Dusp9 dual specificity phosphatase 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dusp9provided by MGI
Official Full Name: dual specificity phosphatase 9provided by MGI
Primary source: MGI:MGI:2387107
See related: Ensembl:ENSMUSG00000031383 AllianceGenome:MGI:2387107
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mpk4; Pyst3
Summary: Enables MAP kinase tyrosine/serine/threonine phosphatase activity. Acts upstream of or within negative regulation of MAPK cascade. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and sensory organ. Orthologous to human DUSP9 (dual specificity phosphatase 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in placenta adult (RPKM 192.2), liver E14.5 (RPKM 17.2) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: X A7.3; X 37.37 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (72682995..72687120)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (73639389..73643514)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DUSP9 alleviates hepatic ischemia/reperfusion injury by restraining both mitogen-activated protein kinase and IKK in an apoptosis signal-regulating kinase 1-dependent manner.
Title: DUSP9 alleviates hepatic ischemia/reperfusion injury by restraining both mitogen-activated protein kinase and IKK in an apoptosis signal-regulating kinase 1-dependent manner.
miR-132-3p Modulates DUSP9-Dependent p38/JNK Signaling Pathways to Enhance Inflammation in the Amnion Leading to Labor.
Title: miR-132-3p Modulates DUSP9-Dependent p38/JNK Signaling Pathways to Enhance Inflammation in the Amnion Leading to Labor.
Data demonstrate the epigenetic similarity of sex-matched ESCs and EGCs and identify DUSP9 as a regulator of female-specific hypomethylation.
Title: DUSP9 Modulates DNA Hypomethylation in Female Mouse Pluripotent Stem Cells.
we have identified in this study the MAPK phosphatase Dusp9 as selectively expressed in mouse pDCs.
Title: Selective Expression of the MAPK Phosphatase Dusp9/MKP-4 in Mouse Plasmacytoid Dendritic Cells and Regulation of IFN-β Production.
these findings identify DUSP9 as a critical mediator of BMP signaling to control appropriate ERK activity critical for ESC fate determination.
Title: BMP4 Signaling Acts via dual-specificity phosphatase 9 to control ERK activity in mouse embryonic stem cells.
DUSP9/MKP-4 is a bona fide target of PKA signaling and attenuation of DUSP9/MKP-4 function can mediate cross-talk between the PKA pathway and MAPK signaling through both ERK1/2 and p38alpha in vivo
Title: Phosphorylation of the kinase interaction motif in mitogen-activated protein (MAP) kinase phosphatase-4 mediates cross-talk between protein kinase A and MAP kinase signaling pathways.
Data show that Dusp9 transcripts is expressed in partially overlapping patterns that correspond to regions of active FGF signaling, suggesting combinatorial roles in negative regulation of this pathway during ear development.
Title: Expression of ERK signaling inhibitors Dusp6, Dusp7, and Dusp9 during mouse ear development.
Dusp9 has a protective effect against the development of insulin resistance through its ability to dephosphorylate and inactivate crucial mediators of stress-induced insulin resistance, such as ERK and JNK
Title: Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance.
microtubule disruption by MKP4 provides a novel mechanism for tumor suppression by a cytosolic MKP
Title: Microtubule disruption and tumor suppression by mitogen-activated protein kinase phosphatase 4.
DUSP9/MKP-4 is essential for placental organogenesis but is otherwise dispensable for mammalian embryonic development.
Title: The dual-specificity protein phosphatase DUSP9/MKP-4 is essential for placental function but is not required for normal embryonic development.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dusp9 (e-PCR), detects polymorphism
- UniSTS:516439

Dusp9 (e-PCR), detects polymorphism
- UniSTS:506868

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables MAP kinase tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP kinase tyrosine/serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP kinase tyrosine/serine/threonine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-tyrosine dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dual specificity protein phosphatase 9

Names: dual-specificity MAP kinase phosphatase 4

NP_083628.3

EC 3.1.3.16

EC 3.1.3.48

XP_006528394.1

EC 3.1.3.16

EC 3.1.3.48

XP_006528396.1

EC 3.1.3.16

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029352.3 → NP_083628.3 dual specificity protein phosphatase 9

See identical proteins and their annotated locations for NP_083628.3

Status: PROVISIONAL

Source sequence(s)

AY316312

Consensus CDS

CCDS30206.1

UniProtKB/TrEMBL

Q7TNL7, Q8K1S9

Related

ENSMUSP00000019701.9, ENSMUST00000019701.9

Conserved Domains (3) summary

COG2453
Location:251 → 410

CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]

cd00127
Location:272 → 409

DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

cl00125
Location:5 → 206

RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

72682995..72687120

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006528333.1 → XP_006528396.1 dual specificity protein phosphatase 9 isoform X2

See identical proteins and their annotated locations for XP_006528396.1

UniProtKB/TrEMBL

Q8K1S9

Conserved Domains (2) summary

cd01446
Location:5 → 190

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

cd14566
Location:256 → 392

DSP_MKP_classII; dual specificity phosphatase domain of class II mitogen-activated protein kinase phosphatase
XM_006528331.1 → XP_006528394.1 dual specificity protein phosphatase 9 isoform X1

UniProtKB/TrEMBL

Q8K1S9

Conserved Domains (2) summary

cd14566
Location:260 → 396

DSP_MKP_classII; dual specificity phosphatase domain of class II mitogen-activated protein kinase phosphatase

cl00125
Location:5 → 194

RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...