Klf17 Kruppel-like transcription factor 17 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klf17provided by MGI
Official Full Name: Kruppel-like transcription factor 17provided by MGI
Primary source: MGI:MGI:2181068
See related: Ensembl:ENSMUSG00000048626 AllianceGenome:MGI:2181068
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gzf; Zfp393; D4Ertd561e; 7420700M05Rik
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within gamete generation. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; gonad; and lower urinary tract. Orthologous to human KLF17 (Kruppel like factor 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward testis adult (RPKM 10.0) See more
Orthologs: human all
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Genomic context

Location:: 4 D1; 4 53.46 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (117613856..117622863, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (117756659..117765666, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Maternal KLF17 controls zygotic genome activation by acting as a messenger for RNA Pol II recruitment in mouse embryos.
Title: Maternal KLF17 controls zygotic genome activation by acting as a messenger for RNA Pol II recruitment in mouse embryos.
KLF17 promotes human naive pluripotency through repressing MAPK3 and ZIC2.
Title: KLF17 promotes human naive pluripotency through repressing MAPK3 and ZIC2.
Kruppel-like factor 17 upregulates uterine corin expression and promotes spiral artery remodeling in pregnancy.
Title: Krüppel-like factor 17 upregulates uterine corin expression and promotes spiral artery remodeling in pregnancy.
demonstrate that KLF17 expression is significantly downregulated in primary human breast cancer samples and that the combined expression pattern of KLF17 and Id1 can serve as a potential biomarker for lymph node metastasis in breast cancer
Title: KLF17 is a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer.
ZFP393 functions as a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development
Title: Identification of Zfp393, a germ cell-specific gene encoding a novel zinc finger protein.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

General gene information

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Markers

Klf17 (e-PCR), detects polymorphism
- UniSTS:536587

Klf17 (e-PCR), detects polymorphism
- UniSTS:536588

RH127133 (e-PCR)
- UniSTS:207665

RH125559 (e-PCR)
- UniSTS:162373

AU043468 (e-PCR)
- UniSTS:179051

D4Ertd561e (e-PCR), detects polymorphism
- UniSTS:167400

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within gamete generation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Krueppel-like factor 17

Names: Kruppel-like factor 17; germ cell specific zinc finger protein; zinc finger protein 393

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029416.2 → NP_083692.2 Krueppel-like factor 17

See identical proteins and their annotated locations for NP_083692.2

Status: VALIDATED

Source sequence(s)

AK139827, CJ074269, CJ205589

Consensus CDS

CCDS18537.1

UniProtKB/Swiss-Prot

B1ASI5, Q3UT30, Q6P233, Q8CFA7, Q9D351

Related

ENSMUSP00000052316.6, ENSMUST00000062747.6

Conserved Domains (4) summary

COG5048
Location:22 → 317

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:261 → 280

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:316 → 338

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:302 → 325

zf-H2C2_2; Zinc-finger double domain