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Slamf7 SLAM family member 7 [ Mus musculus (house mouse) ]

Gene ID: 75345, updated on 3-Apr-2024

Summary

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Official Symbol
Slamf7provided by MGI
Official Full Name
SLAM family member 7provided by MGI
Primary source
MGI:MGI:1922595
See related
Ensembl:ENSMUSG00000038179 AllianceGenome:MGI:1922595
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
19A; CS1; 19A24; CRACC; 4930560D03Rik
Summary
Predicted to enable identical protein binding activity. Acts upstream of or within regulation of natural killer cell activation. Located in external side of plasma membrane. Orthologous to human SLAMF7 (SLAM family member 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 3.6), spleen adult (RPKM 2.3) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Slamf7 in Genome Data Viewer
Location:
1 H3; 1 79.54 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171458506..171480522, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171632403..171653037, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03041 Neighboring gene predicted gene, 35200 Neighboring gene CD244 molecule A Neighboring gene STARR-positive B cell enhancer ABC_E5848 Neighboring gene lymphocyte antigen 9 Neighboring gene STARR-positive B cell enhancer ABC_E5849 Neighboring gene STARR-positive B cell enhancer ABC_E800 Neighboring gene microRNA 7683 Neighboring gene STARR-positive B cell enhancer ABC_E11696 Neighboring gene STARR-positive B cell enhancer ABC_E2586 Neighboring gene CD48 antigen Neighboring gene translational machinery associated 7 homolog (S. cerevisiae), pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SLAMF7 regulates the inflammatory response in macrophages during polymicrobial sepsis. Wu Y, et al. J Clin Invest, 2023 Mar 15. PMID 36749634, Free PMC Article
  2. Signaling Lymphocytic Activation Molecule Family-7 Alleviates Corneal Inflammation by Promoting M2 Polarization. Zhu S, et al. J Infect Dis, 2021 Mar 3. PMID 32702113
  3. CRACC-CRACC interaction between Kupffer and NK cells contributes to poly I:C/D-GalN induced hepatitis. Li Y, et al. PLoS One, 2013. PMID 24098802, Free PMC Article
  4. SLAMF7 modulates B cells and adaptive immunity to regulate susceptibility to CNS autoimmunity. O'Connell P, et al. J Neuroinflammation, 2022 Oct 3. PMID 36199066, Free PMC Article
  5. SLAMF7 and IL-6R define distinct cytotoxic versus helper memory CD8(+) T cells. Loyal L, et al. Nat Commun, 2020 Dec 11. PMID 33311473, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SLAMF7 regulates the inflammatory response in macrophages during polymicrobial sepsis.
    Title: SLAMF7 regulates the inflammatory response in macrophages during polymicrobial sepsis.
  2. SLAMF7 modulates B cells and adaptive immunity to regulate susceptibility to CNS autoimmunity.
    Title: SLAMF7 modulates B cells and adaptive immunity to regulate susceptibility to CNS autoimmunity.
  3. Signaling Lymphocytic Activation Molecule Family-7 Alleviates Corneal Inflammation by Promoting M2 Polarization.
    Title: Signaling Lymphocytic Activation Molecule Family-7 Alleviates Corneal Inflammation by Promoting M2 Polarization.
  4. SLAMF7 Signaling Reprograms T Cells toward Exhaustion in the Tumor Microenvironment.
    Title: SLAMF7 Signaling Reprograms T Cells toward Exhaustion in the Tumor Microenvironment.
  5. SLAMF7 and IL-6R define distinct cytotoxic versus helper memory CD8(+) T cells.
    Title: SLAMF7 and IL-6R define distinct cytotoxic versus helper memory CD8(+) T cells.
  6. phagocytosis of haematopoietic tumour cells during SIRPalpha-CD47 blockade was strictly dependent on SLAM family receptors in vitro and in vivo; in both mouse and human cells, this function required a single SLAM family member, SLAMF7 (also known as CRACC, CS1, CD319), expressed on macrophages and tumour cell targets
    Title: SLAMF7 is critical for phagocytosis of haematopoietic tumour cells via Mac-1 integrin.
  7. CRACC-CRACC interaction between Kupffer and NK cells contributes to poly I:C/D-GalN induced hepatitis.
    Title: CRACC-CRACC interaction between Kupffer and NK cells contributes to poly I:C/D-GalN induced hepatitis.
  8. CRACC was a critical positive regulator of NK cell function mediated by EAT-2.
    Title: Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function.
  9. 2B4, NTB-A and CRACC have roles in the regulation of Natural Killer cell function [review]
    Title: Regulation of NK cell activity by 2B4, NTB-A and CRACC.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of natural killer cell activation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
SLAM family member 7
Names
leukocyte cell-surface antigen
novel Ly9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347184.2 → NP_001334113.1  SLAM family member 7 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC083892, AC091521
    Consensus CDS
    CCDS83636.1
    UniProtKB/TrEMBL
    A0A0A6YW73, A0A0A6YWL9
    Related
    ENSMUSP00000141426.2, ENSMUST00000192024.6
    Conserved Domains (1) summary
    cl11960
    Location:31 → 122
    Ig; Immunoglobulin domain

  2. NM_001412826.1 → NP_001399755.1  SLAM family member 7 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC083892, AC091521
    UniProtKB/TrEMBL
    A0A0R4J2D8
    Related
    ENSMUSP00000106907.4, ENSMUST00000111276.9

  3. NM_144539.6 → NP_653122.2  SLAM family member 7 isoform 1 precursor

    See identical proteins and their annotated locations for NP_653122.2

    Status: VALIDATED

    Source sequence(s)
    AC083892, AC091521
    Consensus CDS
    CCDS15500.1
    UniProtKB/Swiss-Prot
    Q8BHK6, Q8BTL2, Q8CJ63, Q8CJ64, Q8CJ65, Q91XA0
    UniProtKB/TrEMBL
    A0A0R4J2D8
    Related
    ENSMUSP00000141871.2, ENSMUST00000192195.6
    Conserved Domains (1) summary
    cl11960
    Location:31 → 122
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    171458506..171480522 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011238876.4 → XP_011237178.1  SLAM family member 7 isoform X2

    See identical proteins and their annotated locations for XP_011237178.1

    UniProtKB/Swiss-Prot
    Q8BHK6, Q8BTL2, Q8CJ63, Q8CJ64, Q8CJ65, Q91XA0
    UniProtKB/TrEMBL
    A0A0R4J2D8
    Conserved Domains (1) summary
    cl11960
    Location:31 → 122
    Ig; Immunoglobulin domain

  2. XM_030243259.2 → XP_030099119.1  SLAM family member 7 isoform X3

    UniProtKB/TrEMBL
    A0A0A6YW73, A0A0A6YWL9
    Conserved Domains (1) summary
    cl11960
    Location:31 → 122
    Ig; Immunoglobulin domain

  3. XM_036154079.1 → XP_036009972.1  SLAM family member 7 isoform X4

    UniProtKB/TrEMBL
    Q18PI2
    Conserved Domains (2) summary
    cd00096
    Location:16 → 21
    Ig; Ig strand D [structural motif]
    cl11960
    Location:7 → 61
    Ig; Immunoglobulin domain

  4. XM_036154066.1 → XP_036009959.1  SLAM family member 7 isoform X1

    UniProtKB/TrEMBL
    A0A0R4J2D6, Q18PI2
    Related
    ENSMUSP00000141259.2, ENSMUST00000194531.6
    Conserved Domains (2) summary
    cd00096
    Location:27 → 32
    Ig; Ig strand A [structural motif]
    cl11960
    Location:27 → 122
    Ig; Immunoglobulin domain

  5. XM_011238875.4 → XP_011237177.1  SLAM family member 7 isoform X1

    See identical proteins and their annotated locations for XP_011237177.1

    UniProtKB/TrEMBL
    A0A0R4J2D6, Q18PI2
    Conserved Domains (2) summary
    cd00096
    Location:27 → 32
    Ig; Ig strand A [structural motif]
    cl11960
    Location:27 → 122
    Ig; Immunoglobulin domain

  6. XM_011238874.4 → XP_011237176.2  SLAM family member 7 isoform X1

    UniProtKB/TrEMBL
    A0A0R4J2D6, Q18PI2
    Conserved Domains (2) summary
    cd00096
    Location:27 → 32
    Ig; Ig strand A [structural motif]
    cl11960
    Location:27 → 122
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BHK6.2 GenPept UniProtKB/Swiss-Prot:Q8BHK6

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