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Pramex1 PRAME like, X-linked 1 [ Mus musculus (house mouse) ]

Gene ID: 75829, updated on 8-Feb-2024

Summary

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Official Symbol
Pramex1provided by MGI
Official Full Name
PRAME like, X-linked 1provided by MGI
Primary source
MGI:MGI:1923079
See related
Ensembl:ENSMUSG00000031411 AllianceGenome:MGI:1923079
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Prame; 4930534P07Rik
Summary
Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 2.8) See more
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Genomic context

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Location:
X F1; X 57.26 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (134513662..134528437, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (135612954..135627705, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene preferentially expressed antigen in melanoma-like 3 pseudogene Neighboring gene nuclear RNA export factor 7 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene t-complex 11 family, X-linked 2 Neighboring gene STARR-seq mESC enhancer starr_47970 Neighboring gene thymosin beta 15a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deletion of the mouse X-linked Prame gene causes germ cell reduction in spermatogenesis. Lu C, et al. Mol Reprod Dev, 2020 Jun. PMID 32017313
  2. The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling. Epping MT, et al. Cell, 2005 Sep 23. PMID 16179254
  3. A 1.1-Mb segmental deletion on the X chromosome causes meiotic failure in male mice. Zhou J, et al. Biol Reprod, 2013 Jun. PMID 23677977, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deletion of the mouse X-linked Prame gene causes germ cell reduction in spermatogenesis.
    Title: Deletion of the mouse X-linked Prame gene causes germ cell reduction in spermatogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
preferentially expressed antigen in melanoma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029459.3 → NP_083735.3  preferentially expressed antigen in melanoma

    Status: VALIDATED

    Source sequence(s)
    AL671911
    Consensus CDS
    CCDS53190.1
    UniProtKB/TrEMBL
    F7ADI6
    Related
    ENSMUSP00000108784.3, ENSMUST00000113159.9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    134513662..134528437 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318634.3 → XP_017174123.1  preferentially expressed antigen in melanoma isoform X1

    UniProtKB/TrEMBL
    Q9D4Z5
    Conserved Domains (2) summary
    sd00031
    Location:384 → 395
    LRR_1; leucine-rich repeat [structural motif]
    sd00034
    Location:213 → 240
    LRR_AMN1; leucine-rich repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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