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Spp2 secreted phosphoprotein 2 [ Mus musculus (house mouse) ]

Gene ID: 75396, updated on 5-Mar-2024

Summary

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Official Symbol
Spp2provided by MGI
Official Full Name
secreted phosphoprotein 2provided by MGI
Primary source
MGI:MGI:1922646
See related
Ensembl:ENSMUSG00000026295 AllianceGenome:MGI:1922646
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
pp-24; spp24; 0610038O04Rik
Summary
Predicted to be involved in protein-containing complex assembly. Predicted to be located in extracellular region. Predicted to be part of protein-containing complex. Is expressed in embryo endoderm; liver lobe; urinary system; and yolk sac. Orthologous to human SPP2 (secreted phosphoprotein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 478.7), kidney adult (RPKM 348.4) and 4 other tissues See more
Orthologs
human all
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Genomic context

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See Spp2 in Genome Data Viewer
Location:
1 D; 1 44.63 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (88334688..88356022)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (88406966..88428300)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene maestro heat-like repeat family member 2A Neighboring gene Holliday junction recognition protein Neighboring gene STARR-positive B cell enhancer mm9_chr1:90185502-90185802 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90186563-90186863 Neighboring gene STARR-positive B cell enhancer mm9_chr1:90195708-90196009 Neighboring gene transient receptor potential cation channel, subfamily M, member 8 Neighboring gene STARR-seq mESC enhancer starr_01631 Neighboring gene STARR-seq mESC enhancer starr_01632 Neighboring gene STARR-seq mESC enhancer starr_01633 Neighboring gene predicted gene 29538 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:90371230-90371404 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:90372096-90372342 Neighboring gene predicted gene 28888 Neighboring gene glutamine repeat protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Carboxy terminus of secreted phosphoprotein-24 kDa (spp24) is essential for full inhibition of BMP-2 activity. Brochmann EJ, et al. J Orthop Res, 2010 Sep. PMID 20162696
  2. Characterization of the human secreted phosphoprotein 24 gene (SPP2) and comparison of the protein sequence in nine species. Bennett CS, et al. Matrix Biol, 2004 Feb. PMID 15062857
  3. A systematic screen for genes expressed in definitive endoderm by Serial Analysis of Gene Expression (SAGE). Hou J, et al. BMC Dev Biol, 2007 Aug 2. PMID 17683524, Free PMC Article
  4. Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model. Niborski LL, et al. Dis Model Mech, 2021 May 1. PMID 33737325, Free PMC Article
  5. Inflammation-like changes in the urothelium of Lifr-deficient mice and LIFR-haploinsufficient humans with urinary tract anomalies. Christians A, et al. Hum Mol Genet, 2020 May 8. PMID 32179912

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. proteolytic processing of spp24 affects the interaction of this protein with BMP-2 and this affects the function of the protein
    Title: Carboxy terminus of secreted phosphoprotein-24 kDa (spp24) is essential for full inhibition of BMP-2 activity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in bone remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
secreted phosphoprotein 24
Names
secreted phosphoprotein 2, 24kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029269.3 → NP_083545.1  secreted phosphoprotein 24 precursor

    See identical proteins and their annotated locations for NP_083545.1

    Status: VALIDATED

    Source sequence(s)
    AK002814, BY787973
    Consensus CDS
    CCDS15145.1
    UniProtKB/Swiss-Prot
    Q8K1I3, Q9DCG1
    UniProtKB/TrEMBL
    Q711L0
    Related
    ENSMUSP00000027518.6, ENSMUST00000027518.12
    Conserved Domains (2) summary
    pfam07448
    Location:67 → 203
    Spp-24; Secreted phosphoprotein 24 (Spp-24)
    cl09238
    Location:32 → 100
    CY; Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    88334688..88356022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529918.3 → XP_006529981.1  secreted phosphoprotein 24 isoform X1

    Conserved Domains (2) summary
    cl09238
    Location:32 → 99
    CY; Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.
    cl29764
    Location:67 → 108
    Cathelicidins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K1I3.2 GenPept UniProtKB/Swiss-Prot:Q8K1I3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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