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aldh1a3 aldehyde dehydrogenase 1 family, member A3 [ Danio rerio (zebrafish) ]

Gene ID: 751785, updated on 27-Mar-2024

Summary

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Official Symbol
aldh1a3provided by ZNC
Official Full Name
aldehyde dehydrogenase 1 family, member A3provided by ZNC
Primary source
ZFIN:ZDB-GENE-061128-2
See related
Ensembl:ENSDARG00000076933 AllianceGenome:ZFIN:ZDB-GENE-061128-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
RALDH3
Summary
Predicted to enable aldehyde dehydrogenase (NAD+) activity. Is expressed in several structures, including brain; immature eye; otic vesicle; pleuroperitoneal region; and sensory system. Human ortholog(s) of this gene implicated in isolated microphthalmia 8. Orthologous to human ALDH1A3 (aldehyde dehydrogenase 1 family member A3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 7
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (9721702..9803108, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (9476538..9557944, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene chondroitin sulfate synthase 1 Neighboring gene leucine-rich repeat kinase 1 Neighboring gene ankyrin repeat and SOCS box containing 7 Neighboring gene lines homolog 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Retinoic Acid Protects and Rescues the Development of Zebrafish Embryonic Retinal Photoreceptor Cells from Exposure to Paclobutrazol. Wang WD, et al. Int J Mol Sci, 2017 Jan 11. PMID 28085063, Free PMC Article
  2. Expressions of Raldh3 and Raldh4 during zebrafish early development. Liang D, et al. Gene Expr Patterns, 2008 Apr. PMID 18262854
  3. A zebrafish model of axenfeld-rieger syndrome reveals that pitx2 regulation by retinoic acid is essential for ocular and craniofacial development. Bohnsack BL, et al. Invest Ophthalmol Vis Sci, 2012 Jan 3. PMID 22125274, Free PMC Article
  4. Is retinoic acid genetic machinery a chordate innovation? Cañestro C, et al. Evol Dev, 2006 Sep-Oct. PMID 16925675
  5. Expression profiles of retinoic acid synthetases ALDH1As and metabolic enzymes CYP26s in adult and embryonic zebrafish (Danio rerio). Xi J, et al. Genet Mol Res, 2015 Apr 27. PMID 25966166

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. mRNA Expression of Raldh3 during zebrafish early development.
    Title: Expressions of Raldh3 and Raldh4 during zebrafish early development.
  2. Expressed in the developing inner ear.
    Title: Expression of zebrafish aldh1a3 (raldh3) and absence of aldh1a1 in teleosts.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables aldehyde dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aldehyde dehydrogenase [NAD(P)+] activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
aldehyde dehydrogenase family 1 member A3
Names
retinaldehyde dehydrogenase family 1 subfamily A3
NP_001038210.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044745.1 → NP_001038210.1  aldehyde dehydrogenase family 1 member A3

    See identical proteins and their annotated locations for NP_001038210.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ300198
    UniProtKB/TrEMBL
    A6XAC4, F6PDD0, Q0H2G3
    Related
    ENSDARP00000055592.5, ENSDART00000055593.8
    Conserved Domains (1) summary
    cd07141
    Location:28 → 506
    ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    9721702..9803108 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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