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Tcam1 testicular cell adhesion molecule 1 [ Mus musculus (house mouse) ]

Gene ID: 75870, updated on 11-Apr-2024

Summary

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Official Symbol
Tcam1provided by MGI
Official Full Name
testicular cell adhesion molecule 1provided by MGI
Primary source
MGI:MGI:1923120
See related
Ensembl:ENSMUSG00000020712 AllianceGenome:MGI:1923120
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930570F09Rik
Summary
Predicted to enable integrin binding activity. Predicted to be involved in cell adhesion. Predicted to act upstream of or within cell-cell adhesion. Predicted to be integral component of plasma membrane. Is expressed in bladder; heart valve; sensory organ; and skeleton. Orthologous to human TCAM1P (testicular cell adhesion molecule 1, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 28.2) See more
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Genomic context

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Location:
11 E1; 11 68.89 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (106163856..106179563)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (106273020..106288737)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene protease (prosome, macropain) 26S subunit, ATPase 5 Neighboring gene predicted gene, 23645 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:106130475-106130662 Neighboring gene STARR-positive B cell enhancer ABC_E598 Neighboring gene STARR-positive B cell enhancer ABC_E3029 Neighboring gene STARR-positive B cell enhancer ABC_E10721 Neighboring gene growth hormone Neighboring gene STARR-seq mESC enhancer starr_30919 Neighboring gene CD79B antigen

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A Testis-Specific Long Non-Coding RNA, lncRNA-Tcam1, Regulates Immune-Related Genes in Mouse Male Germ Cells. Kurihara M, et al. Front Endocrinol (Lausanne), 2017. PMID 29163367, Free PMC Article
  2. A conserved noncoding sequence can function as a spermatocyte-specific enhancer and a bidirectional promoter for a ubiquitously expressed gene and a testis-specific long noncoding RNA. Kurihara M, et al. J Mol Biol, 2014 Aug 26. PMID 25020229
  3. Testicular cell adhesion molecule 1 (TCAM1) is not essential for fertility. Nalam RL, et al. Mol Cell Endocrinol, 2010 Feb 5. PMID 19766163, Free PMC Article
  4. Structure, expression, and conserved physical linkage of mouse testicular cell adhesion molecule-1 (TCAM-1) gene. Sakatani S, et al. Genome, 2000 Dec. PMID 11195349
  5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A conserved noncoding sequence (CNS1) located upstream of TCAM1 is a novel enhancer for Tcam1 gene expression.
    Title: A conserved noncoding sequence can function as a spermatocyte-specific enhancer and a bidirectional promoter for a ubiquitously expressed gene and a testis-specific long noncoding RNA.
  2. Data show that TCAM1 is not essential for male fertility or germ cell function in Mus musculus.
    Title: Testicular cell adhesion molecule 1 (TCAM1) is not essential for fertility.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
testicular cell adhesion molecule 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379686.1 → NP_001366615.1  testicular cell adhesion molecule 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL604045
    UniProtKB/TrEMBL
    Q80X70, Q99NB3
    Conserved Domains (3) summary
    pfam03921
    Location:22 → 107
    ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
    cd00096
    Location:109 → 116
    Ig; Ig strand A [structural motif]
    cl11960
    Location:109 → 209
    Ig; Immunoglobulin domain

  2. NM_029467.3 → NP_083743.2  testicular cell adhesion molecule 1 precursor

    See identical proteins and their annotated locations for NP_083743.2

    Status: VALIDATED

    Source sequence(s)
    AK076581, BC050746
    Consensus CDS
    CCDS48959.1
    UniProtKB/TrEMBL
    Q80X70, Q99NB3
    Related
    ENSMUSP00000044757.4, ENSMUST00000044462.4
    Conserved Domains (3) summary
    pfam03921
    Location:22 → 107
    ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
    cd00096
    Location:109 → 116
    Ig; Ig strand A [structural motif]
    cl11960
    Location:109 → 209
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    106163856..106179563
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534399.5 → XP_006534462.1  testicular cell adhesion molecule 1 isoform X1

    UniProtKB/TrEMBL
    Q80X70
    Conserved Domains (2) summary
    pfam03921
    Location:36 → 125
    ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
    cl11960
    Location:123 → 222
    Ig; Immunoglobulin domain

  2. XM_006534401.5 → XP_006534464.1  testicular cell adhesion molecule 1 isoform X3

    UniProtKB/TrEMBL
    Q80X70
    Conserved Domains (2) summary
    pfam03921
    Location:58 → 147
    ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
    cl11960
    Location:145 → 244
    Ig; Immunoglobulin domain

  3. XM_006534400.5 → XP_006534463.1  testicular cell adhesion molecule 1 isoform X2

    See identical proteins and their annotated locations for XP_006534463.1

    UniProtKB/TrEMBL
    Q80X70, Q99NB3
    Conserved Domains (3) summary
    pfam03921
    Location:22 → 107
    ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
    cd00096
    Location:109 → 116
    Ig; Ig strand A [structural motif]
    cl11960
    Location:109 → 209
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version

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