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Ncapg2 non-SMC condensin II complex, subunit G2 [ Mus musculus (house mouse) ]

Gene ID: 76044, updated on 5-Mar-2024

Summary

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Official Symbol
Ncapg2provided by MGI
Official Full Name
non-SMC condensin II complex, subunit G2provided by MGI
Primary source
MGI:MGI:1923294
See related
Ensembl:ENSMUSG00000042029 AllianceGenome:MGI:1923294
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mtb; Luzp5; CAP-G2; mCAP-G2; 5830426I05Rik
Summary
Enables several functions, including bHLH transcription factor binding activity; histone deacetylase regulator activity; and transmembrane receptor protein tyrosine kinase inhibitor activity. Acts upstream of with a negative effect on transcription by RNA polymerase II. Acts upstream of or within erythrocyte differentiation and inner cell mass cell proliferation. Part of condensin complex. Is active in nucleus. Is expressed in several structures, including axial musculature; brain; hemolymphoid system; liver; and nasal cavity epithelium. Orthologous to human NCAPG2 (non-SMC condensin II complex subunit G2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14 (RPKM 10.5), liver E14.5 (RPKM 8.0) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Ncapg2 in Genome Data Viewer
Location:
12 F2; 12 62.65 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (116368969..116427152)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (116405351..116463532)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene extended synaptotagmin-like protein 2 Neighboring gene RIKEN cDNA 2310058N22 gene Neighboring gene RIKEN cDNA D430020J02 gene Neighboring gene STARR-positive B cell enhancer ABC_E4047 Neighboring gene STARR-seq mESC enhancer starr_33404 Neighboring gene U7 small nuclear RNA, pseudogene 1 Neighboring gene predicted gene, 25112

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. More than blood, a novel gene required for mammalian postimplantation development. Smith ED, et al. Mol Cell Biol, 2004 Feb. PMID 14729962, Free PMC Article
  2. MTB, the murine homolog of condensin II subunit CAP-G2, represses transcription and promotes erythroid cell differentiation. Xu Y, et al. Leukemia, 2006 Jul. PMID 16673016
  3. Overlapping and non-overlapping functions of condensins I and II in neural stem cell divisions. Nishide K, et al. PLoS Genet, 2014 Dec. PMID 25474630, Free PMC Article
  4. Reconstitution and subunit geometry of human condensin complexes. Onn I, et al. EMBO J, 2007 Feb 21. PMID 17268547, Free PMC Article
  5. mRNA expression, splicing and editing in the embryonic and adult mouse cerebral cortex. Dillman AA, et al. Nat Neurosci, 2013 Apr. PMID 23416452, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the condensin II subunit MTB/mCAP-G2 plays a novel function during erythropoiesis
    Title: MTB, the murine homolog of condensin II subunit CAP-G2, represses transcription and promotes erythroid cell differentiation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables bHLH transcription factor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chromosome condensation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_positive_effect erythrocyte differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_positive_effect erythrocyte differentiation TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within inner cell mass cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of chromosome separation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_negative_effect transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of condensin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of condensin complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of condensin complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of condensin complex TAS
Traceable Author Statement
more info
 PubMed 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
condensin-2 complex subunit G2
Names
chromosome-associated protein G2
leucine zipper protein 5
more than blood protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133762.4 → NP_598523.3  condensin-2 complex subunit G2

    See identical proteins and their annotated locations for NP_598523.3

    Status: VALIDATED

    Source sequence(s)
    AC160634, AK081647, AK138871, AK139749, BB700949, BC076631, CK636577
    Consensus CDS
    CCDS26212.1
    UniProtKB/Swiss-Prot
    E9QP71, Q6DFV1, Q6SLL0, Q922D1
    Related
    ENSMUSP00000081889.4, ENSMUST00000084828.5
    Conserved Domains (2) summary
    sd00044
    Location:376 → 404
    HEAT; HEAT repeat [structural motif]
    pfam12422
    Location:213 → 360
    Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    116368969..116427152
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157652.1 → XP_036013545.1  condensin-2 complex subunit G2 isoform X1

    UniProtKB/Swiss-Prot
    E9QP71, Q6DFV1, Q6SLL0, Q922D1
    Conserved Domains (2) summary
    sd00044
    Location:376 → 404
    HEAT; HEAT repeat [structural motif]
    pfam12422
    Location:213 → 360
    Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit

  2. XM_036157653.1 → XP_036013546.1  condensin-2 complex subunit G2 isoform X2

    Conserved Domains (1) summary
    pfam12422
    Location:213 → 360
    Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit

  3. XM_006516356.2 → XP_006516419.1  condensin-2 complex subunit G2 isoform X3

    Conserved Domains (2) summary
    sd00044
    Location:296 → 324
    HEAT; HEAT repeat [structural motif]
    pfam12422
    Location:132 → 280
    Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit

  4. XM_006516350.5 → XP_006516413.1  condensin-2 complex subunit G2 isoform X1

    See identical proteins and their annotated locations for XP_006516413.1

    UniProtKB/Swiss-Prot
    E9QP71, Q6DFV1, Q6SLL0, Q922D1
    Conserved Domains (2) summary
    sd00044
    Location:376 → 404
    HEAT; HEAT repeat [structural motif]
    pfam12422
    Location:213 → 360
    Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit

  5. XM_006516352.5 → XP_006516415.1  condensin-2 complex subunit G2 isoform X1

    See identical proteins and their annotated locations for XP_006516415.1

    UniProtKB/Swiss-Prot
    E9QP71, Q6DFV1, Q6SLL0, Q922D1
    Conserved Domains (2) summary
    sd00044
    Location:376 → 404
    HEAT; HEAT repeat [structural motif]
    pfam12422
    Location:213 → 360
    Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit

  6. XM_006516351.5 → XP_006516414.1  condensin-2 complex subunit G2 isoform X1

    See identical proteins and their annotated locations for XP_006516414.1

    UniProtKB/Swiss-Prot
    E9QP71, Q6DFV1, Q6SLL0, Q922D1
    Conserved Domains (2) summary
    sd00044
    Location:376 → 404
    HEAT; HEAT repeat [structural motif]
    pfam12422
    Location:213 → 360
    Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit

  7. XM_006516354.5 → XP_006516417.1  condensin-2 complex subunit G2 isoform X1

    See identical proteins and their annotated locations for XP_006516417.1

    UniProtKB/Swiss-Prot
    E9QP71, Q6DFV1, Q6SLL0, Q922D1
    Conserved Domains (2) summary
    sd00044
    Location:376 → 404
    HEAT; HEAT repeat [structural motif]
    pfam12422
    Location:213 → 360
    Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit

  8. XM_006516353.4 → XP_006516416.1  condensin-2 complex subunit G2 isoform X1

    See identical proteins and their annotated locations for XP_006516416.1

    UniProtKB/Swiss-Prot
    E9QP71, Q6DFV1, Q6SLL0, Q922D1
    Conserved Domains (2) summary
    sd00044
    Location:376 → 404
    HEAT; HEAT repeat [structural motif]
    pfam12422
    Location:213 → 360
    Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DFV1.2 GenPept UniProtKB/Swiss-Prot:Q6DFV1

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