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bag6l BCL2 associated athanogene 6, like [ Danio rerio (zebrafish) ]

Gene ID: 751663, updated on 11-Apr-2024

Summary

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Official Symbol
bag6lprovided by ZNC
Official Full Name
BCL2 associated athanogene 6, likeprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060307-2
See related
Ensembl:ENSDARG00000077531 AllianceGenome:ZFIN:ZDB-GENE-060307-2
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Bag6; Bat3; bat3l; zgc:153389; si:ch211-215a10.6
Summary
Predicted to enable polyubiquitin modification-dependent protein binding activity; proteasome binding activity; and ribosome binding activity. Predicted to be involved in several processes, including ERAD pathway; animal organ development; and intrinsic apoptotic signaling pathway. Predicted to act upstream of or within apoptotic process and chromatin organization. Predicted to be located in cytosol and nucleus. Predicted to be part of BAT3 complex. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and osteoarthritis. Orthologous to human BAG6 (BAG cochaperone 6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See bag6l in Genome Data Viewer
Location:
chromosome: 19
Exon count:
25
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (30475118..30510952, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (30887500..30923638, complement)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S18B Neighboring gene si:ch211-215a10.4 Neighboring gene ATP-binding cassette, sub-family F (GCN20), member 1 Neighboring gene hippocalcin like 4 Neighboring gene uncharacterized LOC110438138

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evolutionary and Expression Analyses Show Co-option of khdrbs Genes for Origin of Vertebrate Brain. Wang S, et al. Front Genet, 2017. PMID 29354154, Free PMC Article
  2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC153389

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables polyubiquitin modification-dependent protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables proteasome binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ribosome binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in brain development ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum stress-induced pre-emptive quality control ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in kidney development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lung development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteasomal protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in synaptonemal complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tail-anchored membrane protein insertion into ER membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of BAT3 complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
large proline-rich protein BAG6
Names
HLA-B-associated transcript 3, like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001328276.1 → NP_001315205.1  large proline-rich protein BAG6

    Status: VALIDATED

    Source sequence(s)
    BX510301
    UniProtKB/Swiss-Prot
    A3KPW9
    Related
    ENSDARP00000083193.5, ENSDART00000088760.5
    Conserved Domains (3) summary
    cd01809
    Location:7 → 77
    Scythe_N; Ubiquitin-like domain of Scythe protein
    smart00213
    Location:7 → 77
    UBQ; Ubiquitin homologues
    pfam12057
    Location:264 → 382
    DUF3538; Domain of unknown function (DUF3538)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    30475118..30510952 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017352272.2 → XP_017207761.1  large proline-rich protein BAG6 isoform X3

    UniProtKB/TrEMBL
    A0A8M6YTY7
    Related
    ENSDARP00000153568.1, ENSDART00000182974.1

  2. XM_017352271.2 → XP_017207760.1  large proline-rich protein BAG6 isoform X2

    UniProtKB/TrEMBL
    A0A8M6YWF0
    Related
    ENSDARP00000148444.1, ENSDART00000187797.1

  3. XM_017352268.2 → XP_017207757.1  large proline-rich protein BAG6 isoform X1

    UniProtKB/TrEMBL
    A0A8M6YTY2

  4. XM_017352273.2 → XP_017207762.1  large proline-rich protein BAG6 isoform X3

    UniProtKB/TrEMBL
    A0A8M6YTY7

  5. XM_017352270.2 → XP_017207759.1  large proline-rich protein BAG6 isoform X1

    UniProtKB/TrEMBL
    A0A8M6YTY2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001045380.1: Suppressed sequence

    Description
    NM_001045380.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A3KPW9.1 GenPept UniProtKB/Swiss-Prot:A3KPW9

Gene LinkOut

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