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Rprd2 regulation of nuclear pre-mRNA domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 75137, updated on 21-Apr-2024

Summary

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Official Symbol
Rprd2provided by MGI
Official Full Name
regulation of nuclear pre-mRNA domain containing 2provided by MGI
Primary source
MGI:MGI:1922387
See related
Ensembl:ENSMUSG00000028106 AllianceGenome:MGI:1922387
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0460; 2810036A19Rik; 4930535B03Rik; 6720469I21Rik
Summary
Predicted to enable RNA polymerase II complex binding activity. Predicted to be involved in mRNA 3'-end processing. Predicted to be part of RNA polymerase II, holoenzyme. Is expressed in several structures, including blastocyst; early embryo; and extraembryonic component. Orthologous to human RPRD2 (regulation of nuclear pre-mRNA domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 5.3), limb E14.5 (RPKM 5.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 F2.1; 3 41.0 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95667183..95727034, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95759871..95819744, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene microRNA 7014 Neighboring gene extracellular matrix protein 1 Neighboring gene threonyl-tRNA synthetase 2, mitochondrial (putative) Neighboring gene STARR-positive B cell enhancer ABC_E2087 Neighboring gene predicted gene, 26361 Neighboring gene lactate dehydrogenase A pseudogene Neighboring gene STARR-seq mESC enhancer starr_08396 Neighboring gene predicted gene, 29948 Neighboring gene pre-mRNA processing factor 3 Neighboring gene STARR-positive B cell enhancer ABC_E10199 Neighboring gene STARR-positive B cell enhancer ABC_E9562 Neighboring gene mitochondrial ribosomal protein S21

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages. Dietrich JE, et al. EMBO Rep, 2015 Aug. PMID 26142281, Free PMC Article
  2. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II C-terminal domain binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of transcription preinitiation complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
regulation of nuclear pre-mRNA domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081293.2 → NP_001074762.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001074762.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC093317, BC067054
    Consensus CDS
    CCDS38549.1
    UniProtKB/Swiss-Prot
    Q3U3L8, Q6NXI6, Q6ZQA7
    UniProtKB/TrEMBL
    A0A0G2JFW6
    Related
    ENSMUSP00000088297.4, ENSMUST00000090791.8
    Conserved Domains (1) summary
    smart00582
    Location:27 → 145
    RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA

  2. NM_001368178.2 → NP_001355107.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC093317, FQ790371
    UniProtKB/TrEMBL
    A0A0G2JFW6

  3. NM_001368179.1 → NP_001355108.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC093317, FQ790371
    UniProtKB/TrEMBL
    A0A0G2JFW6
    Related
    ENSMUSP00000143333.2, ENSMUST00000200164.5

  4. NM_001368180.1 → NP_001355109.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC093317

  5. NM_001368181.1 → NP_001355110.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC093317

  6. NM_028328.2 → NP_082604.2  regulation of nuclear pre-mRNA domain-containing protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC093317
    Consensus CDS
    CCDS89669.1
    UniProtKB/TrEMBL
    A0A0G2JFN1
    Related
    ENSMUSP00000143240.2, ENSMUST00000197449.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    95667183..95727034 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252863.2 → XP_030108723.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JFW6
    Conserved Domains (3) summary
    PRK03918
    Location:142 → 318
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam05109
    Location:319 → 645
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd17001
    Location:27 → 146
    CID_RPRD2; CID (CTD-Interacting Domain) of Regulation of nuclear pre-mRNA domain-containing protein 2

  2. XM_011240267.4 → XP_011238569.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform X2

    Conserved Domains (2) summary
    pfam05109
    Location:293 → 619
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd17001
    Location:27 → 145
    CID_RPRD2; CID (CTD-Interacting Domain) of Regulation of nuclear pre-mRNA domain-containing protein 2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_029180.1: Suppressed sequence

    Description
    NM_029180.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NXI6.1 GenPept UniProtKB/Swiss-Prot:Q6NXI6

Gene LinkOut

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