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Ppa2 pyrophosphatase (inorganic) 2 [ Mus musculus (house mouse) ]

Gene ID: 74776, updated on 21-Apr-2024

Summary

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Official Symbol
Ppa2provided by MGI
Official Full Name
pyrophosphatase (inorganic) 2provided by MGI
Primary source
MGI:MGI:1922026
See related
Ensembl:ENSMUSG00000028013 AllianceGenome:MGI:1922026
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sid6306; 1110013G13Rik
Summary
Enables protein serine/threonine phosphatase activity. Predicted to be involved in diphosphate metabolic process; phosphate-containing compound metabolic process; and regulation of mitochondrial membrane potential. Located in mitochondrion. Orthologous to human PPA2 (inorganic pyrophosphatase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 80.8), kidney adult (RPKM 69.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 G3; 3 61.71 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (133015842..133083996)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (133310059..133378235)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase, C-terminal domain containing Neighboring gene STARR-positive B cell enhancer mm9_chr3:132754721-132755022 Neighboring gene STARR-positive B cell enhancer ABC_E11218 Neighboring gene integrator complex subunit 12 Neighboring gene Rho guanine nucleotide exchange factor 38 Neighboring gene STARR-seq mESC enhancer starr_09022 Neighboring gene predicted gene, 52616 Neighboring gene STARR-positive B cell enhancer ABC_E10215 Neighboring gene STARR-positive B cell enhancer ABC_E4594 Neighboring gene STARR-positive B cell enhancer ABC_E4595 Neighboring gene STARR-positive B cell enhancer ABC_E9574 Neighboring gene STARR-seq mESC enhancer starr_09023 Neighboring gene STARR-seq mESC enhancer starr_09025 Neighboring gene STARR-seq mESC enhancer starr_09033 Neighboring gene tet methylcytosine dioxygenase 2 Neighboring gene STARR-seq mESC enhancer starr_09034 Neighboring gene STARR-positive B cell enhancer ABC_E6131 Neighboring gene STARR-seq mESC enhancer starr_09035 Neighboring gene predicted gene 49316

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of PINK1 function decreases PP2A activity and promotes autophagy in dopaminergic cells and a murine model. Qi Z, et al. Neurochem Int, 2011 Oct. PMID 21672589
  2. Protein phosphatase subunit G5PR is needed for inhibition of B cell receptor-induced apoptosis. Xing Y, et al. J Exp Med, 2005 Sep 5. PMID 16129705, Free PMC Article
  3. The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes. Rinschen MM, et al. Hum Mol Genet, 2016 Apr 1. PMID 26792178, Free PMC Article
  4. In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics. Distler U, et al. Proteomics, 2014 Nov. PMID 25211037
  5. Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase associates with a protein super-complex integrating multiple metabolic pathways. Narayan SB, et al. PLoS One, 2012. PMID 22496890, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. downregulation of protein phosphatase 2 activity in PINK1-silenced cells promotes the protective effect of autophagy through phosphorylation of Bcl-2
    Title: Loss of PINK1 function decreases PP2A activity and promotes autophagy in dopaminergic cells and a murine model.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC6539

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables inorganic diphosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inorganic diphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in diphosphate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphate-containing compound metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitochondrial membrane potential ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
inorganic pyrophosphatase 2, mitochondrial
Names
PPase 2
pyrophosphate phospho-hydrolase 2
NP_001280570.1
NP_666253.1
XP_006502279.1
XP_006502280.1
XP_030108717.1
XP_030108718.1
XP_036019259.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293641.1 → NP_001280570.1  inorganic pyrophosphatase 2, mitochondrial isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AA444705, AC125040, AK090384
    Consensus CDS
    CCDS80024.1
    UniProtKB/TrEMBL
    D3Z636
    Related
    ENSMUSP00000113369.2, ENSMUST00000122334.8
    Conserved Domains (1) summary
    cl00217
    Location:3 → 284
    pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.

  2. NM_146141.2 → NP_666253.1  inorganic pyrophosphatase 2, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_666253.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA444705, AK090384, AK143475
    Consensus CDS
    CCDS17850.1
    UniProtKB/Swiss-Prot
    Q3UPK3, Q8BTG5, Q91VM9, Q9D1E3
    Related
    ENSMUSP00000029644.10, ENSMUST00000029644.16
    Conserved Domains (1) summary
    cl00217
    Location:3 → 284
    pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    133015842..133083996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163366.1 → XP_036019259.1  inorganic pyrophosphatase 2, mitochondrial isoform X1

  2. XM_006502216.5 → XP_006502279.1  inorganic pyrophosphatase 2, mitochondrial isoform X2

    Conserved Domains (1) summary
    cl00217
    Location:3 → 226
    pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.

  3. XM_030252857.2 → XP_030108717.1  inorganic pyrophosphatase 2, mitochondrial isoform X3

    Conserved Domains (1) summary
    cl00217
    Location:3 → 226
    pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.

  4. XM_006502217.5 → XP_006502280.1  inorganic pyrophosphatase 2, mitochondrial isoform X4

    Conserved Domains (1) summary
    cl00217
    Location:26 → 167
    pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.

  5. XM_030252858.2 → XP_030108718.1  inorganic pyrophosphatase 2, mitochondrial isoform X5

    Conserved Domains (1) summary
    cl00217
    Location:26 → 167
    pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91VM9.1 GenPept UniProtKB/Swiss-Prot:Q91VM9

Gene LinkOut

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