identical proteins and their annotated locations for XP_006534477.1

    UniProtKB/Swiss-Prot
    A2A6R3, Q8BGH0, Q8BPT1, Q8K441
    Conserved Domains (1) summary
    TIGR01257
    Location:169 → 1600
    rim_protein; retinal-specific rim ABC transporter

  3. XM_036157058.1 → XP_036012951.1  ATP-binding cassette sub-family A member 6 isoform X2

    Conserved Domains (1) summary
    TIGR01257
    Location:169 → 1499
    rim_protein; retinal-specific rim ABC transporter
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K441.2 GenPept UniProtKB/Swiss-Prot:Q8K441

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous