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Cdyl2 chromodomain protein, Y chromosome-like 2 [ Mus musculus (house mouse) ]

Gene ID: 75796, updated on 5-Mar-2024

Summary

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Official Symbol
Cdyl2provided by MGI
Official Full Name
chromodomain protein, Y chromosome-like 2provided by MGI
Primary source
MGI:MGI:1923046
See related
Ensembl:ENSMUSG00000031758 AllianceGenome:MGI:1923046
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm20194; 1700029M19Rik; 4930453I21Rik
Summary
Enables methylated histone binding activity. Located in nucleus. Orthologous to human CDYL2 (chromodomain Y like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 1.6), thymus adult (RPKM 1.5) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Cdyl2 in Genome Data Viewer
Location:
8 E1; 8 63.15 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (117295462..117459730, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (116568723..116732991, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr8:119028691-119028992 Neighboring gene STARR-seq mESC enhancer starr_22798 Neighboring gene dynein light chain roadblock-type 2 Neighboring gene predicted gene, 39258 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:119111671-119111780 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:119114162-119114494 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:119114548-119114808 Neighboring gene predicted gene, 31367 Neighboring gene STARR-positive B cell enhancer mm9_chr8:119159393-119159693 Neighboring gene STARR-seq mESC enhancer starr_22801 Neighboring gene STARR-positive B cell enhancer ABC_E8265 Neighboring gene STARR-positive B cell enhancer ABC_E6689 Neighboring gene RIKEN cDNA 4930563M20 gene Neighboring gene translation machinery-associated protein 7 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Specificity of the chromodomain Y chromosome family of chromodomains for lysine-methylated ARK(S/T) motifs. Fischle W, et al. J Biol Chem, 2008 Jul 11. PMID 18450745, Free PMC Article
  2. The CDY-related gene family: coordinated evolution in copy number, expression profile and protein sequence. Dorus S, et al. Hum Mol Genet, 2003 Jul 15. PMID 12837688
  3. Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator. Maier VK, et al. Mol Cell Proteomics, 2015 Jun. PMID 25680957, Free PMC Article
  4. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
  5. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables methylated histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
chromodomain Y-like protein 2
Names
CDY-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029441.3 → NP_083717.1  chromodomain Y-like protein 2

    See identical proteins and their annotated locations for NP_083717.1

    Status: VALIDATED

    Source sequence(s)
    AC112969, BC058956
    Consensus CDS
    CCDS40488.1
    UniProtKB/Swiss-Prot
    Q9D5D8
    UniProtKB/TrEMBL
    Q3UQV4, Q7TQ22
    Related
    ENSMUSP00000104730.3, ENSMUST00000109102.4
    Conserved Domains (2) summary
    cd06558
    Location:249 → 445
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
    cd18634
    Location:6 → 57
    CD_CDY; chromodomain of the Chromodomain Y-like protein family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    117295462..117459730 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312996.3 → XP_017168485.1  chromodomain Y-like protein 2 isoform X1

    UniProtKB/TrEMBL
    Q9CVU3
    Conserved Domains (1) summary
    cd06558
    Location:106 → 302
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D5D8.1 GenPept UniProtKB/Swiss-Prot:Q9D5D8

Gene LinkOut

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